Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 2/2022

01-03-2022 | Obesity | Original Article

Effect of extracorporeal shock waves on inflammation and angiogenesis of integumentary tissue in obese individuals: stimulating repair and regeneration

Authors: Débora Aparecida Oliveira Modena, Ciro Dantas Soares, Elaine Cristina Candido, Felipe David Mendonça Chaim, Everton Cazzo, Elinton Adami Chaim

Published in: Lasers in Medical Science | Issue 2/2022

Login to get access

Abstract

The technology of extracorporeal shock wave therapy (ESWT) has been studied around the world for its possible benefits in the treatment and rehabilitation of aesthetic disorders. To better elucidate its real physiological effect on the integumentary tissue, this study was proposed aimed at evaluating whether ESWT can act to stimulate the inflammatory process and angiogenesis in the dermis and epidermis of obese individuals. This is an immunohistological study that evaluated a set of samples of the integumentary tissue of women with grade II obesity with weight loss of 10% of the initial weight undergoing ESWT treatment; the collection of biological material was performed at the time of surgery of bariatric surgery. For immunohistochemical evaluation, the markers to assess the presence and distribution of inflammatory cells, anti-COX-2, CD3, CD20, CD163, and NK were used. For physiological stimulus pathways for blood vessel angiogenesis, markers CD 34, CD 105 and VEGF were used. Fourteen obese women were included in the study. Positivity was evidenced in the epidermal expression of markers of the inflammatory process COX-2, CD3, CD20, NK cells, CD68, and CD163 (p < 0.0001) in the intervention sample when compared to controls. There was a positive expression for the angiogenesis markers CD105 and VEGF (p < 0.0001) when comparing the intervention group with the control group. It was concluded that ESWT can stimulate a local inflammatory process, mediating and modulating important growth factors to act in the repair process and skin tissue regeneration, being considered a promising treatment for skin diseases related to weight gain or loss.
Literature
1.
Dąbrowska AK, Spano F, Derler S et al (2018) The relationship between skin function, barrier properties, and body-dependent factors. Skin Res Technol 24(2):165–174CrossRef
2.
Bonté F, Girard D, Archambault JC, Desmoulière A (2019) Skin changes during ageing. Subcell Biochem 91:249–280CrossRef
3.
Greenway FL (2015) Physiological adaptations to weight loss and factor favoring weight regain. Int J Obes 39(8):1188–1196CrossRef
4.
Chooi YC, Ding C, Magkos F (2019) The epidemiology of obesity. Metab, Clin Exp 92:6–10CrossRef
5.
Modena D, da Silva CN, Grecco C, Guidi RM, Moreira RG, Coelho AA, de Souza JR (2017) Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat Systematic review. J Cosmet Laser Ther 19(6):314–319CrossRef
6.
Knobloch K, Kraemer R (2015) Extracorporeal shock wave therapy (ESWT) for the treatment of cellulite–a current meta-analysis. International journal of surgery (London, England) 24(Pt B):210–217CrossRef
7.
de Lima Morais TM, Meyer PF, de Vasconcellos LS, Silva E, J. C., E Andrade, I. F., de Farias, V., … Soares, C. D. (2019) Effects of the extracorporeal shock wave therapy on the skin: an experimental study. Lasers Med Sci 34(2):389–396CrossRef
8.
Poeggeler B, Schulz C, Pappolla MA et al (2010) Leptin and the skin: a new frontier. Exp Dermatol 19(1):12–18CrossRef
9.
Hirt PA, MD, David E. Castillo, MD, Gil Yosipovitch, MD, and Jonette E. Keri, MD, Ph.D. a, b Miami, Florida. (2019) Skin changes in the obese patient. J Am Acad Dermatol 81(5):1037–1057CrossRef
10.
Malliaropoulos N, Crate G, Meke M, Korakakis V, Nauck T, Lohrer H, et al. (2016) Success and recurrence rate after radial extracorporeal shock wave therapy for plantar fasciopathy: a retrospective study. Biomed Res Int. 1–8.
11.
Kuhn C (2008) Impact of extracorporeal shock waves on the human skin with cellulite: a case study of a unique instance. Clin Interv Aging 3(1):201–210CrossRef
12.
Woodley DT (2017) Distinct fibroblasts in the papillary and reticular dermis: implications for wound healing. Dermatol Clin 35(1):95–100CrossRef
13.
Aguilera-Sáez J, Muñoz P, Serracanta J, Monte A, Barret JP. (2019) Extracorporeal shock wave therapy role in the treatment of burn patients. A systematic literature review. Burns. 3; S0305–4179(19)30211–6.
14.
Gallo JRB, Maschio-Signorini LB, Cabral CRB, de Campos Zuccari DAP, Nogueira ML, Bozola AR, Cury PM, Vidotto A (2019) Skin protein profile after major weight loss and its role in body contouring surgery. Plast Reconstr Surg Glob Open. 19;7(8):e2339
15.
Siems W, Grune T, Voss P, Brenke R (2005) Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite. BioFactors 24(1):275–282CrossRef
16.
Sukubo NG, Tibalt E, Respizzi S, Locati M, d’Agostino MC (2015) Effect of shock waves on macrophages: a possible role in tissue regeneration and remodeling. Int J Surg 24(Pt B):124–130CrossRef
17.
de Girolamo L, Stanco D, Galliera E, Viganò M, Lovati AB, Marazzi MG, Romeo P, Sansone V (2014) Soft-focused extracorporeal shock waves increase the expression of tendon-specific markers and the release of anti-inflammatory cytokines in an adherent culture model of primary human tendon cells. Ultrasound Med Biol 40(6):1204–1215CrossRef
18.
Angehrn F, Kuhn C, Voss, (2007) A Can cellulite be treated with low-energy extracorporeal shock wave therapy? Clin Interv Aging 2(4):623–630PubMedPubMedCentral
19.
de Araújo R, Lôbo M, Trindade K, Silva DF, Pereira N (2019) Fibroblast growth factors: a controlling mechanism of skin aging. Skin Pharmacol Physiol 32(5):275–282CrossRef
20.
Goetz R, Mohammadi M (2013) Explorando mecanismos de sinalização de FGF através das lentes da biologia estrutural. Nat Rev Mol Cell Biol 14(3):166–180CrossRef
21.
Filho D, Medeiros A et al (2007) Efeitos do fator básico de crescimento de fibroblastos e seu antifator na cicatrização e maturação de colágeno da ferida cutânea infectada. Acta Cir Bras 22(1):64–71CrossRef
22.
Humphrey JD, Dufresne ER, Schwartz MA (2014) Mecanotransdução e homeostase da matriz extracelular. Nat Rev Mol Cell Biol 15(12):802–812CrossRef
23.
Alvarez N, Ortiz L, Vicente V, Alcaraz M, Sánchez-Pedreño P (2008) The effects of radiofrequency on skin: experimental study. Lasers Surg Med 40(2):76–82CrossRef
24.
Im C-N, Kim E-H, Park A-K, Park W-Y (2010) Classification of biological effect of 1,763 MHz radiofrequency radiation based on gene expression profiles. Genomics Informatics 8(1):34–40CrossRef
25.
Meyer PF, de Oliveira P, Silva FKBA, da Costa ACS, Pereira CRA, Casenave S, Valentim Silva RM, Araújo-Neto LG, Santos-Filho SD, Aizamaque E, Araújo HG, Bernardo-Filho M, Carvalho MGF, Soares CD (2017) Radiofrequency treatment inducesfibroblast growth factor 2 expression and subsequently promotes neocollagenesisand neoangiogenesis in the skin tissue. Lasers Med Sci 32(8):1727–1736CrossRef
26.
Miller I, Min M, Yang C, Tian C, Gookin S, Carter D, Spencer SL (2018) Ki67 is a graded rather than a binary marker of proliferation versus quiescence. Cell Rep 24(5):1105-1112.e5CrossRef
27.
Modena DAO, Guidi RM, Soares CD, Cazzo E, Chaim EA (2020) Ondas de choque eletromagnéticas na Dermatologia: análise microscopoca de sua interação com a possível resução do tecido adipose. Surg Cosmet Dermatol 04:352–358
28.
Sun X, Kaufman PD (2018) Ki-67: more than a proliferation marker. Chromosoma 127(2):175–186CrossRef
29.
Huang TH, Sun CK, Chen YL et al (2017) A onda de choque aprimora a angiogênese através da ativação e reciclagem do VEGFR2. Mol Med 22:850–862CrossRef
30.
Sundaram S, Sellamuthu K, Nagavelu K, Suma HR, Das A, Narayan R, Chakravortty D, Gopalan J, Eswarappa SM (2018) Stimulation of angiogenesis using single-pulse low-pressure shock wave treatment. J Mol Med (Berl) 96(11):1177–1187CrossRef
31.
Shipman AR, Millington GW (2011) Obesity and the skin. Br J Dermatol 165(4):743–750CrossRef
32.
Wolf AM, Beisiegel U (2007) The effect of loss of excess weight on the metabolic risk factors after bariatric surgery in morbidly and super-obese patients. Obes Surg 17(7):910–919CrossRef
33.
Christ C, Brenke R, Sattler G, Siems W, Novak P, Daser A (2008) Improvement in skin elasticity in the treatment of cellulite and connective tissue weakness by means of extracorporeal pulse activation therapy. Aesthetic Surg J 28(5):538–544CrossRef
34.
Modena DAO, Silva CN, Delinocente TCP, Araújo BT, de Carvalho MT, Grecco C, Moreira GR, Moraes CG, Souza JR, Guidi RM (2019) Shock wave therapy associated with radiofrequency in the treatment of abdominal skin flaccidity. Journal of Dermatology & Cosmetology 3(3):69–73CrossRef
35.
Modena DAO, Nogueira da Silva C, Delinocente TCP, Bianca de Araújo T, de Carvalho TM, Grecco C, Moreira RG, Campos G, de Souza JR, Michelini Guidi R. (2019) Effectiveness of the electromagnetic shock wave therapy in the treatment of cellulite. Dermatol Res Pract 20
36.
Ornitz DM, Itoh N (2015) A via de sinalização do Fator de Crescimento de Fibroblastos. Wiley Interdiscip Rev Dev Biol 4(3):215–266CrossRef
Metadata
Title
Effect of extracorporeal shock waves on inflammation and angiogenesis of integumentary tissue in obese individuals: stimulating repair and regeneration
Authors
Débora Aparecida Oliveira Modena
Ciro Dantas Soares
Elaine Cristina Candido
Felipe David Mendonça Chaim
Everton Cazzo
Elinton Adami Chaim
Publication date
01-03-2022
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 2/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-021-03387-x

Other articles of this Issue 2/2022

Lasers in Medical Science 2/2022 Go to the issue

Original Article

Effects of photobiomodulation on bone remodeling in an osteoblast–osteoclast co-culture system

Original Article

Improvement of apical papilla cell attachment after erbium, chromium-doped yttrium, scandium, gallium, and garnet laser application: a study in an ex vivo immature tooth model

Original Article

Intraoperative detection of human meningioma using a handheld visible resonance Raman analyzer

Original Article

Evaluation of lipolysis and toxicological parameters of low-level laser therapy at different wavelengths and doses in the abdominal subcutaneous tissue

Review Article

Photobiomodulation impacts the levels of inflammatory mediators during orthodontic tooth movement? A systematic review with meta-analysis

Original Article

Comparison of cumulative dispersed energy between conventional phacoemulsification and femtosecond laser-assisted cataract surgery with two different lens fragmentation patterns