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International Journal of Clinical Oncology

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01-04-2018 | Original Article

Neutrophil-to-lymphocyte ratio after pazopanib treatment predicts response in patients with advanced soft-tissue sarcoma

Authors: Hiroshi Kobayashi, Tomotake Okuma, Hiroyuki Oka, Toshihide Hirai, Takahiro Ohki, Masachika Ikegami, Ryoko Sawada, Yusuke Shinoda, Toru Akiyama, Kenji Sato, Satoshi Abe, Hirotaka Kawano, Takahiro Goto, Sakae Tanaka

Published in: International Journal of Clinical Oncology | Issue 2/2018

Abstract

Background

Pazopanib is a multi-tyrosine kinase inhibitor that is used to treat advanced soft-tissue sarcoma, and its efficacy has been confirmed in several clinical trials, although no clinically useful biomarkers have been identified. In other cancers, the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the lymphocyte-to-monocyte ratio (LMR) are associated with chemotherapy response and prognosis. Therefore, we aimed to evaluate the associations of pazopanib response with NLR, PLR, and LMR among patients with advanced soft-tissue sarcoma.

Methods

Data regarding NLR, PLR, and LMR were obtained for 25 patients who received pazopanib for soft-tissue sarcoma. The patients were categorized according to their values for NLR (≥3.8 vs. <3.8), PLR (≥230 vs. <230), and LMR (≥2.4 vs. <2.4), and we evaluated the associations of these markers with progression-free survival and overall survival using Kaplan–Meier curves and Cox proportional models.

Results

No significant differences in progression-free survival or overall survival were observed based on the pre-treatment NLR, PLR, and LMR values. However, decreased NLR values after treatment using pazopanib were independently associated with significantly prolonged progression-free survival (hazard ratio: 0.07, p = 0.001) and overall survival (hazard ratio: 0.17, p = 0.0006).

Conclusions

Decreased NLR values after treatment using pazopanib may predict high efficacy and favorable outcomes among patients with advanced soft-tissue sarcoma.

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Title: Neutrophil-to-lymphocyte ratio after pazopanib treatment predicts response in patients with advanced soft-tissue sarcoma
Authors: Hiroshi Kobayashi
Tomotake Okuma
Hiroyuki Oka
Toshihide Hirai
Takahiro Ohki
Masachika Ikegami
Ryoko Sawada
Yusuke Shinoda
Toru Akiyama
Kenji Sato
Satoshi Abe
Hirotaka Kawano
Takahiro Goto
Sakae Tanaka
Publication date: 01-04-2018
Publisher: Springer Japan
Published in: International Journal of Clinical Oncology / Issue 2/2018
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-017-1199-6

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Abstract

Background

Methods

Results

Conclusions

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