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Techniques in Coloproctology

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01-09-2020 | Colectomy | Technical Note

Resolution of multiply recurrent and multifocal diverticulitis after fecal microbiota transplantation

Authors: D. C. Meyer, S. S. Hill, D. M. Bebinger, J. A. McDade, J. S. Davids, K. Alavi, J. A. Maykel

Published in: Techniques in Coloproctology | Issue 9/2020

Abstract

Background

The exact pathophysiology of diverticulitis is not well understood and may be multifactorial. Recent studies highlight dysbiosis as a plausible mechanism. FMT is a safe strategy to restore commensal colon microbiota and has proven to be an effective treatment for gastrointestinal dysbiosis such as Clostridium difficile infection (CDI). There have been no studies reporting the treatment of diverticulitis with FMT. Our aim was to describe the novel application of fecal microbiota transplantation (FMT) for the treatment of recurrent diverticulitis.

Case

We report a case of a 63-year-old woman who had a 13-year history of multiply recurrent and multifocal diverticulitis previously treated with numerous short courses of intravenous and oral antibiotics for acute flares, two segmental colon resections, and suppressive antibiotic therapy for recurrent disease. Secondary to multiple courses of antibiotics , the patient developed CDI. She was treated with a single round of FMT and subsequently stopped all antibiotics at the time of FMT.

Results

In 20 months of follow-up, the patient has had no further recurrence of diverticulitis or CDI.

Conclusions

FMT could prove to be a novel therapy for refractory diverticulitis but requires further investigation.

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Title: Resolution of multiply recurrent and multifocal diverticulitis after fecal microbiota transplantation
Authors: D. C. Meyer
S. S. Hill
D. M. Bebinger
J. A. McDade
J. S. Davids
K. Alavi
J. A. Maykel
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keywords: Colectomy
Colectomy
Antibiotic
Respiratory Microbiota
Clostridioides Difficile
Diverticulitis
Published in: Techniques in Coloproctology / Issue 9/2020
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI: https://doi.org/10.1007/s10151-020-02275-w

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Resolution of multiply recurrent and multifocal diverticulitis after fecal microbiota transplantation

Abstract

Background

Case

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case

Results

Conclusions

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