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01-04-2009 | Review

The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma

Authors: G. Minniti, V. Esposito, M. Amichetti, R. Maurizi Enrici

Published in: Neurosurgical Review | Issue 2/2009

Abstract

The optimal management of craniopharyngiomas remains controversial. The first-line treatment usually consists of surgical resection. Complete tumor removal provides a high rate of long-term control; however, aggressive surgery is associated with significant incidence of complications. Radiotherapy (RT) is currently used in patients after limited surgery and achieves excellent long-term tumor control. Stereotactic radiotherapy, both in the form of radiosurgery (RS) or fractionated stereotactic radiotherapy (FSRT), has been developed as a more accurate technique of irradiation with more precise tumor localization and consequently a reduction in the volume of normal brain irradiated to high radiation doses. We provide a review of published data on outcome of conventional fractionated RT and modern radiation techniques. FSRT is a suitable treatment technique for all sizes of craniopharyngiomas, and efficacy is comparable to conventional RT. Single-fraction stereotactic radiosurgery is usually delivered to small tumors away from critical structures. Longer follow-up is necessary to confirm the excellent tumor control and the potential reduction of long-term radiation toxicity.

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Title: The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma
Authors: G. Minniti
V. Esposito
M. Amichetti
R. Maurizi Enrici
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: Neurosurgical Review / Issue 2/2009
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-009-0186-4

At a glance: The STEP trials

Springer Medicine

The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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