Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 9/2021

01-12-2021 | Hyperpigmentation | Original Article

Comparison of carboxy therapy and fractional Q-switched ND:YAG laser on periorbital dark circles treatment: a clinical trial

Authors: Mohammad Ali Nilforoushzadeh, Maryam Heidari-Kharaji, Shiva Alavi, Sara Zolghadr, Mona Mahmoudbeyk, Nahid Nikkhah

Published in: Lasers in Medical Science | Issue 9/2021

Login to get access

Abstract

Treatment of the periorbital dark circles (PDCs) is a current challenge, with most treatment methods failing to yield promising results. The effectiveness of two common methods for periorbital dark circle treatment was compared in 28 patients with PDC. The patients were randomly divided into two groups of equal numbers: the first group received carboxy therapy, and the second group fractional 10,64 nm Q-switched Nd:YAG laser. In the carboxy therapy group, the treatment was performed six times, with 1-week intervals between sessions. In the group treated by Nd:YAG laser, the treatment was conducted in four sessions, with 1-month intervals between sessions. The results were evaluated through biometric evaluation, scoring on the visual analog scale (VAS) by both physicians and patients, and patients’ satisfaction. Side effects of the treatments were also evaluated. The results showed that both carboxy therapy and Nd:YAG laser are effective in the treatment of periorbital dark circles, but carboxy therapy is significantly more effective. An increase in the skin lightness and a decrease in the melanin content of the periorbital skin was observed in the group receiving carboxy therapy, and these changes were more pronounced in this group compared to the group of Nd:YAG laser. In addition, side effects, such as erythema and post-inflammatory hyperpigmentation, were less in carboxy therapy than in Nd:YAG laser. Furthermore, the procedure was less expensive and easier to perform compared to Nd:YAG laser. Carboxy therapy is significantly more effective than Nd:YAG laser in PDC treatment.
Trial registration: IRCT20080901001159N24
Literature
1.
Roh MR, Chung KY (2009) Infraorbital dark circles: definition, causes, and treatment options. Dermatol Surg 35(8):1163–1171CrossRef
2.
Nilforoushzadeh MA et al (2017) Fractional carbon dioxide laser and its combination with subcision in improving atrophic acne scars. Adv Biomed Res 1(6):20
3.
Nilforoushzadeh MA et al (2020) A comparative study of the efficacy of fractional neodymium-doped yttrium aluminum garnet (Nd: YAG) laser therapy alone and in combination with erbium: YAG laser therapy: tracing and objective measurement of melanin index in macular amyloidosis. Lasers Med Sci 35:1171–1177
4.
Lowe N et al (1996) Infraorbital pigmented skin. Preliminary observations of laser therapy. Am J Ophthalmol 121(2):237CrossRef
5.
Watanabe S, Nakai K, Ohnishi T (2006) Condition known as “dark rings under the eyes” in the japanese population is a kind of dermal melanocytosis which can be successfully treated by Q-switched ruby laser. Dermatol Surg 32(6):785–789PubMed
6.
Brandi C et al (2001) Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations. Aesthet Plast Surg 25(3):170–174CrossRef
7.
Nilforooshzadeh MA et al (2020) Effective combination therapy with high concentration of Minoxidil and Carboxygas in resistant Androgenetic alopecia: report of nine cases. J Cosmet Dermatol 19(11):1–5
8.
Vrcek I, Ozgur O, Nakra T (2016) Infraorbital dark circles: a review of the pathogenesis, evaluation and treatment. J Cutan Aesthet Surg 9(2):65CrossRef
9.
Paolo F et al (2012) Periorbital area rejuvenation using carbon dioxide therapy. J Cosmet Dermatol 11(3):223–228CrossRef
10.
Roberts WE (2014) Periorbital hyperpigmentation: review of etiology, medical evaluation, and aesthetic treatment. J Drugs Dermatol 13(4):472PubMed
11.
Arora P et al (2012) Lasers for treatment of melasma and post-inflammatory hyperpigmentation. J Cutan Aesthet Surg 5(2):93CrossRef
12.
Chan NP et al (2010) A case series of facial depigmentation associated with low fluence Q-switched 1,064 nm Nd: YAG laser for skin rejuvenation and melasma. Lasers Surg Med 42(8):712–719CrossRef
13.
Friedmann DP, Goldman MP (2015) Dark circles: etiology and management options. Clin Plast Surg 42(1):33–50CrossRef
14.
Hassan AM et al (2016) Treatment of periorbital dark circles: Comparative study of chemical peeling with a combination of trichloroacetic acid and lactic acid versus carboxytherapy. J Surg Dermatol 1(2):108–115CrossRef
15.
Ahmed NA, Mohammed SS, Fatani MI (2019) Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy. J Cosmet Dermatol 18(1):169–175CrossRef
16.
Freitag FM, Cestari TF (2007) What causes dark circles under the eyes? J Cosmet Dermatol 6(3):211–215CrossRef
17.
Xu T-H et al (2016) Treatment of infraorbital dark circles using 694-nm fractional Q-switched ruby laser. Lasers Med Sci 31(9):1783–1787CrossRef
18.
Vanaman Wilson MJ et al (2018) Prospective studies of the efficacy and safety of the picosecond 755, 1,064, and 532 nm lasers for the treatment of infraorbital dark circles. Lasers Surg Med 50(1):45–50CrossRef
19.
Xu TH et al (2011) Treatment of infraorbital dark circles using a low-fluence Q-switched 1,064-nm laser. Dermatol Surg 37(6):797–803PubMed
20.
Goldberg DJ (1993) Benign pigmented lesions of the skin: treatment with the Q-switched ruby laser. J Dermatol Surg Oncol 19(4):376–379CrossRef
21.
Terakawa M et al (2007) Enhanced angiogenesis in grafted skins by laser-induced stress wave-assisted gene transfer of hepatocyte growth factor. J Biomed Opt 12(3):034031CrossRef
22.
Papadavid E, Katsambas A (2003) Lasers for facial rejuvenation: a review. Int J Dermatol 42(6):480–487CrossRef
23.
Kwon HH et al (2019) Combined treatment of melasma involving low-fluence Q-switched Nd: YAG laser and fractional microneedling radiofrequency. J Dermatol Treat 30(4):352–356CrossRef
24.
Momosawa A et al (2008) Combined therapy using Q-switched ruby laser and bleaching treatment with tretinoin and hydroquinone for periorbital skin hyperpigmentation in Asians. Plast Reconstr Surg 121(1):282–288CrossRef
Metadata
Title
Comparison of carboxy therapy and fractional Q-switched ND:YAG laser on periorbital dark circles treatment: a clinical trial
Authors
Mohammad Ali Nilforoushzadeh
Maryam Heidari-Kharaji
Shiva Alavi
Sara Zolghadr
Mona Mahmoudbeyk
Nahid Nikkhah
Publication date
01-12-2021
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 9/2021
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-021-03274-5

Other articles of this Issue 9/2021

Lasers in Medical Science 9/2021 Go to the issue

Original Article

Low level laser therapy, Er,Cr:YSGG laser and fluoride varnish for treatment of dentin hypersensitivity after periodontal surgery: A randomized clinical trial

Original Article

Study on the mechanism of photodynamic therapy mediated by 5-aminoketovalerate in human ovarian cancer cell line

Original Article

Transoral laser microsurgery: feasibility of a new exoscopic HD-3D system coupled with free beam or fiber laser

Original Article

Comparison of 532-nm GreenLight HPS laser with 980-nm diode laser vaporization of the prostate in treating patients with lower urinary tract symptom secondary to benign prostatic hyperplasia: a meta-analysis

Original Article

Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens

Review Article

Effects of laser therapy on periorbital hyperpigmentation: a systematic review on current studies