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01-10-2018 | Original Article

The role of surgery in intracranial PCNSL

Authors: Guro Jahr, Michele Da Broi, Harald Holte Jr, Klaus Beiske, Torstein R. Meling

Published in: Neurosurgical Review | Issue 4/2018

Abstract

This aimed to evaluate the effect of surgery for overall survival (OS) and progression-free survival (PFS) in intracranial primary CNS lymphoma (PCNSL) of all patients diagnosed at a single center. A prospective database at Oslo University Hospital of PCNSL was reviewed over a 12-year period (2003–2014). Seventy-nine patients with intracranial PCNSL were identified. Deep brain involvement was shown in 63 patients. Thirty-two patients underwent craniotomy with resection, while all other patients had a biopsy. Fifty-seven patients were given chemotherapy: 18 were treated with the MSKCC (Memorial Sloan-Kettering Cancer Center) with rituximab, 21 with the MSKCC without rituximab, and 14 within a Nordic prospective phase II protocol. Forty-four patients achieved complete response (CR) and had OS of 46.3 months. Patients who underwent resection had a median OS of 28.6 versus 11.7 months for those who had a biopsy performed. Resection showed an insignificant prolongation of OS. Multivariate analysis confirmed statistical significance of deep brain involvement only (p < 0.005). Neither chemotherapy regimen, Karnofsky Performance Status (KPS), type of surgery, nor patient age was significant factors for OS or PFS. Resective surgery played no role in significantly improving either OS or PFS and therefore it is not recommended as treatment for PCNSL.

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Title: The role of surgery in intracranial PCNSL
Authors: Guro Jahr
Michele Da Broi
Harald Holte Jr
Klaus Beiske
Torstein R. Meling
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Neurosurgical Review / Issue 4/2018
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-018-0946-0

At a glance: The STEP trials

Springer Medicine

The role of surgery in intracranial PCNSL

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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