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International Journal of Clinical Oncology

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01-06-2017 | Invited Review Article

Circulating tumor cells: clinical validity and utility

Authors: Luc Cabel, Charlotte Proudhon, Hugo Gortais, Delphine Loirat, Florence Coussy, Jean-Yves Pierga, François-Clément Bidard

Published in: International Journal of Clinical Oncology | Issue 3/2017

Abstract

Circulating tumor cells (CTCs) are rare tumor cells and have been investigated as diagnostic, prognostic and predictive biomarkers in many types of cancer. Although CTCs are not currently used in clinical practice, CTC studies have accumulated a high level of clinical validity, especially in breast, lung, prostate and colorectal cancers. In this review, we present an overview of the current clinical validity of CTCs in metastatic and non-metastatic disease, and the main concepts and studies investigating the clinical utility of CTCs. In particular, this review will focus on breast, lung, colorectal and prostate cancer. Three major topics concerning the clinical utility of CTC are discussed—(1) treatment based on CTCs used as liquid biopsy, (2) treatment based on CTC count or CTC variations, and (3) treatment based on CTC biomarker expression. A summary of published or ongoing phase II and III trials is also presented.

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Title: Circulating tumor cells: clinical validity and utility
Authors: Luc Cabel
Charlotte Proudhon
Hugo Gortais
Delphine Loirat
Florence Coussy
Jean-Yves Pierga
François-Clément Bidard
Publication date: 01-06-2017
Publisher: Springer Japan
Published in: International Journal of Clinical Oncology / Issue 3/2017
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-017-1105-2

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