Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 8/2017

01-11-2017 | Original Article

Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

Authors: Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Lucarini, Francesca Cialdai, Leonardo Vignali, Carla Ghelardini, Monica Monici

Published in: Lasers in Medical Science | Issue 8/2017

Login to get access

Abstract

Over the past three decades, physicians have used laser sources for the management of different pain conditions obtaining controversial results that call for further investigations. In order to evaluate the pain relieving possibilities of photobiomodulation therapy (PBMT), we tested two near infrared (NIR) laser systems, with different power, against various kinds of persistent hyperalgesia animal models. In rats, articular pain was reproduced by the intra-articular injection of sodium monoiodoacetate (MIA) and complete Freund’s adjuvant (CFA), while compressive neuropathy was modelled by the chronic constriction injury of the sciatic nerve (CCI). In MIA and CFA models, (NIR) laser (MLS-Mphi, ASA S.r.l., Vicenza, Italy) application was started 14 days after injury and was performed once a day for a total of 13 applications. In MIA-treated animals, the anti-hyperalgesic effect of laser began 5 min after treatment and vanished after 60 min. The subsequent applications evoked similar effects. In CFA-treated rats, laser efficacy started 5 min after treatment and disappeared after 180 min. In rats that underwent CCI, two treatment protocols with similar fluence but different power output were tested using a new experimental device called Multiwave Locked System laser (MLS-HPP). Treatments began 7 days after injury and were performed during 3 weeks for a total of 10 applications. Both protocols reduced mechanical hyperalgesia and hindlimb weight bearing alterations until 60 min after treatment with a higher efficacy recorded for the animals treated using the higher power output. In conclusion, this study supports laser therapy as a potential treatment for immediate relief of chronic articular or neuropathic pain.
Literature
1.
Hall GC, Carroll D, Parry D, McQuay HJ (2006) Epidemiology and treatment of neuropathic pain: the UK primary care perspective. Pain 122:156–162CrossRefPubMed
2.
Voscopoulos C, Lema M (2010) When does acute pain become chronic? Br J Anaesth 105(Supp1):i69–i85CrossRefPubMed
3.
Woolf CJ (2004) Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 140:441–451CrossRefPubMed
4.
5.
6.
Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R (2008) Opioid complications and side effects. Pain Physician 11(2 Suppl):S105–S120PubMed
7.
8.
Torrance N, Ferguson JA, Afolabi E, Bennett MI, Serpell MG, Dunn KM, Smith BH (2013) Neuropathic pain in the community: more under-treated than refractory? Pain 154:690–699CrossRefPubMedPubMedCentral
9.
Chow RT, Barnsley LB, Heller GZ (2006) The effect of 300mW, 830nm laser on chronic neck pain: a double-blind, randomized, placebo-controlled study. Pain 124:201–210CrossRefPubMed
10.
Enwemeka CS, Parker JC, Dowdy DC, Harkness EE, Sanford LE, Woodruff LD (2004) The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 22:323–329CrossRefPubMed
11.
Plog FMW (1980) Biophysical application of the laser beam. In: Koebner HK (ed) Lasers in medicine. Wiley, Chichester, pp 21–37
12.
McGrath JC, Lilley E (2015) Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. Br J Pharmacol 172:3189–3193CrossRefPubMedPubMedCentral
13.
Guingamp C, Gegout-Pottie P, Philippe L, Terlain B, Netter P, Gillet P (1997) Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry. Arthritis Rheum 40(9):1670–1679CrossRefPubMed
14.
Di Cesare Mannelli L, Bani D, Bencini A, Brandi ML, Calosi L, Cantore M, Carossino AM, Ghelardini C, Valtancoli B, Failli P (2013) Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats. Mediat Inflamm. doi:10.​1155/​2013/​905360
15.
Butler SH, Godefroy F, Besson JM, Weil-Fugazza J (1992) A limited arthritic model for chronic pain studies in the rat. Pain 48:73–81CrossRefPubMed
16.
Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation those seen in man. Pain 33:87–107CrossRefPubMed
17.
Leighton G, Rodriguez R, Hill R, Hughes J (1988) Kappa-opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat. Br J Pharmacol 93(3):553–560CrossRefPubMedPubMedCentral
18.
Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE (2003) Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthr Cartil 11:821–830CrossRefPubMed
19.
Brouwers H, von Hegedus J, Toes R, Kloppenburg M, Ioan-Facsinay A (2015) Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis. Best Pract Res Clin Rheumatol 29(6):741–755CrossRefPubMed
20.
Garver MJ, Focht BC, Dials J, Rose M, Lucas AR, Devor ST, Emery CF, Hackshaw KV, Rejesky WJ (2014) Weight status and differences in mobility performance, pain symptoms, and physical activity in older, knee osteoarthritis patients. Arthritis. doi:10.​1155/​2014/​375909
21.
22.
Lipsky PE (2005) Rheumatoid arthritis. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL (eds) Harrison's principles of internal medicine. McGraw Hill, New York, pp 1968–1977
23.
Combe R, Bramwell S, Field MJ (2004) The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats? Neurosci Lett 370:236–240CrossRefPubMed
24.
Guzman RE, Evans MG, Bove S, Morenko B, Kilgore K (2003) Monoiodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol 31:619–624CrossRefPubMed
25.
Ivanavicius SP, Ball AD, Heapy CG, Westwood FR, Murray F, Read SJ (2007) Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterization. Pain 128:272–282CrossRefPubMed
26.
Aimbire F, Albertini R, Pacheco MT, Castro-Faria-Neto HC, Leonardo PS, Iversen VV, Lopes-Martins RA, Bjordal JM (2006) Low-level laser therapy induces dose-dependent reduction of TNFα levels in acute inflammation. Photomed Laser Surg 24:33–37CrossRefPubMed
27.
Bjordal JM, Lopes-Martins RAB, Iversen VV (2006) A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. Br J Sports Med 40:76–80CrossRefPubMedPubMedCentral
28.
Walker J (1983) Relief from chronic pain by low-power laser irradiation. Neurosci Lett 43:339–344CrossRefPubMed
29.
Hansen HJ, Thorøe U (1990) Low power laser biostimulation of chronic orofacial pain. A double-blind placebo controlled cross-over study in 40 patients. Pain 43(2):169–179CrossRefPubMed
30.
Laakso EL, Cramond T, Richardson C, Galligan JP (1994) Plasma ACTH and â-endorphin levels in response to low level laser therapy (LLLT) for myofascial trigger points. Laser Ther 6:133–142CrossRef
31.
Chow R, Armati P, Laakso EL, Bjordal JM, Baxter GD (2011) Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review. Photomed Laser Surg 29(6):365–381. doi:10.​1089/​pho.​2010.​2928 CrossRefPubMed
32.
Sato T, Kawatani M, Takeshige C, Matsumoto I (1994) Ga-Al-As laser irradiation neuronal activity associated with inflammation. Acupuncture Electro 19:141–151CrossRef
33.
Tsuchiya D, Kawatani M, Takeshige C (1994) Laser irradiation abates neuronal responses to nociceptive stimulation of rat-paw skin. Brain Res Bull 34:369–374CrossRefPubMed
34.
Jimbo K, Noda K, Suzuki H, Yoda K (1998) Suppressive effects of low-power laser irradiation on bradykinin evoked action potentials in cultured murine dorsal root ganglia cells. Neurosci Lett 240:93–96CrossRefPubMed
35.
Bortone F, Santos H, Albertini R, Pesquero J, Costa M, Soiva J (2008) Low-level laser therapy modulates kinin receptors mRNA expression in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation. Int Immunopharmacol 8:206–210CrossRefPubMed
36.
Couture R, Harrisson M, Vianna R, Cloutier F (2001) Kinin receptors in pain and inflammation. Eur J Pharmacol 429:161–176CrossRefPubMed
37.
Kobiela Ketz A, Byrnes KR, Grunberg NE, Kasper CE, Osborne L, Pryor B, Tosini NL, Wu X, Anders JJ (2017) Characterization of macrophage/microglial activation and effect of photobiomodulation in the spinal nerve injury model of neuropathic pain. Pain Med 18(5):932–946
38.
Pacini A, Di Cesare Mannelli L, Bonaccini L, Ronzoni S, Bartolini A, Ghelardini C (2010) Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pain 150(3):542–549CrossRefPubMed
39.
Di Cesare Mannelli L, Ghelardini C, Micheli L, Cialdai F, Vignali L, Fusi F, Monici M (2015) Effect of high power dual wavelength NIR laser emission in a rat model of compressive pain. Energy Health 14:12–17
40.
Masoumipoor M, Jameie SB, Janzadeh A, Nasirinezhad F, Soleimani M, Kerdary M (2014) Effects of 660- and 980-nm low-level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve. Lasers Med Sci 29(5):1593–1598. doi:10.​1007/​s10103-014-1552-1 CrossRefPubMed
Metadata
Title
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat
Authors
Laura Micheli
Lorenzo Di Cesare Mannelli
Elena Lucarini
Francesca Cialdai
Leonardo Vignali
Carla Ghelardini
Monica Monici
Publication date
01-11-2017
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 8/2017
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-017-2284-9

Other articles of this Issue 8/2017

Lasers in Medical Science 8/2017 Go to the issue

Review Article

Efficacy of fractional lasers in treating alopecia: a literature review

Original Article

Curcumin photodynamic effect in the treatment of the induced periodontitis in rats

Abstracts

Abstracts Laser Florence 2017

Original Article

UVA1 vs. narrowband UVB phototherapy in the treatment of palmoplantar pustulosis: a pilot randomized controlled study

Original Article

Enhancement of photodynamic inactivation of Staphylococcus aureus biofilms by disruptive strategies

Original Article

Comparison of photobiomodulation therapy and suprascapular nerve-pulsed radiofrequency in chronic shoulder pain: a randomized controlled, single-blind, clinical trial