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International Journal of Clinical Oncology

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Open Access 01-10-2016 | Original Article

Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma

Authors: Noriyuki Hirahara, Takeshi Matsubara, Daisuke Kawahara, Yoko Mizota, Shuichi Ishibashi, Yoshitsugu Tajima

Published in: International Journal of Clinical Oncology | Issue 5/2016

Abstract

Background

It is now widely recognized that outcomes in cancer patients are not determined by their tumor characteristics alone. In this study, we retrospectively analyzed the clinical data of esophageal cancer patients to evaluate the impact of red blood cell distribution width (RDW), platelet distribution width (PDW), and mean platelet volume (MPV) on cancer-specific survival (CSS).

Study design

We retrospectively reviewed a database of 144 consecutive patients who underwent curative esophagectomy for esophageal squamous cell carcinoma at our institute between 2006 and 2014.

Result

In multivariate analysis, pathological stage (pStage) (p = 0.0002) and a high RDW (p = 0.0300) were found to be independently associated with poor survival. Patients with a high RDW had a significantly poorer prognosis in terms of CSS than those with a low RDW (p = 0.004).

Among non-elderly patients, multivariate analysis demonstrated that pStage (p = 0.0120), and a high RDW (p = 0.0092) were independent risk factors for a worse prognosis. In addition, non-elderly patients with a high RDW had a significantly poorer prognosis in terms of CSS than those with a low RDW (p = 0.0003).

On the other hand, univariate analysis demonstrated that pStage (p = 0.0008) was the only significant risk factor for a poor prognosis in elderly patients.

Conclusions

We confirmed that a high RDW was significantly associated with the CSS of esophageal cancer patients after curative esophagectomy. Furthermore, in non-elderly patients, a high RDW was a significant and independent predictor of poor survival.

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Title: Prognostic value of hematological parameters in patients undergoing esophagectomy for esophageal squamous cell carcinoma
Authors: Noriyuki Hirahara
Takeshi Matsubara
Daisuke Kawahara
Yoko Mizota
Shuichi Ishibashi
Yoshitsugu Tajima
Publication date: 01-10-2016
Publisher: Springer Japan
Published in: International Journal of Clinical Oncology / Issue 5/2016
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-016-0986-9

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