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Published in: Lasers in Medical Science 1/2010

01-01-2010 | Review Article

Fractional photothermolysis—an update

Authors: Inja Bogdan Allemann, Joely Kaufman

Published in: Lasers in Medical Science | Issue 1/2010

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Abstract

The novel concept of non-ablative fractional photothermolysis was introduced to the market in 2003 as an answer to the need for effective, yet low risk, resurfacing techniques. Unlike conventional ablative and non-ablative lasers, fractional ablative and non-ablative photothermolysis treats only a fraction of the skin, leaving up to a maximum of 95% of the skin uninvolved. The undamaged surrounding tissue allows for a reservoir of viable tissue, permitting rapid epidermal repair. Non-ablative fractional photothermolysis is currently approved by the US Food and Drug Administration (FDA) for the treatment of pigmented lesions, periorbital rhytides, skin resurfacing, melasma and soft tissue coagulation, acne and surgical scars, and actinic keratoses. However, its off-label use is clearly more extended. In 2007 the concept was further developed, and ablative fractional photothermolysis was introduced, using an erbium yttrium aluminium garnet (Er:YAG) or carbon dioxide laser. These devices are FDA cleared to treat wrinkles, rhytides, furrows, fine lines, textural irregularities, pigmented lesions and vascular dyschromia. In this review we discuss the two concepts, their technical details and clinical indications, and we describe the current literature available.
Literature
1.
go back to reference Huzaira M, Anderson RR, Sink K, Manstein D (2003) Intradermal focusing of near-infrared optical pulses: a new approach for non-ablative laser therapy. Lasers Surg Med 32(Suppl 15):17–38 Huzaira M, Anderson RR, Sink K, Manstein D (2003) Intradermal focusing of near-infrared optical pulses: a new approach for non-ablative laser therapy. Lasers Surg Med 32(Suppl 15):17–38
2.
go back to reference Manstein D, Herron GS, Sink RK et al (2004) Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 34:426–438CrossRefPubMed Manstein D, Herron GS, Sink RK et al (2004) Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 34:426–438CrossRefPubMed
3.
go back to reference Khan MH, Sink RK, Manstein D, Eimerl D, Anderson RR (2005) Intradermally focused infrared laser pulses: thermal effects at defined tissue depths. Lasers Surg Med 36:270–280CrossRefPubMed Khan MH, Sink RK, Manstein D, Eimerl D, Anderson RR (2005) Intradermally focused infrared laser pulses: thermal effects at defined tissue depths. Lasers Surg Med 36:270–280CrossRefPubMed
4.
go back to reference Laubach HJ, Tannous Z, Anderson RR, Manstein D (2006) Skin responses to fractional photothermolysis. Lasers Surg Med 38:142–149CrossRefPubMed Laubach HJ, Tannous Z, Anderson RR, Manstein D (2006) Skin responses to fractional photothermolysis. Lasers Surg Med 38:142–149CrossRefPubMed
5.
go back to reference Hantash BM, Bedi VP, Chan KF, Zachary CB (2007) Ex vivo histological characterization of a novel ablative fractional resurfacing device. Lasers Surg Med 39:87–95CrossRefPubMed Hantash BM, Bedi VP, Chan KF, Zachary CB (2007) Ex vivo histological characterization of a novel ablative fractional resurfacing device. Lasers Surg Med 39:87–95CrossRefPubMed
6.
go back to reference Trelles MA, Mordon S, Velez M, Urdiales F, Levy JL (2009) Results of fractional ablative facial skin resurfacing with the erbium:yttrium-aluminium-garnet laser 1 week and 2 months after one single treatment in 30 patients. Lasers Med Sci 24:186–194 Trelles MA, Mordon S, Velez M, Urdiales F, Levy JL (2009) Results of fractional ablative facial skin resurfacing with the erbium:yttrium-aluminium-garnet laser 1 week and 2 months after one single treatment in 30 patients. Lasers Med Sci 24:186–194
7.
go back to reference Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220:524–527CrossRefPubMed Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220:524–527CrossRefPubMed
8.
go back to reference Bodendorf MO, Grunewald S, Wetzig T, Simon JC, Paasch U (2009) Fractional laser skin therapy. J Dtsch Dermatol Ges 7:301–308 Bodendorf MO, Grunewald S, Wetzig T, Simon JC, Paasch U (2009) Fractional laser skin therapy. J Dtsch Dermatol Ges 7:301–308
9.
go back to reference Tan KL, Kurniawati C, Gold MH (2008) Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device. J Drugs Dermatol 7:774–777PubMed Tan KL, Kurniawati C, Gold MH (2008) Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device. J Drugs Dermatol 7:774–777PubMed
10.
go back to reference Kono T, Chan HH, Groff WF, Manstein D, Sakurai H, Takeuchi M, Yamaki T, Soejima K, Nozaki M (2007) Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. Lasers Surg Med 39:311–314CrossRefPubMed Kono T, Chan HH, Groff WF, Manstein D, Sakurai H, Takeuchi M, Yamaki T, Soejima K, Nozaki M (2007) Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. Lasers Surg Med 39:311–314CrossRefPubMed
11.
go back to reference Avram MM, Tope WD, Yu T, Szachowicz E, Nelson JS (2009) Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing. Lasers Surg Med 41:185–188CrossRefPubMed Avram MM, Tope WD, Yu T, Szachowicz E, Nelson JS (2009) Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing. Lasers Surg Med 41:185–188CrossRefPubMed
12.
go back to reference Fife DJ, Fitzpatrick RE, Zachary CB (2009) Complications of fractional CO2 laser resurfacing: four cases. Lasers Surg Med 41:179–184CrossRefPubMed Fife DJ, Fitzpatrick RE, Zachary CB (2009) Complications of fractional CO2 laser resurfacing: four cases. Lasers Surg Med 41:179–184CrossRefPubMed
14.
go back to reference Fisher GH, Geronemus RG (2005) Short-term side effects of fractional photothermolysis. Dermatol Surg 31:1245–1249PubMed Fisher GH, Geronemus RG (2005) Short-term side effects of fractional photothermolysis. Dermatol Surg 31:1245–1249PubMed
15.
go back to reference Graber EM, Tanzi EL, Alster TS (2008) Side effects and complications of fractional laser photothermolysis: experience with 961 treatments. Dermatol Surg 34:301–305CrossRefPubMed Graber EM, Tanzi EL, Alster TS (2008) Side effects and complications of fractional laser photothermolysis: experience with 961 treatments. Dermatol Surg 34:301–305CrossRefPubMed
16.
go back to reference Wanner M, Tanzi EL, Alster TS (2007) Fractional photothermolysis: treatment of facial and nonfacial cutaneous photodamage with a 1,550-nm erbium-doped fiber laser. Dermatol Surg 33:23–28CrossRefPubMed Wanner M, Tanzi EL, Alster TS (2007) Fractional photothermolysis: treatment of facial and nonfacial cutaneous photodamage with a 1,550-nm erbium-doped fiber laser. Dermatol Surg 33:23–28CrossRefPubMed
17.
go back to reference Jih MH, Goldberg LH, Kimyai-Asadi A (2008) Fractional photothermolysis for photoaging of hands. Dermatol Surg 34:73–78PubMedCrossRef Jih MH, Goldberg LH, Kimyai-Asadi A (2008) Fractional photothermolysis for photoaging of hands. Dermatol Surg 34:73–78PubMedCrossRef
18.
go back to reference Geronemus RG (2006) Fractional photothermolysis: current and future applications. Lasers Surg Med 38:169–176CrossRefPubMed Geronemus RG (2006) Fractional photothermolysis: current and future applications. Lasers Surg Med 38:169–176CrossRefPubMed
19.
go back to reference Tannous ZS, Astner S (2005) Utilizing fractional resurfacing in the treatment of therapy-resistant melasma. J Cosmet Laser Ther 7:39–43CrossRefPubMed Tannous ZS, Astner S (2005) Utilizing fractional resurfacing in the treatment of therapy-resistant melasma. J Cosmet Laser Ther 7:39–43CrossRefPubMed
20.
go back to reference Rokhsar CK, Fitzpatrick RE (2005) The treatment of melasma with fractional photothermolysis: a pilot study. Dermatol Surg 31:1645–1650PubMed Rokhsar CK, Fitzpatrick RE (2005) The treatment of melasma with fractional photothermolysis: a pilot study. Dermatol Surg 31:1645–1650PubMed
21.
go back to reference Naito SK (2007) Fractional photothermolysis treatment for resistant melasma in Chinese females. J Cosmet Laser Ther 9:161–163CrossRefPubMed Naito SK (2007) Fractional photothermolysis treatment for resistant melasma in Chinese females. J Cosmet Laser Ther 9:161–163CrossRefPubMed
22.
go back to reference Goldberg DJ, Berlin AL, Phelps R (2008) Histologic and ultrastructural analysis of melasma after fractional resurfacing. Lasers Surg Med 40:134–138CrossRefPubMed Goldberg DJ, Berlin AL, Phelps R (2008) Histologic and ultrastructural analysis of melasma after fractional resurfacing. Lasers Surg Med 40:134–138CrossRefPubMed
23.
go back to reference Hasegawa T, Matsukura T, Mizuno Y, Suga Y, Ogawa H, Ikeda S (2006) Clinical trial of a laser device called fractional photothermolysis system for acne scars. J Dermatol 33:623–627CrossRefPubMed Hasegawa T, Matsukura T, Mizuno Y, Suga Y, Ogawa H, Ikeda S (2006) Clinical trial of a laser device called fractional photothermolysis system for acne scars. J Dermatol 33:623–627CrossRefPubMed
24.
go back to reference Alster TS, Tanzi EL, Lazarus M (2007) The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatol Surg 33:295–299CrossRefPubMed Alster TS, Tanzi EL, Lazarus M (2007) The use of fractional laser photothermolysis for the treatment of atrophic scars. Dermatol Surg 33:295–299CrossRefPubMed
25.
go back to reference Lee HS, Lee JH, Ahn GY, Lee DH, Shin JW, Kim DH, Chung JH (2008) Fractional photothermolysis for the treatment of acne scars: a report of 27 Korean patients. J Dermatolog Treat 19:45–49CrossRefPubMed Lee HS, Lee JH, Ahn GY, Lee DH, Shin JW, Kim DH, Chung JH (2008) Fractional photothermolysis for the treatment of acne scars: a report of 27 Korean patients. J Dermatolog Treat 19:45–49CrossRefPubMed
26.
go back to reference Glaich AS, Rahman Z, Goldberg LH, Friedman PM (2007) Fractional resurfacing for the treatment of hypopigmented scars: a pilot study. Dermatol Surg 33:289–294CrossRefPubMed Glaich AS, Rahman Z, Goldberg LH, Friedman PM (2007) Fractional resurfacing for the treatment of hypopigmented scars: a pilot study. Dermatol Surg 33:289–294CrossRefPubMed
27.
go back to reference Behroozan DS, Goldberg LH, Dai T, Geronemus RG, Friedman PM (2006) Fractional photothermolysis for the treatment of surgical scars: a case report. J Cosmet Laser Ther 8:35–38CrossRefPubMed Behroozan DS, Goldberg LH, Dai T, Geronemus RG, Friedman PM (2006) Fractional photothermolysis for the treatment of surgical scars: a case report. J Cosmet Laser Ther 8:35–38CrossRefPubMed
28.
go back to reference Glaich AS, Goldberg LH, Dai T, Friedman PM (2007) Fractional photothermolysis for the treatment of telangiectatic matting: a case report. J Cosmet Laser Ther 9:101–103CrossRefPubMed Glaich AS, Goldberg LH, Dai T, Friedman PM (2007) Fractional photothermolysis for the treatment of telangiectatic matting: a case report. J Cosmet Laser Ther 9:101–103CrossRefPubMed
29.
go back to reference Glaich AS, Goldberg LH, Dai T, Kunishige JH, Friedman PM (2007) Fractional resurfacing: a new therapeutic modality for Becker’s nevus. Arch Dermatol 143:1488–1490CrossRefPubMed Glaich AS, Goldberg LH, Dai T, Kunishige JH, Friedman PM (2007) Fractional resurfacing: a new therapeutic modality for Becker’s nevus. Arch Dermatol 143:1488–1490CrossRefPubMed
30.
go back to reference Kouba DJ, Fincher EF, Moy RL (2008) Nevus of Ota successfully treated by fractional photothermolysis using a fractionated 1440-nm Nd:YAG laser. Arch Dermatol 144:156–158CrossRefPubMed Kouba DJ, Fincher EF, Moy RL (2008) Nevus of Ota successfully treated by fractional photothermolysis using a fractionated 1440-nm Nd:YAG laser. Arch Dermatol 144:156–158CrossRefPubMed
31.
go back to reference Kim BJ, Lee DH, Kim MN, Song KY, Cho WI, Lee CK, Kim JY, Kwon OS (2008) Fractional photothermolysis for the treatment of striae distensae in Asian skin. Am J Clin Dermatol 9:33–37CrossRefPubMed Kim BJ, Lee DH, Kim MN, Song KY, Cho WI, Lee CK, Kim JY, Kwon OS (2008) Fractional photothermolysis for the treatment of striae distensae in Asian skin. Am J Clin Dermatol 9:33–37CrossRefPubMed
32.
go back to reference Behroozan DS, Goldberg LH, Glaich AS, Dai T, Friedman PM (2006) Fractional photothermolysis for treatment of poikiloderma of civatte. Dermatol Surg 32:298–301CrossRefPubMed Behroozan DS, Goldberg LH, Glaich AS, Dai T, Friedman PM (2006) Fractional photothermolysis for treatment of poikiloderma of civatte. Dermatol Surg 32:298–301CrossRefPubMed
33.
go back to reference Blankenship CM, Alster TS (2008) Fractional photothermolysis of residual hemangioma. Dermatol Surg 34:1112–1114CrossRefPubMed Blankenship CM, Alster TS (2008) Fractional photothermolysis of residual hemangioma. Dermatol Surg 34:1112–1114CrossRefPubMed
34.
go back to reference Beer K, Waibel J (2007) Botulinum toxin type A enhances the outcome of fractional resurfacing of the cheek. J Drugs Dermatol 6:1151–1152PubMed Beer K, Waibel J (2007) Botulinum toxin type A enhances the outcome of fractional resurfacing of the cheek. J Drugs Dermatol 6:1151–1152PubMed
35.
go back to reference Ruiz-Rodriguez R, López L, Candelas D, Zelickson B (2007) Enhanced efficacy of photodynamic therapy after fractional resurfacing: fractional photodynamic rejuvenation. J Drugs Dermatol 6:818–820PubMed Ruiz-Rodriguez R, López L, Candelas D, Zelickson B (2007) Enhanced efficacy of photodynamic therapy after fractional resurfacing: fractional photodynamic rejuvenation. J Drugs Dermatol 6:818–820PubMed
36.
go back to reference Pandolfino T, Laubach HJ, Gaguon D, Manstein D (2006) CO2 Laser induced ablative micropatterns in skin. Lasers Surg Med 18:82 Pandolfino T, Laubach HJ, Gaguon D, Manstein D (2006) CO2 Laser induced ablative micropatterns in skin. Lasers Surg Med 18:82
37.
go back to reference Clementoni MT, Gilardino P, Muti GF, Beretta D, Schianchi R (2007) Non-sequential fractional ultrapulsed CO2 resurfacing of photoaged facial skin: preliminary clinical report. J Cosmet Laser Ther 9:218–225CrossRefPubMed Clementoni MT, Gilardino P, Muti GF, Beretta D, Schianchi R (2007) Non-sequential fractional ultrapulsed CO2 resurfacing of photoaged facial skin: preliminary clinical report. J Cosmet Laser Ther 9:218–225CrossRefPubMed
38.
go back to reference Gold MH (2007) Fractional technology: a review and clinical approaches. J Drugs Dermatol 6:849–852PubMed Gold MH (2007) Fractional technology: a review and clinical approaches. J Drugs Dermatol 6:849–852PubMed
39.
go back to reference Dierickx CC, Khatri KA, Tannous ZS, Childs JJ, Cohen RH, Erofeev A, Tabatadze D, Yaroslavsky IV, Altshuler GB (2008) Micro-fractional ablative skin resurfacing with two novel erbium laser systems. Lasers Surg Med 40:113–123CrossRefPubMed Dierickx CC, Khatri KA, Tannous ZS, Childs JJ, Cohen RH, Erofeev A, Tabatadze D, Yaroslavsky IV, Altshuler GB (2008) Micro-fractional ablative skin resurfacing with two novel erbium laser systems. Lasers Surg Med 40:113–123CrossRefPubMed
40.
go back to reference Lapidoth M, Yagima Odo ME, Odo LM (2008) Novel use of erbium:YAG (2, 940-nm) laser for fractional ablative photothermolysis in the treatment of photodamaged facial skin: a pilot study. Dermatol Surg 34:1048–1053CrossRefPubMed Lapidoth M, Yagima Odo ME, Odo LM (2008) Novel use of erbium:YAG (2, 940-nm) laser for fractional ablative photothermolysis in the treatment of photodamaged facial skin: a pilot study. Dermatol Surg 34:1048–1053CrossRefPubMed
41.
go back to reference Berlin AL, Hussain M, Phelps R, Goldberg DJ (2009) A prospective study of fractional scanned nonsequential carbon dioxide laser resurfacing: a clinical and histopathologic evaluation. Dermatol Surg 35:222–228CrossRefPubMed Berlin AL, Hussain M, Phelps R, Goldberg DJ (2009) A prospective study of fractional scanned nonsequential carbon dioxide laser resurfacing: a clinical and histopathologic evaluation. Dermatol Surg 35:222–228CrossRefPubMed
42.
go back to reference Chapas AM, Brightman L, Sukal S, Hale E, Daniel D, Bernstein LJ, Geronemus RG (2008) Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. Lasers Surg Med 40:381–386CrossRefPubMed Chapas AM, Brightman L, Sukal S, Hale E, Daniel D, Bernstein LJ, Geronemus RG (2008) Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. Lasers Surg Med 40:381–386CrossRefPubMed
43.
go back to reference Kim S, Cho KH (2009) Clinical trial of dual treatment with an ablative fractional laser and a nonablative laser for the treatment of acne scars in Asian patients. Dermatol Surg 35:1089–1098CrossRefPubMed Kim S, Cho KH (2009) Clinical trial of dual treatment with an ablative fractional laser and a nonablative laser for the treatment of acne scars in Asian patients. Dermatol Surg 35:1089–1098CrossRefPubMed
44.
go back to reference Waibel J, Beer K (2009) Ablative fractional laser resurfacing for the treatment of a third-degree burn. J Drugs Dermatol 8:294–297PubMed Waibel J, Beer K (2009) Ablative fractional laser resurfacing for the treatment of a third-degree burn. J Drugs Dermatol 8:294–297PubMed
45.
go back to reference Hædersdal M (2009) Fractional ablative CO(2) laser resurfacing improves a thermal burn scar. J Eur Acad Dermatol Venereol 4. Epub 2009 Mar 4 Hædersdal M (2009) Fractional ablative CO(2) laser resurfacing improves a thermal burn scar. J Eur Acad Dermatol Venereol 4. Epub 2009 Mar 4
Metadata
Title
Fractional photothermolysis—an update
Authors
Inja Bogdan Allemann
Joely Kaufman
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Lasers in Medical Science / Issue 1/2010
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-009-0734-8

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