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Open Access 01-02-2008 | Original

Performances in cerebellar and neuromuscular transmission tests are correlated in migraine with aura

Authors: Anna Ambrosini, Peter S. Sándor, Victor De Pasqua, Francesco Pierelli, Jean Schoenen

Published in: The Journal of Headache and Pain | Issue 1/2008

Abstract

In previous studies, we described subclinical abnormalities of neuromuscular transmission and cerebellar functions in migraineurs. The aim of this study was to search if these two functions are correlated in the same patient. Thirteen migraineurs [five without aura (MO) and eight with aura (MA)] underwent both stimulation-SFEMG and 3D-movement analysis. Single fiber EMG (SFEMG) results were expressed as the “mean value of consecutive differences” (mean MCD). Precision of arm-reaching movements (measured with an infrared optoelectronic tracking system) was expressed as the average deviation in the horizontal plane. Median values of mean MCD and mean horizontal deviation were not different between MO and MA. However, in MA, but not in MO, both variables were positively correlated. Thus, we conclude that neuromuscular transmission and cerebellar functions are correlated in the same patient when affected by migraine with aura. We suggest that this correlation might be due to a common molecular abnormality.

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Title: Performances in cerebellar and neuromuscular transmission tests are correlated in migraine with aura
Authors: Anna Ambrosini
Peter S. Sándor
Victor De Pasqua
Francesco Pierelli
Jean Schoenen
Publication date: 01-02-2008
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2008
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-008-0004-3

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Performances in cerebellar and neuromuscular transmission tests are correlated in migraine with aura

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