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01-01-2015 | Original Article

Low-level laser therapy in IL-1β, COX-2, and PGE2 modulation in partially injured Achilles tendon

Authors: Julio Fernandes de Jesus, Diva Denelle Spadacci-Morena, Nayra Deise dos Anjos Rabelo, Carlos Eduardo Pinfildi, Thiago Yukio Fukuda, Helio Plapler

Published in: Lasers in Medical Science | Issue 1/2015

Abstract

This study evaluated IL-1β, COX-2, and PGE2 modulation in partially injured Achilles tendons treated with low-level laser therapy (LLLT). Sixty-five male Wistar rats were used. Sixty were submitted to a direct injury on Achilles tendon and then distributed into six groups: LASER 1 (a single LLLT application), LASER 3 (three LLLT applications), and LASER 7 (seven LLLT applications) and Sham 1, 3, and 7 (the same injury but LLLT applications were simulated). The five remaining animals were allocated at control group (no procedure performed). LLLT (780 nm) was applied with 70 mW of mean power and 17.5 J/cm² of fluency for 10 s, once a day. The tendons were surgically removed and assessed immunohistochemically for IL-1β, COX-2, and PGE2. In comparisons with control (IL-1β: 100.5 ± 92.5 / COX-2: 180.1 ± 97.1 / PGE2: 187.8 ± 128.8) IL-1β exhibited (mean ± SD) near-normal level (p > 0.05) at LASER 3 (142.0 ± 162.4). COX-2 and PGE2 exhibited near-normal levels (p > 0.05) at LASER 3 (COX-2: 176.9 ± 75.4 / PGE2: 297.2 ± 259.6) and LASER 7 (COX-2: 259.2 ± 190.4 / PGE2: 587.1 ± 409.7). LLLT decreased Achilles tendon’s inflammatory process.

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Title: Low-level laser therapy in IL-1β, COX-2, and PGE2 modulation in partially injured Achilles tendon
Authors: Julio Fernandes de Jesus
Diva Denelle Spadacci-Morena
Nayra Deise dos Anjos Rabelo
Carlos Eduardo Pinfildi
Thiago Yukio Fukuda
Helio Plapler
Publication date: 01-01-2015
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 1/2015
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1636-y

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Low-level laser therapy in IL-1β, COX-2, and PGE2 modulation in partially injured Achilles tendon

Abstract

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