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01-03-2014 | Original Article

Protective effect of low-level laser therapy (LLLT) on acute zymosan-induced arthritis

Authors: Fernando Pereira Carlos, Marcelo de Paula Alves da Silva, Eliadna de Lemos Vasconcelos Silva Melo, Maricilia Silva Costa, Stella Regina Zamuner

Published in: Lasers in Medical Science | Issue 2/2014

Abstract

The aim of this study was to evaluate the effect of low-level laser therapy on acute zymosan-induced arthritis, with respect to the laser action on inflammatory cells influx, release of pro-inflammatory mediators, metalloproteinases activity into the joint cavity and the cartilage repair process. Arthritis was induced in male Wistar rats (250–280 g) by intra-articular injection of zymosan (1 mg dissolved in 50 μl of a sterile saline solution) into one rear knee joint. Animals were irradiated immediately, 1 and 2 h after zymosan administration with a semiconductor laser InGaAIP (660 nm, 10 mW, 2.5 J/cm², 10 s). In the positive control group, animals were injected with the anti-inflammatory drug dexamethasone 1 h prior to the zymosan administration. Treatment with laser significantly inhibited leukocytes influx, the release of IL-1 and IL-6 and also the activity of metalloproteinase-2 and 9, into the joint cavity. In conclusion, laser therapy was effective in reducing inflammation to sites of injury and inhibit activation of proteases (gelatinase) suggesting less degradation of collagen tissue in experimental model of acute arthritis.

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Title: Protective effect of low-level laser therapy (LLLT) on acute zymosan-induced arthritis
Authors: Fernando Pereira Carlos
Marcelo de Paula Alves da Silva
Eliadna de Lemos Vasconcelos Silva Melo
Maricilia Silva Costa
Stella Regina Zamuner
Publication date: 01-03-2014
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 2/2014
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-013-1413-3

At a glance: The STEP trials

Springer Medicine

Protective effect of low-level laser therapy (LLLT) on acute zymosan-induced arthritis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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