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01-02-2020 | Review

Impact of echocardiographic wall motion abnormality and cardiac biomarker elevation on outcome after subarachnoid hemorrhage: a meta-analysis

Authors: Limin Zhang, Bing Zhang, Sihua Qi

Published in: Neurosurgical Review | Issue 1/2020

Abstract

Cardiac abnormalities (echocardiographic wall motion abnormality (WMA), biomarker elevation of cardiac troponin (cTn), B-type natriuretic peptide (BNP), or N-terminal prohormone of B-type natriuretic peptide (NT-proBNP)) frequently occur after subarachnoid hemorrhage (SAH). The clinical significance of cardiac abnormalities after SAH remains controversial. This meta-analysis was performed to assess the association between cardiac abnormalities and patient outcomes, including delayed cerebral ischemia (DCI), poor outcome, and death in SAH patients. PubMed and Embase were searched for observational studies reporting an association between cardiac abnormalities and outcome after SAH that were published before 31 December 2017. We extracted data regarding patient characteristics, cardiac abnormalities, and outcome measurements (DCI, poor outcome, or death). Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Twenty-six studies involving 3917 patients were included in our data analysis. WMA showed significant associations with higher rates of DCI (RR, 2.03; 95% CI, 0.99–4.15), poor outcome (RR, 1.45; 95% CI, 1.08–1.93), and death (RR, 2.54; 95% CI, 1.59–4.05). cTn elevation was associated with an increased risk of DCI (RR, 1.48; 95% CI, 1.23–1.79), poor outcome (RR, 1.85; 95% CI, 1.49–2.30), and death (RR, 2.68; 95% CI, 2.19–3.27). Elevation of BNP or NT-proBNT was significantly associated with higher rates of DCI (RR, 1.87; 95% CI, 1.16–3.02). WMA and elevation of cTn, BNP, and NT-proBNP in SAH patients are associated with an increased risk of DCI, poor outcome, and death after SAH.

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Title: Impact of echocardiographic wall motion abnormality and cardiac biomarker elevation on outcome after subarachnoid hemorrhage: a meta-analysis
Authors: Limin Zhang
Bing Zhang
Sihua Qi
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Published in: Neurosurgical Review / Issue 1/2020
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-018-0985-6

At a glance: The STEP trials

Springer Medicine

Impact of echocardiographic wall motion abnormality and cardiac biomarker elevation on outcome after subarachnoid hemorrhage: a meta-analysis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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