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01-01-2015 | Original Article

Effects of weekly LED therapy at 625 nm on the treatment of chronic lower ulcers

Authors: Cláudia Patrícia Cardoso Martins Siqueira, Solange de Paula Ramos, Cynthia A. A. Gobbi, Leonardo Shigaki, Roberto K. Kashimoto, Emerson José Venâncio, Dari de Oliveira Toginho Filho, André G. Castaldin, Alan S. Felinto, Francisco Pereira Silva, Ricardo B. Silva, Ivan Frederico Lupiano Dias

Published in: Lasers in Medical Science | Issue 1/2015

Abstract

The aim of this study was to evaluate the effects of LED therapy associated with compression therapy on chronic venous leg ulcers (CVUs). The study included CVU patients (n = 17, eight men) who were eligible for Unna’s boot treatment. Ulcers were treated on a weekly basis with either LED therapy (625 nm, 4 J/cm²) and an Unna’s boot (LED ulcers, n = 14) or a placebo treatment and an Unna’s boot (control ulcers, n = 14). The total surface area of the ulcers, the relative ulcer area, and the healing rate were recorded over a period of 30 weeks. Ulcer exudates were collected for determination of local tumor necrosis factor alpha (TNF-α) levels. The total area was not significantly different between the LED and control ulcers (P > 0.05, Mann-Whitney U test) throughout the study. However, the relative area indicated that non-healing treatment resistant ulcers (n = 6) persisted in the control group after 19 weeks (P < 0.05, Mann-Whitney U Test). No differences in median healing rate were observed (hazard ratio 0.89, CI 95 %: 0.40–1.98) between LED (15 weeks) and control ulcers (19.5 weeks). No differences in TNF-α levels were detected (P > 0.05, Mann-Whitney U test). The results suggest that LED therapy improved the effectiveness of the Unna’s boot since no refractory ulcer was observed in the LED group after 19 weeks. However, LED therapy did not alter the local secretion of TNF-α nor accelerate wound healing.

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Title: Effects of weekly LED therapy at 625 nm on the treatment of chronic lower ulcers
Authors: Cláudia Patrícia Cardoso Martins Siqueira
Solange de Paula Ramos
Cynthia A. A. Gobbi
Leonardo Shigaki
Roberto K. Kashimoto
Emerson José Venâncio
Dari de Oliveira Toginho Filho
André G. Castaldin
Alan S. Felinto
Francisco Pereira Silva
Ricardo B. Silva
Ivan Frederico Lupiano Dias
Publication date: 01-01-2015
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 1/2015
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1666-5

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Effects of weekly LED therapy at 625 nm on the treatment of chronic lower ulcers

Abstract

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Abstract

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