Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 9/2020

01-12-2020 | Testosterone | Original Article

Determination of cadmium induced acute and chronic reproductive toxicity with Raman spectroscopy

Authors: Disheng Liu, Jianghou Wan, Zhenzhen Liu, Zhiyu Zhao, Guangru Zhang, Yufang Leng

Published in: Lasers in Medical Science | Issue 9/2020

Login to get access

Abstract

Cadmium (Cd) is one of the toxic heavy metals which is confirmed to be related to male sterile. Here, confocal Raman spectroscopy was employed to detect biomolecular composition and changes in testis under acute and chronic Cd treatment. Specific Raman shifts associated with mitochondria, nucleic acids, proteins, lipids, and cholesterol were identified which were distinguishing among groups undergoing different Cd treatment times. Supporting evidences were provided by conventional experimental detections. The relevant biochemical parameters, pathological changes, and protein expression related to testosterone synthesis were all changed and consistent with Raman spectrum information. In conclusion, confocal Raman spectroscopy presents a reliable data and provides a novel method which is expected to be a promising strategy in reproduction toxicity research.
Literature
1.
Shi W, Zhao X, Han Y, Che Z et al (2016) Ocean acidification increases cadmium accumulation in marine bivalves: a potential threat to seafood safety. Sci Rep 6:20197
2.
Chargui A, Zekri S, Jacquillet G, Rubera I et al (2011) Cadmium-induced autophagy in rat kidney: an early biomarker of subtoxic exposure. Toxicol Sci: an official journal of the Society of Toxicology 121:31–42
3.
Baba H, Tsuneyama K, Yazaki M, Nagata K et al (2013) The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression. Mod Pathol 26:1228–1234
4.
Wang B, Luo Q, Shao C, Li X et al (2013) The late and persistent pathogenic effects of cadmium at very low levels on the kidney of rats. Dose-Response 11:60–81
5.
Wang YX, Sun Y, Huang Z, Wang P et al (2016) Associations of urinary metal levels with serum hormones, spermatozoa apoptosis and sperm DNA damage in a Chinese population. Environ Int 94:177–188
6.
Li XH, Wang LR, Li YH, Fu JL et al (2016) Tyrosine phosphorylation of dihydrolipoamide dehydrogenase as a potential cadmium target and its inhibitory role in regulating mouse sperm motility. Toxicology 357:52–64
7.
Paidi SK, Diaz PM, Dadgar S, Jenkins SV et al (2019) Label-free Raman spectroscopy reveals signatures of radiation resistance in the tumor microenvironment. Cancer Res 79:2054–2064
8.
Meyer S, Heinsohn G, Wolber R, Portner R, Nierle J (2015) Confocal Raman investigation of diffusion processes in monolithic type transdermal drug delivery systems. Drug Deliv 22:1103–1110
9.
Le DV, Le VT, Nguyen VC, Jiang JH, Dang KT (2018) Immunoreaction-mediated aggregation of gold nanoparticles for sensitive and selective assay of hepatitis B surface antigen. J Nanosci Nanotechnol 18:1083–1088
10.
Liu YF, Zhu Y, Di L, Osterberg EC et al (2014) Raman spectroscopy as an ex vivo noninvasive approach to distinguish complete and incomplete spermatogenesis within human seminiferous tubules. Fertil Steril 102:54–60.e2
11.
de Jong BWD, Brazao CAD, Stoop H, Wolffenbuttel KP et al (2004) Raman spectroscopic analysis identifies testicular microlithiasis as intratubular hydroxyapatite. J Urol 171:92–96
12.
Chen J, Xiao HJ, Qi T, Chen DL et al (2015) Rare earths exposure and male infertility: the injury mechanism study of rare earths on male mice and human sperm. Environ Sci Pollut R 22:2076–2086
13.
Duan P, Liu BS, Morais CLM, Zhao J et al (2019) 4-Nonylphenol effects on rat testis and sertoli cells determined by spectrochemical techniques coupled with chemometric analysis. Chemosphere 218:64–75
14.
Amaral S, Da Costa R, Wubbeling F, Redmann K, Schlatt S (2018) Raman micro-spectroscopy analysis of different sperm regions: a species comparison. Mol Hum Reprod 24:185–202
15.
Perry DA, Salvin JW, Romfh P, Chen PL et al (2017) Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med 9:eaan0117
16.
Dukor RK (2006) Vibrational spectroscopy in the detection of cancer
17.
Patel II, Martin FL (2010) Discrimination of zone-specific spectral signatures in normal human prostate using Raman spectroscopy. Analyst 135:3060–3069
18.
Ruiz-Chica AJ, Medina MA, Sanchez-Jimenez F, Ramirez FJ (2004) Characterization by Raman spectroscopy of conformational changes on guanine-cytosine and adenine-thymine oligonucleotides induced by aminooxy analogues of spermidine. J Raman Spectrosc 35:93–100
19.
Li Y, Huang W, Pan J, Ye Q et al (2015) Rapid detection of nasopharyngeal cancer using Raman spectroscopy and multivariate statistical analysis. Mol Clin Oncol 3:375–380
20.
Ishimaru Y, Oshima Y, Imai Y, Iimura T et al (2018) Raman spectroscopic analysis to detect reduced bone quality after sciatic neurectomy in mice. Molecules 23:3081
21.
Rangan S, Kamal S, Konorov SO, Schulze HG et al (2018) Types of cell death and apoptotic stages in Chinese hamster ovary cells distinguished by Raman spectroscopy. Biotechnol Bioeng 115:401–412
22.
Christy AA, Egeberg PK, Ostensen ET (2003) Simultaneous quantitative determination of isolated trans fatty acids and conjugated linoleic acids in oils and fats by chernometric analysis of the infrared profiles. Vib Spectrosc 33:37–48
23.
Li SX, Chen QY, Zhang YJ, Liu ZM et al (2012) Detection of nasopharyngeal cancer using confocal Raman spectroscopy and genetic algorithm technique. J Biomed Opt 17:125003
24.
Czamara K, Majzner K, Pacia MZ, Kochan K et al (2015) Raman spectroscopy of lipids: a review. J Raman Spectrosc 46:4–20
25.
Kulkarni A, Kim B, Dugasani SR, Joshirao P et al (2013) A novel nanometric DNA thin film as a sensor for alpha radiation. Sci Rep 3:2062
26.
Marzec KM, Rygula A, Gasior-Glogowska M, Kochan K et al (2015) Vascular diseases investigated ex vivo by using Raman, FT-IR and complementary methods. Pharmacol Rep 67:744–750
27.
Wang L, Zhang ZP, Huang LJ, Li WM et al (2014) Evaluation of Raman spectroscopy for diagnosing EGFR mutation status in lung adenocarcinoma. Analyst 139:455–463
28.
Notingher I, Green C, Dyer C, Perkins E et al (2004) Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy. J R Soc Interface 1:79–90
29.
Bergholt MS, Zheng W, Lin K, Wang JF et al (2015) Characterizing variability of in vivo Raman spectroscopic properties of different anatomical sites of normal colorectal tissue towards cancer diagnosis at colonoscopy. Anal Chem 87:960–966
30.
Kochan K, Maslak E, Krafft C, Kostogrys R et al (2015) Raman spectroscopy analysis of lipid droplets content, distribution and saturation level in non-alcoholic fatty liver disease in mice. J Biophotonics 8:597–609
31.
Faolain OE, Hunter MB, Byrne JM, Kelehan P et al (2005) A study examining the effects of tissue processing on human tissue sections using vibrational spectroscopy. Vib Spectrosc 38:121–127
32.
Niknafs B, Salehnia M, Kamkar M (2015) Induction and determination of apoptotic and necrotic cell death by cadmium chloride in testis tissue of mouse. J Reprod Infertility 16:24–29
33.
Li R, Luo X, Li L, Peng Q et al (2016) The protective effects of melatonin against oxidative stress and inflammation induced by acute cadmium exposure in mice testis. Biol Trace Elem Res 170:152–164
34.
Benoff S, Auborn K, Marmar JL, Hurley IR (2008) Link between low-dose environmentally relevant cadmium exposures and asthenozoospermia in a rat model. Fertil Steril 89:e73–e79
35.
Singh KP, Kumari R, Pevey C, Jackson D, DuMond JW (2009) Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Lett 279:84–92
36.
Blanco A, Moyano R, Lopez AMM, Blanco C et al (2010) Preneoplastic and neoplastic changes in the Leydig cells population in mice exposed to low doses of cadmium. Toxicol Ind Health 26:451–457
37.
Ren XM, Wang GG, Xu DQ, Luo K et al (2012) The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice. Food Chem Toxicol 50:3521–3529
38.
Liu G, Zou H, Luo TW, Long MF et al (2016) Caspase-dependent and caspase-independent pathways are involved in cadmium-induced apoptosis in primary rat proximal tubular cell culture. PLoS One 11:e0166823
39.
Al-Assaf AH, Alqahtani AM, Alshatwi AA, Syed NA et al (2013) Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3. Environ Toxicol Pharmacol 36:1033–1039
40.
Nair AR, Lee WK, Smeets K, Swennen Q et al (2015) Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney. Arch Toxicol 89:2273–2289
Metadata
Title
Determination of cadmium induced acute and chronic reproductive toxicity with Raman spectroscopy
Authors
Disheng Liu
Jianghou Wan
Zhenzhen Liu
Zhiyu Zhao
Guangru Zhang
Yufang Leng
Publication date
01-12-2020
Publisher
Springer London
Keyword
Testosterone
Published in
Lasers in Medical Science / Issue 9/2020
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-020-02976-6

Other articles of this Issue 9/2020

Lasers in Medical Science 9/2020 Go to the issue

Original Article

Initial experience in combined ultra-mini percutaneous nephrolithotomy with the use of 120-W laser and the anti-retropulsion “Moses effect”: the future of percutaneous nephrolithotomy?

Brief Report

Transoral laryngeal videosurgery under the direct guidance of narrow band imaging: a preliminary report

Original Article

Dose-dependent effect of the pulsed Nd:YAG laser in the treatment of crushed sciatic nerve in Wister rats: an experimental model

Review Article

ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases—an integrative literature review

Brief Report

Resumption of laser/IPL skin services post COVID-19 lockdown—British Medical Laser Association (BMLA) guidance document

Original Article

Irradiation with blue light-emitting diode enhances osteogenic differentiation of stem cells from the apical papilla