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01-03-2022 | Diode Laser | Review Article

Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials

Authors: Aljaž Golež, Igor Frangež, Ksenija Cankar, Helena Ban Frangež, Maja Ovsenik, Lidija Nemeth

Published in: Lasers in Medical Science | Issue 2/2022

Abstract

Hyposalivation is a condition represented by a reduced salivary flow and may include symptoms such as mouth dryness (xerostomia), loss of taste, pain, dysphagia, and dysphonia, all of which greatly affect an individual’s quality of life.

The aim of the present study was to systematically review the effects of low-level light therapy irradiation (photobiomodulation) on salivary gland function in patients with hyposalivation.

The main question of the systematic review was: “Does low-level light irradiation therapy of the salivary glands affect salivary flow rate or indicators of salivary function (ion and protein concentrations) in patients with xerostomia or hyposalivation?” The question was based on the PICO (participant, intervention, control, outcome) principle and followed the PRISMA guidelines. Databases were explored and papers published between the years 1997 and 2020 were reviewed for the following Mesh-term keywords and their corresponding entry terms in different combinations: “Low-level light therapy,” “Xerostomia,” “Saliva,” “Salivary glands,” “Salivation.”

The initial sample consisted of 220 articles. Of those, 47 articles were used for full-text analysis and 18 were used for a systematic review, 14 were used in meta-analysis. According to their individual quality, most articles were classified as high quality of evidence according to the GRADE score. Meta-analysis of the evidence observed increase of unstimulated salivary flow 0.51 SMD compared to placebo (95% CI: 0.16–0.86), I² = 50%, p = 0.005.

The findings of our review revealed evidence of a beneficial effect of photobiomodulation therapy on salivary gland function. The therapy alleviates xerostomia and hyposalivation. However, these effects are reported short term only and did not induce lasting effects of photobiomodulation therapy on patients’ quality of life.

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Title: Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials
Authors: Aljaž Golež
Igor Frangež
Ksenija Cankar
Helena Ban Frangež
Maja Ovsenik
Lidija Nemeth
Publication date: 01-03-2022
Publisher: Springer London
Keyword: Diode Laser
Published in: Lasers in Medical Science / Issue 2/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03392-0

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Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials

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Evaluating the efficacy of anti-fungal blue light therapies via analyzing tissue section images

Efficacy and safety of pulsed dye laser for the treatment of surgical scars: a systematic review and meta-analysis