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01-03-2022 | Retinal Detachment | Original Article

Photocoagulation-associated spontaneous release of epiretinal membrane secondary to retinal vascular tumor: case series of 8 cases

Authors: Xinyi Ding, Jingli Guo, Gezhi Xu, Wei Liu

Published in: Lasers in Medical Science | Issue 2/2022

Abstract

To evaluate the secondary epiretinal membrane (ERM) response after photocoagulation in retinal vascular tumor. This retrospective interventional case series included 8 patients (8 eyes) who were diagnosed with retinal vascular tumor and secondary ERM. All eyes were treated with photocoagulation and underwent comprehensive ophthalmologic examinations at baseline and at each follow-up. Of the 8 eyes with retinal vascular tumor and associated ERM, 4 eyes (50%) were von Hippel and 4 eyes (50%) were vasoproliferative tumor of the retina. The mean follow-up time was 12.63 ± 14.64 (range, 4–51) months. The BCVA in the eyes at baseline was 1.16 ± 1.10 logMAR (range, HM to 20/40). ERM located in the macular region in 100% of the eyes and led to CME with a mean central foveal thickness of 497.6 ± 147.7 μm (range, 294–736 μm) at presentation. After photocoagulation, the ERM spontaneously peeled in 7 of 8 eyes (87.5%), among which one case required surgical treatment due to complicating tractional retinal detachment. After ERM peeling without complications, 6 eyes recovered normal macular structure, with an improved BCVA in 5 eyes and a stable BCVA in 1 eye. Laser photocoagulation is necessary and effective treatment for retinal vascular tumor. After laser photocoagulation, retinal vascular tumor-related ERM spontaneously released in 75% of the cases, without complication and surgical intervention.

Yazici AT, Alagoz N, Celik HU, Bozkurt E, Alagoz C, Cakir M, Cekic O, Yilmaz OF (2011) Idiopathic and secondary epiretinal membranes: do they differ in terms of morphology? An optical coherence tomography-based study. Retina 31(4):779–784. https://doi.org/10.1097/IAE.0b013e3181ef8786CrossRefPubMed

Appiah AP, Hirose T (1989) Secondary causes of premacular fibrosis. Ophthalmology 96(3):389–392. https://doi.org/10.1016/S0161-6420(89)32881-8CrossRefPubMed

Ting FS, Kwok AK (2005) Treatment of epiretinal membrane: an update. Hong Kong Med J 11(6):496–502PubMed

Meyer CH, Rodrigues EB, Mennel S, Schmidt JC, Kroll P (2004) Spontaneous separation of epiretinal membrane in young subjects: personal observations and review of the literature. Graefes Arch Clin Exp Ophthalmol 242(12):977–985. https://doi.org/10.1007/s00417-004-0934-7CrossRefPubMed

Byon IS, Pak GY, Kwon HJ, Kim KH, Park SW, Lee JE (2015) Natural history of idiopathic epiretinal membrane in eyes with good vision assessed by spectral-domain optical coherence tomography. Ophthalmologica 234(2):91–100. https://doi.org/10.1159/000437058CrossRefPubMed

Yang HS, Hong JW, Kim YJ, Kim JG, Joe SG (2014) Characteristics of spontaneous idiopathic epiretinal membrane separation in spectral domain optical coherence tomography. Retina 34(10):2079–2087. https://doi.org/10.1097/IAE.0000000000000199CrossRefPubMed

Nomoto H, Matsumoto C, Arimura E, Okuyama S, Takada S, Hashimoto S, Shimomura Y (2013) Quantification of changes in metamorphopsia and retinal contraction in eyes with spontaneous separation of idiopathic epiretinal membrane. Eye (Lond) 27(8):924–930. https://doi.org/10.1038/eye.2013.108CrossRef

Kida T, Morishita S, Fukumoto M, Sato T, Oku H, Ikeda T (2017) Long-term evaluation of spontaneous release of epiretinal membrane and its possible pathogenesis. Clin Ophthalmol 11:1607–1610. https://doi.org/10.2147/opth.S146692CrossRefPubMedPubMedCentral

Murata T, Koga H, Fujita H, Noguchi R, Miura M, Kimura J (2007) Spontaneous separation of thick epiretinal membrane after photocoagulation for Leber’s multiple miliary aneurysms. Jpn J Ophthalmol 51(1):78–79. https://doi.org/10.1007/s10384-006-0390-5CrossRefPubMed

10.

Bushuev AV, Andreev AN, Svetozarskiy SN (2018) Spontaneous separation of secondary epiretinal membrane. Vestn oftalmol 134(2):73–77. https://doi.org/10.17116/oftalma2018134273-77CrossRefPubMed

11.

Sugimoto M, Sasoh M, Ito Y, Miyamura M, Uji Y, Chujo S (2002) A case of Coats’ disease with a peeling of premacular fibrosis after photocoagulation. Acta Ophthalmol Scand 80(1):96–97. https://doi.org/10.1034/j.1600-0420.2002.800119.xCrossRefPubMed

12.

Kolomeyer AM, Eller AW, Martel JN (2016) Spontaneous resolution of macular epiretinal membranes after fluorescein potentiated argon laser treatment of Von Hippel-Lindau associated retinal hemangiomas: case report and review of literature. Retin Cases Brief Rep 10(2):145–150. https://doi.org/10.1097/ICB.0000000000000206CrossRefPubMed

13.

Manjandavida FP, Shields CL, Kaliki S, Shields JA (2014) Cryotherapy-induced release of epiretinal membrane associated with retinal vasoproliferative tumor: analysis of 16 cases. Retina 34(8):1644–1650. https://doi.org/10.1097/IAE.0000000000000137CrossRefPubMed

14.

Holladay JT (2004) Visual acuity measurements. J Cataract Refract Surg 30(2):287–290. https://doi.org/10.1016/j.jcrs.2004.01.014CrossRefPubMed

15.

van Overdam K (2020) Vitreoschisis-induced vitreous cortex remnants: missing link in proliferative vitreoretinopathy. Acta Ophthalmol 98(2):e261–e262. https://doi.org/10.1111/aos.14216CrossRefPubMed

16.

Gandorfer ASRG, Haritoglou C, Kampik A (2014) III.C. Pathology of vitreomaculopathies. In: Sebag J (ed) Vitreous. Springer, New York

17.

Asato R, Yoshida S, Ogura A, Nakama T, Ishikawa K, Nakao S, Sassa Y, Enaida H, Oshima Y, Ikeo K, Gojobori T, Kono T, Ishibashi T (2013) Comparison of gene expression profile of epiretinal membranes obtained from eyes with proliferative vitreoretinopathy to that of secondary epiretinal membranes. Plos One 8(1):e54191. https://doi.org/10.1371/journal.pone.0054191

18.

Yoshimura T, Sonoda KH, Sugahara M, Mochizuki Y, Enaida H, Oshima Y, Ueno A, Hata Y, Yoshida H, Ishibashi T (2009) Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases. PLoS One 4(12):ARTN e8158. https://doi.org/10.1371/journal.pone.0008158CrossRef

19.

Edwards MM, McLeod DS, Grebe R, Heng C, Lefebvre O, Lutty GA (2011) Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice. BMC Dev Biol 11:60. https://doi.org/10.1186/1471-213X-11-60CrossRefPubMedPubMedCentral

20.

Gariano RF, Sage EH, Kaplan HJ, Hendrickson AE (1996) Development of astrocytes and their relation to blood vessels in fetal monkey retina. Invest Ophthalmol Vis Sci 37(12):2367–2375PubMed

21.

Chen W, Shen X, Zhang P, Xu G, Jiang R, Huang X, Zhang Y, Chang Q (2019) Clinical characteristics, long-term surgical outcomes, and prognostic factors of epiretinal membrane in young patients. Retina 39(8):1478–1487. https://doi.org/10.1097/IAE.0000000000002202CrossRefPubMed

22.

Benhamou N, Massin P, Spolaore R, Paques M, Gaudric A (2002) Surgical management of epiretinal membrane in young patients. Am J Ophthalmol 133(3):358–364. https://doi.org/10.1016/s0002-9394(01)01422-2CrossRefPubMed

23.

Sanchez-Vicente JL, Contreras-Diaz M, Rueda T, Rodriguez de la Rua-Franch E, Molina-Socola FE, Vital-Berral C, Alfaro-Juarez A, Lopez-Herrero F, Munoz-Morales A (2016) Combined hamartoma of the retina and retinal pigment epithelium in a patient with Gorlin syndrome: spontaneous partial resolution of traction caused by epiretinal membrane. Case Rep Ophthalmol Med 2016:2312196. https://doi.org/10.1155/2016/2312196CrossRefPubMedPubMedCentral

24.

Gupta A, Gopal L, Biswas J (2012) Spontaneous separation of inflammatory epiretinal membrane in a patient with toxoplasmic retinochoroiditis. Oman J Ophthalmol 5(1):64–65. https://doi.org/10.4103/0974-620X.94786CrossRefPubMedPubMedCentral

25.

Mansour AM, Mansour HA, Arevalo JF (2014) Spontaneous release of epiretinal membrane in a young weight-lifting athlete by presumed central rupture and centrifugal pull. Clin Ophthalmol 8:2243–2250. https://doi.org/10.2147/opth.S74163CrossRefPubMedPubMedCentral

26.

Lee R, Wong TY, Sabanayagam C (2015) Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond) 2:17. https://doi.org/10.1186/s40662-015-0026-2CrossRef

27.

Imasawa M, Iijima H (2009) Release of vitreomacular traction following retinal photocoagulation in an eye with branch retinal vein occlusion. Int Ophthalmol 29(1):63–65. https://doi.org/10.1007/s10792-007-9166-2CrossRefPubMed

28.

Han JW, Lyu J, Park YJ, Jang SY, Park TK (2015) Wnt/beta-catenin signaling mediates regeneration of retinal pigment epithelium after laser photocoagulation in mouse eye. Invest Ophthalmol Vis Sci 56(13):8314–8324. https://doi.org/10.1167/iovs.15-18359CrossRefPubMed

29.

Hisatomi T, Sakamoto T, Yamanaka I, Sassa Y, Kubota T, Ueno H, Ohnishi Y, Ishibashi T (2002) Photocoagulation-induced retinal gliosis is inhibited by systemically expressed soluble TGF-beta receptor type II via adenovirus mediated gene transfer. Lab Investig 82(7):863–870. https://doi.org/10.1097/01.Lab.0000018829.49754.DdCrossRefPubMed

Title: Photocoagulation-associated spontaneous release of epiretinal membrane secondary to retinal vascular tumor: case series of 8 cases
Authors: Xinyi Ding
Jingli Guo
Gezhi Xu
Wei Liu
Publication date: 01-03-2022
Publisher: Springer London
Keywords: Retinal Detachment
Vascular Tumor
Peeling
Vascular Tumor
Laser
Published in: Lasers in Medical Science / Issue 2/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03351-9

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Photocoagulation-associated spontaneous release of epiretinal membrane secondary to retinal vascular tumor: case series of 8 cases

Abstract

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