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Open Access 01-04-2008 | Original

Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma

Authors: D. Bosco, A. Belfiore, A. Fava, M. De Rose, M. Plastino, C. Ceccotti, P. Mungari, R. Iannacchero, A. Lavano

Published in: The Journal of Headache and Pain | Issue 2/2008

Abstract

The pathophysiology of pituitary-associated headache is unknown, although structural and functional features of the tumour are proposed mechanisms. The objective of this study was to evaluate whether headache in a population with pituitary micro-adenomas was related to hyperprolactinemia. We recruited 29 patients with microprolactinoma and headache: 16 with migraine (group A) and 13 with tension-type-headache (group B). The prolactin (PRL) levels measured during attacks of headache were significantly higher in nine patients (56%) of group A and in one patient (8%) of group B. In four of the nine patients of group A, PRL increased after thyrotropin-releasing-hormone (TRH) test and induced severe attacks. After dopamine-agonist (DA) treatment, the headache improved in seven (44%) patients of the group A and in two (15%) patients of the group B. Three of the four patients in whom the TRH-test induced headache attacks, improved after DA treatment. We suggest that hyperprolactinemia may contribute to development of pain in migraine subgroups and further TRH-test could be used to predict which patients could benefit by DA therapy.

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Title: Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma
Authors: D. Bosco
A. Belfiore
A. Fava
M. De Rose
M. Plastino
C. Ceccotti
P. Mungari
R. Iannacchero
A. Lavano
Publication date: 01-04-2008
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 2/2008
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-008-0016-z

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Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma

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