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Neurosurgical Review
Published in: Neurosurgical Review 2/2003

01-05-2003 | Neurooncology

Migration, proliferation, and invasion of human glioma cells following treatment with simvastatin

Authors: Jan Gliemroth, Henryk Zulewski, Hans Arnold, A. Jorge A. Terzis

Published in: Neurosurgical Review | Issue 2/2003

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Abstract

This study describes the migration, proliferation, and invasion behaviour of two human glioma cell lines, GaMg and U-87 Mg, grown as multicellular tumour spheroids after 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase inhibitor (simvastatin) therapy. Migration and proliferation studies were performed using simvastatin in concentrations of 0.2–30 µg/ml-1. A coculture system in which tumour spheroids were confronted with foetal rat brain aggregates was used for invasion studies. A dose-dependent growth and migratory inhibitory response to simvastatin treatment was observed. Marked invasion of the glioma spheroids into the brain aggregates could be seen in both treated and nontreated groups. Simvastatin therapy inhibits tumour cell growth and migration, but the invasiveness of the remaining tumour cells seems to be unaffected.
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Metadata
Title
Migration, proliferation, and invasion of human glioma cells following treatment with simvastatin
Authors
Jan Gliemroth
Henryk Zulewski
Hans Arnold
A. Jorge A. Terzis
Publication date
01-05-2003
Publisher
Springer-Verlag
Published in
Neurosurgical Review / Issue 2/2003
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-003-0258-9

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