Skip to main content
Top
Published in: International Journal of Clinical Oncology 2/2010

01-04-2010 | Case Report

Erythrocytosis caused by erythropoietin-producing thymic carcinoma

Authors: Wataru Munakata, Kazuteru Ohashi, Koji Sakaguchi, Hirotoshi Horio, Tsunekazu Hishima, Hideki Akiyama, Hisashi Sakamaki

Published in: International Journal of Clinical Oncology | Issue 2/2010

Login to get access

Abstract

We describe the first reported case, in an 82-year-old man, of erythrocytosis caused by an erythropoietin (EPO)-producing thymic carcinoma. The patient underwent computed tomography-guided fine-needle aspiration of a 6-cm anterior mediastinal mass, and histological findings revealed thymic squamous cell carcinoma. The existence of EPO was confirmed immunohistochemically using the tumor tissue. Postoperative clinical improvement of erythrocytosis and the decline of EPO suggest a paraneoplastic nature of erythrocytosis as seen in this patient.
Literature
1.
go back to reference Hammond D, Winnick S (1974) Paraneoplastic erythrocytosis and ectopic erythropoietin. Ann N Y Acad Sci 230:219–227CrossRefPubMed Hammond D, Winnick S (1974) Paraneoplastic erythrocytosis and ectopic erythropoietin. Ann N Y Acad Sci 230:219–227CrossRefPubMed
2.
go back to reference Samyn I, Fontaine C, Van Tussenbroek F et al (2004) Paraneoplastic syndromes in cancer: case 1. Polycythemia as a result of ectopic erythropoietin production in metastatic pancreatic carcinoid tumor. J Clin Oncol 22:2240–2242CrossRefPubMed Samyn I, Fontaine C, Van Tussenbroek F et al (2004) Paraneoplastic syndromes in cancer: case 1. Polycythemia as a result of ectopic erythropoietin production in metastatic pancreatic carcinoid tumor. J Clin Oncol 22:2240–2242CrossRefPubMed
3.
go back to reference Marzo F, Lavorgna A, Coluzzi G et al (2008) Erythropoietin in heart and vessels: focus on transcription and signalling pathways. J Thromb Thrombolysis 26:183–187CrossRefPubMed Marzo F, Lavorgna A, Coluzzi G et al (2008) Erythropoietin in heart and vessels: focus on transcription and signalling pathways. J Thromb Thrombolysis 26:183–187CrossRefPubMed
4.
go back to reference Arcasoy MO (2005) Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. Clin Cancer Res 11:20–27PubMed Arcasoy MO (2005) Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. Clin Cancer Res 11:20–27PubMed
5.
go back to reference Newland AM, Black CD (2008) Tumor progression associated with erythropoiesis stimulating agents. Ann Pharmacother 42:1865–1870CrossRefPubMed Newland AM, Black CD (2008) Tumor progression associated with erythropoiesis stimulating agents. Ann Pharmacother 42:1865–1870CrossRefPubMed
6.
go back to reference Noguchi Y, Goto T, Yufu Y et al (1999) Gene expression of erythropoietin in renal cell carcinoma. Intern Med 38:991–994CrossRefPubMed Noguchi Y, Goto T, Yufu Y et al (1999) Gene expression of erythropoietin in renal cell carcinoma. Intern Med 38:991–994CrossRefPubMed
7.
go back to reference Matsuyama M, Yamazaki O, Horii K et al (2000) Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma. J Surg Oncol 75:197–202CrossRefPubMed Matsuyama M, Yamazaki O, Horii K et al (2000) Erythrocytosis caused by an erythropoietin-producing hepatocellular carcinoma. J Surg Oncol 75:197–202CrossRefPubMed
8.
go back to reference Miyoshi I, Saito T, Taguchi H et al (2004) Erythropoietin-producing cerebellar tumour. Br J Haematol 125:105CrossRefPubMed Miyoshi I, Saito T, Taguchi H et al (2004) Erythropoietin-producing cerebellar tumour. Br J Haematol 125:105CrossRefPubMed
9.
go back to reference Yokoyama Y, Shinohara A, Hirokawa M et al (2003) Erythrocytosis due to an erythropoietin-producing large uterine leiomyoma. Gynecol Obstet Invest 56:179–183CrossRefPubMed Yokoyama Y, Shinohara A, Hirokawa M et al (2003) Erythrocytosis due to an erythropoietin-producing large uterine leiomyoma. Gynecol Obstet Invest 56:179–183CrossRefPubMed
10.
go back to reference Bruneval P, Sassy C, Mayeux P et al (1993) Erythropoietin synthesis by tumor cells in a case of meningioma associated with erythrocytosis. Blood 81:1593–1597PubMed Bruneval P, Sassy C, Mayeux P et al (1993) Erythropoietin synthesis by tumor cells in a case of meningioma associated with erythrocytosis. Blood 81:1593–1597PubMed
11.
go back to reference Vogel TW, Brouwers FM, Lubensky IA et al (2005) Differential expression of erythropoietin and its receptor in von Hippel-Lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas. J Clin Endocrinol Metab 90:3747–3751CrossRefPubMed Vogel TW, Brouwers FM, Lubensky IA et al (2005) Differential expression of erythropoietin and its receptor in von Hippel-Lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas. J Clin Endocrinol Metab 90:3747–3751CrossRefPubMed
12.
go back to reference Kawai H, Kojima M, Yokota M et al (2000) Erythropoietin-producing pancreatic ductal adenocarcinoma. Pancreas 21:427–429CrossRefPubMed Kawai H, Kojima M, Yokota M et al (2000) Erythropoietin-producing pancreatic ductal adenocarcinoma. Pancreas 21:427–429CrossRefPubMed
13.
go back to reference Bohnen RF, Banisadre M, Gulbrandson RN et al (1990) Erythrocytosis caused by an erythropoietin-producing breast adenocarcinoma. West J Med 152:417–418PubMed Bohnen RF, Banisadre M, Gulbrandson RN et al (1990) Erythrocytosis caused by an erythropoietin-producing breast adenocarcinoma. West J Med 152:417–418PubMed
14.
go back to reference Miyoshi I, Uemura Y, Nakai T et al (2009) Erythropoietin-producing lung cancer. Intern Med 48:389–390CrossRefPubMed Miyoshi I, Uemura Y, Nakai T et al (2009) Erythropoietin-producing lung cancer. Intern Med 48:389–390CrossRefPubMed
15.
go back to reference Matsuo M, Koga S, Kanetake H et al (2003) EPO-producing gastric carcinoma in a hemodialysis patient. Am J Kidney Dis 42:E3–E4CrossRefPubMed Matsuo M, Koga S, Kanetake H et al (2003) EPO-producing gastric carcinoma in a hemodialysis patient. Am J Kidney Dis 42:E3–E4CrossRefPubMed
16.
go back to reference Wiesener MS, Seyfarth M, Warnecke C et al (2002) Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel–Lindau gene in a renal cell carcinoma. Blood 99:3562–3565CrossRefPubMed Wiesener MS, Seyfarth M, Warnecke C et al (2002) Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel–Lindau gene in a renal cell carcinoma. Blood 99:3562–3565CrossRefPubMed
17.
go back to reference Bunn HF, Gu J, Huang LE et al (1998) Erythropoietin: a model system for studying oxygen-dependent gene regulation. J Exp Biol 201:1197–1201PubMed Bunn HF, Gu J, Huang LE et al (1998) Erythropoietin: a model system for studying oxygen-dependent gene regulation. J Exp Biol 201:1197–1201PubMed
18.
go back to reference Lacombe C, Mayeux P (1998) Biology of erythropoietin. Haematologica 83:724–732PubMed Lacombe C, Mayeux P (1998) Biology of erythropoietin. Haematologica 83:724–732PubMed
Metadata
Title
Erythrocytosis caused by erythropoietin-producing thymic carcinoma
Authors
Wataru Munakata
Kazuteru Ohashi
Koji Sakaguchi
Hirotoshi Horio
Tsunekazu Hishima
Hideki Akiyama
Hisashi Sakamaki
Publication date
01-04-2010
Publisher
Springer Japan
Published in
International Journal of Clinical Oncology / Issue 2/2010
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-010-0029-x

Other articles of this Issue 2/2010

International Journal of Clinical Oncology 2/2010 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine