Top

Published in:

01-03-2012 | Original Article

Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation

Authors: Marco Mozzati, Germana Martinasso, Nadia Cocero, Renato Pol, Marina Maggiora, Giuliana Muzio, Rosa Angela Canuto

Published in: Lasers in Medical Science | Issue 2/2012

Abstract

Alveolar healing following tooth extraction is a complex repair process involving different tissues, including epithelium and bone. This research aimed to study the effect of laser therapy on alveolar healing process in patients waiting for liver transplantation, evaluating some inflammation, osteogenesis, and clinical parameters. Twelve patients with hepatic failure waiting for liver transplantation, with indications to bilateral extraction, entered the split-mouth study. One post-extractive defect was treated with laser while the other was left without treatment. Specimens of soft tissues were removed from around the tooth before extraction and after 7 days. Superpulsed laser irradiation prevented IL-1β increase and induced IL-6, IL-10, and collagen III increase at 7 days in comparison to their level before extraction, whereas the other parameters were unmodified. Moreover, the epithelial regeneration evidenced a positive result of laser therapy, and the patients reported less pain in the site treated with laser. In conclusion, laser therapy appears to be the treatment of choice for patients due to its clinical efficacy, safety, good tolerance, and its ability to prevent inflammation.

Boyne PJ (1966) Osseous repair of the postextraction alveolus in man. Oral Surg Oral Med Oral Pathol 21:805–813PubMedCrossRef

Ahn JJ, Shin HI (2008) Bone tissue formation in extraction sockets from sites with advanced periodontal disease: a histomorphometric study in humans. Int J Oral Maxillofac Implant 23:1133–1138

Douglas LR, Douglas JB, Sieck JO, Smith PJ (1998) Oral management of the patients with end-stage liver disease and liver transplant patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:55–64PubMedCrossRef

Chiapasco M, Casentini P, Zaniboni M (2009) Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants 24:237–259PubMed

Obradović RR, Kesić LG, Pesevska S (2009) Influence of low-level laser therapy on biomaterial osseointegration: a mini-review. Lasers Med Sci 24:447–451PubMedCrossRef

Walsh LJ (2003) The current status of laser applications in dentistry. Aust Dent J 48:146–155PubMedCrossRef

Qadri T, Miranda L, Tunér J, Gustafsson A (2005) The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation. J Clin Periodontol 32:714–719PubMedCrossRef

Chukwuneke F, Onyejiaka N (2007) Management of postoperative morbidity after third molar surgery: a review of the literature. Niger J Med 16:107–112PubMed

Sun G, Tunér J (2004) Low-level laser therapy in dentistry. Dent Clin North Am 48:1061–1076PubMedCrossRef

10.

Saracino S, Mozzati M, Martinasso G, Pol R, Canuto RA, Muzio G (2009) Superpulsed laser irradiation increases osteoblast activity via modulation of bone morphogenetic factors. Lasers Surg Med 41:298–304PubMedCrossRef

11.

Peplow PV, Chung TY, Baxter GD (2009) Laser photobiomodulation of wound healing: a review of experimental studies in mouse and rat animal models. Photomed Laser Surg [Epub ahead of print]

12.

Gonzaga Ribeiro MA, Cavalcanti de Albuquerque RL, Santos Barreto AL, Moreno de Oliveira VG, Santos TB, Freitas Dantas CD (2009) Morphological analysis of second-intention wound healing in rats submitted to 16 J/cm² lambda 660-nm laser irradiation. Indian J Dent Res 20:390–396PubMed

13.

Medeiros JL, Nicolau RA, Nicola EM, Dos Santos JN, Pinheiro AL (2009) Healing of surgical wounds made with lambda 970-nm diode laser associated or not with laser phototherapy (lambda 655 nm) or polarized light (lambda 400-2,000 nm). Photomed Laser Surg [Epub ahead of print]

14.

Schwarz F, Aoki A, Sculean A, Becker J (2000) The impact of laser application on periodontal and peri-implant wound healing. Periodontol 51:79–108CrossRef

15.

Delaleu N, Bickel M (2000) Interleukin-1β and interleukin-18: regulation and activity in local inflammation. Periodontol 35:42–52CrossRef

16.

Orozco A, Gemmel E, Bickel M, Seymour GJ (2006) Interleukin 1β, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. Oral Microb Immunol 21:256–260CrossRef

17.

Schierano G, Pejrone G, Roana J, Scalas D, Allizond V, Martinasso G et al (2010) A split-mouth study on microbiological profile in clinical healthy teeth and implants related to key inflammatory mediators. Int J Immunopathol Pharmacol 23:279–288PubMed

18.

Schierano G, Pejrone G, Brusco P, Trombetta A, Martinasso G, Preti G et al (2008) TNF-α, TGF-β2 and Il-1β levels in gingival and peri-implant crevicular fluid before and after de novo plaque accumulation. J Clin Periodontol 35:532–538PubMedCrossRef

19.

Noguchi K, Ishikawa I (2000) The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease. Periodontol 43:85–101CrossRef

20.

Goutoudi P, Diza E, Arvantidou M (2004) Effect of periodontal therapy on crevicular fluid interleukin-1β and interleukin-10 levels in chronic periodontitis. J Dent 32:511–520PubMedCrossRef

21.

Lee YM, Fujikado N, Manaka H, Yasuda H, Iwakura Y (2010) IL-1 plays an important role in the bone metabolism under physiological conditions. Int Immunol 22:805–816PubMedCrossRef

22.

Delima AJ, Oates T, Assuma R, Schwartz Z, Cochran D, Amar S et al (2001) Soluble antagonists to interleukin-1 (IL1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. J Clin Periodontol 28:233–240PubMedCrossRef

23.

Malchow S, Thaiss W, Jänner N, Gewiese-Rabsch J, Garbers C, Yamamoto K, et al. (2010) Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 Signaling but not IL-6 trans-signaling. Biochim Biophys Acta [Epub ahead of print]

24.

Moore KW, de Waal MR, Coffman RL, O'Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683–765PubMedCrossRef

25.

Gál P, Mokrý M, Vidinský B, Kilík R, Depta F, Harakalová M et al (2009) Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and corticosteroid-treated rats. Lasers Med Sci 24:539–547PubMedCrossRef

26.

Gál P, Vidinský B, Toporcer T, Mokrý M, Mozes S, Longauer F et al (2006) Histological assessment of the effect of laser irradiation on skin wound healing in rats. Photomed Laser Surg 24:480–448PubMedCrossRef

27.

Ozcelik O, Cenk Haytac M, Kunin A, Seydaoglu G (2008) Improved wound healing by low-level laser irradiation after gingivectomy operations: a controlled clinical pilot study. J Clin Periodontol 35:250–254PubMedCrossRef

28.

Amorim JC, de Sousa GR, de Barros SL, Prates RA, Pinotti M, Ribeiro MS (2006) Clinical study of the gingiva healing after gingivectomy and low-level laser therapy. Photomed Laser Surg 24:588–594PubMedCrossRef

29.

Markovic A, Todorovic LJ (2007) Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. Int J Oral Maxillofac Surg 36:226–229PubMedCrossRef

30.

Antunes HS, de Azevedo AM, da Silva Bouzas LF, Adão CA, Pinheiro CT, Mayhe R et al (2007) Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial. Blood 109:2250–2255PubMedCrossRef

31.

Pourzarandian A, Watanabe H, Aoki A, Ichinose S, Sasaki KM, Nitta H et al (2004) Histological and TEM examination of early stages of bone healing after Er:YAG laser irradiation. Photomed Laser Surg 22:342–350PubMedCrossRef

32.

Polosukhin VV (2000) Ultrastructure of the blood and lymphatic capillaries of the respiratory tissue during inflammation and endobronchial laser therapy. Ultrastruct Pathol 24:183–189PubMedCrossRef

33.

Pires Oliveira DA, de Oliveira RF, Zangaro RA, Soares CP (2008) Evaluation of low-level laser therapy of osteoblastic cells. Photomed Laser Surg 26:401–404PubMedCrossRef

34.

Pinheiro AL, Gerbi ME (2006) Photoengineering of bone repair processes. Photomed Laser Surg 24:169–178PubMedCrossRef

35.

Maluf AP, Maluf RP, da Rocha Brito C, França FM, de Brito RB Jr (2010) Mechanical evaluation of the influence of low-level laser therapy in secondary stability of implants in mice shinbones. Lasers Med Sci [Epub ahead of print]

36.

Mozzati M, Martinasso G, Pol R, Polastri C, Cristiano A, Muzio G, et al (2010) The impact of PRGF on clinical and biological factors involved in healing processes following third molar extraction. J Biomed Mater Res A [Epub ahead of print]

37.

Opal SM, De Palo VA (2000) Anti-inflammatory cytokines. Chest 117:1162–1172PubMedCrossRef

38.

Werner S, Grose R (2003) Regulation of wound healing by growth factors and cytokines. Physiol Rev 83:835–870PubMed

39.

Chang HC, Bistrian B (1998) The role of cytokines in the catabolic consequences of infection and injury. J Parenter Enter Nutr 22:156–166CrossRef

Title: Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation
Authors: Marco Mozzati
Germana Martinasso
Nadia Cocero
Renato Pol
Marina Maggiora
Giuliana Muzio
Rosa Angela Canuto
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Lasers in Medical Science / Issue 2/2012
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-010-0880-z

At a glance: The STEP trials

Springer Medicine

Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2012

The effects of low-level laser irradiation on differentiation and proliferation of human bone marrow mesenchymal stem cells into neurons and osteoblasts—an in vitro study

Effects of different setting of diode laser on the mRNA expression of growth factors and type I collagen of human gingival fibroblasts

Porcelain conditioning with Nd:YAG and Er:YAG laser for bracket bonding in orthodontics

Effects of tetracycline hydrochloride on measurements with the laser fluorescence device DIAGNOdent: in vitro and in vivo studies

Influence of dental materials used for sealing caries lesions on laser fluorescence measurements

Functional and morphometric differences between the early and delayed use of phototherapy in crushed median nerves of rats