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01-08-2020 | Rheumatoid Arthritis | Original Article

Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis

Authors: Morgana Neves, Ana Caroline Barbosa Retameiro, Alana Ludemila de Freitas Tavares, Aline Reginato, Rafael Andrade Menolli, Taciane Stein da Silva Leal, Lucinéia de Fátima Chasko Ribeiro, Gladson Ricardo Flor Bertolini

Published in: Lasers in Medical Science | Issue 6/2020

Abstract

Rheumatoid arthritis denotes hyperplasia and intense inflammatory process. Treatment involves exercise protocols and use of resources such as low-level laser therapy (LLLT) to modulate the inflammatory process and maintain physical capacity. The objective was to investigate whether treatment with LLLT and exercise modulates the inflammatory process and peripheral functionality. Sample is composed of 128 male rats, separated into three groups, control, treated and untreated, in the acute and chronic period of the disease with 64 animals in each group, divided into 8 subgroups with n = 8. The animals were immunized with injection at the base of the tail and 7 days after intra-articular injection with complete Freund adjuvant (CFA) for lesion groups, and saline solution for the controls. Joint disability was evaluated by PET (paw elevation time) and joint edema and treated with LLLT and/or resisted stair climbing exercise. Normality Shapiro-Wilk test, ANOVA mixed for the functional analyses, and ANOVA one-way for the variables of cellular differentiation, with Bonferroni post hoc, p = 5% were used. For the evaluations of joint disability and nociception, there was a significant difference between the evaluations, the groups, and the interaction groups-evaluations. The treated groups showed recovery of functionality; it is still verified that laser therapy increased the nociceptive threshold of the chronic inflammatory period, and the exercise reflected in significant functional improvement and modulation of the inflammatory process both in the acute and chronic periods. LLLT, resistance exercise, or a combination of treatments had a positive effect on the modulation of the inflammatory process, reducing the migration of leukocytes, in addition to helping the return of peripheral functionality by reducing joint disability in a model of rheumatoid arthritis induced by CFA in rats.

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Title: Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis
Authors: Morgana Neves
Ana Caroline Barbosa Retameiro
Alana Ludemila de Freitas Tavares
Aline Reginato
Rafael Andrade Menolli
Taciane Stein da Silva Leal
Lucinéia de Fátima Chasko Ribeiro
Gladson Ricardo Flor Bertolini
Publication date: 01-08-2020
Publisher: Springer London
Keywords: Rheumatoid Arthritis
Laser
Published in: Lasers in Medical Science / Issue 6/2020
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-019-02905-2

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Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis

Abstract

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