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01-02-2022 | Laser | Original Article

Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions

Authors: Bo Wang, Ying Huang

Published in: Lasers in Medical Science | Issue 1/2022

Abstract

Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor’s microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under photothermal conditions, mAb-CD163/Au inhibited tumor invasion by killing M2 macrophages in vitro. After exposure to near-infrared (NIR) laser, mAb-CD163/Au inhibited tumor growth in vivo. The gold nanoparticles were modified to target M2 macrophages. Under NIR laser irradiation, mAb-CD163/Au achieved antitumor effects by killing M2 macrophages in vitro and in vivo.

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Title: Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions
Authors: Bo Wang
Ying Huang
Publication date: 01-02-2022
Publisher: Springer London
Keyword: Laser
Published in: Lasers in Medical Science / Issue 1/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03248-7

At a glance: The STEP trials

Springer Medicine

Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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