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01-04-2018 | Original Article

In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy

Authors: Pam Wen Lung, Vamshi Krishna Tippavajhala, Thiago de Oliveira Mendes, Claudio A. Téllez-Soto, Desirée Cigaran Schuck, Carla Abdo Brohem, Marcio Lorencini, Airton Abrahão Martin

Published in: Lasers in Medical Science | Issue 3/2018

Abstract

This research work mainly deals with studying qualitatively the changes in the dermal collagen of two forms of striae distensae (SD) namely striae rubrae (SR) and striae albae (SA) when compared to normal skin (NS) using confocal Raman spectroscopy. The methodology includes an in vivo human skin study for the comparison of confocal Raman spectra of dermis region of SR, SA, and NS by supervised multivariate analysis using partial least squares discriminant analysis (PLS-DA) to determine qualitatively the changes in dermal collagen. These groups are further analyzed for the extent of hydration of dermal collagen by studying the changes in the water content bound to it. PLS-DA score plot showed good separation of the confocal Raman spectra of dermis region into SR, SA, and NS data groups. Further analysis using loading plot and S-plot indicated the participation of various components of dermal collagen in the separation of these groups. Bound water content analysis showed that the extent of hydration of collagen is more in SD when compared to NS. Based on the results obtained, this study confirms the active involvement of dermal collagen in the formation of SD. It also emphasizes the need to study quantitatively the role of these various biochemical changes in the dermal collagen responsible for the variance between SR, SA, and NS.

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Title: In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy
Authors: Pam Wen Lung
Vamshi Krishna Tippavajhala
Thiago de Oliveira Mendes
Claudio A. Téllez-Soto
Desirée Cigaran Schuck
Carla Abdo Brohem
Marcio Lorencini
Airton Abrahão Martin
Publication date: 01-04-2018
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 3/2018
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-017-2431-3

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In vivo study of dermal collagen of striae distensae by confocal Raman spectroscopy

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