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Lasers in Medical Science
Published in: Lasers in Medical Science 1/2022

01-02-2022 | Original Article

Photobiomodulation and diffusing optical fiber on spinal cord’s impact on nerve cells from normal spinal cord tissue in piglets

Authors: Xiaoshuang Zuo, Zhuowen Liang, Jiawei Zhang, Shuang Wang, Qiao Zheng, Yangguang Ma, Penghui Li, Tan Ding, Xueyu Hu, Zhe Wang

Published in: Lasers in Medical Science | Issue 1/2022

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Abstract

Experts have proven that photobiological regulation therapy for spinal cord injury promotes the spinal repair following injury. The traditional irradiation therapy mode is indirect (percutaneous irradiation), which could significantly lower the effective use of light energy. In earlier studies, we developed an implantable optical fiber that one can embed above the spinal cord lamina, and the light directly is cast onto the surface of the spinal cord in a way that can dramatically improve energy use. Nonetheless, it remains to be seen whether near-infrared light diffused by embedded optical fiber can have side effects on the surrounding nerve cells. Given this, we implanted optical fiber on the lamina of a normal spinal cord to observe the structural integrity of the tissue using morphological staining; we also used immunohistochemistry to detect inflammatory factors. Considering the existing studies, we meant to determine that the light energy diffused by embedded optical fiber has no side effect on the normal tissue. The results of this study will lay a foundation for the clinical application of the treatment of spinal cord injury by near-infrared light irradiation.
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Metadata
Title
Photobiomodulation and diffusing optical fiber on spinal cord’s impact on nerve cells from normal spinal cord tissue in piglets
Authors
Xiaoshuang Zuo
Zhuowen Liang
Jiawei Zhang
Shuang Wang
Qiao Zheng
Yangguang Ma
Penghui Li
Tan Ding
Xueyu Hu
Zhe Wang
Publication date
01-02-2022
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 1/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-020-03231-8

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