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31-05-2022 | Venous Thrombosis | Review Article

Late epileptic seizures following cerebral venous thrombosis: a systematic review and meta-analysis

Authors: Sara Gasparini, Sabrina Neri, Francesco Brigo, Vittoria Cianci, Anna Mammì, Angelo Pascarella, Lucia Manzo, Paolo Benna, Pasquale Striano, Tommaso Martino, Michele Romoli, Lorenzo Muccioli, Annacarmen Nilo, Mariarosaria Valente, Claudia Cagnetti, Angelo Labate, Antonio Gambardella, Francesco Pisani, Sara Casciato, Giancarlo Di Gennaro, Vincenzo Belcastro, Umberto Aguglia, Edoardo Ferlazzo, Epilepsy Study Group of the Italian Neurological Society

Published in: Neurological Sciences | Issue 9/2022

Abstract

Background

Identifying late epileptic seizures (LS) following cerebral venous thrombosis (CVT) can be useful for prognosis and management. We systematically reviewed the literature to identify risk factors for LS due to CVT.

Methods

We systematically searched PubMed, Scholar, and Scopus databases (May 2021) to identify studies reporting data on prevalence and risk factors for CVT-LS. The methodological quality was assessed with the Ottawa-Newcastle Scale. The risk of developing CVT-LS was summarized in meta-analyses and expressed as odds ratio (OR) and corresponding 95% confidence intervals (CIs) using random-effects models.

Results

Out of the 332 records retrieved, four studies were eventually included with a total of 1309 patients with CVT and 142 (11%) with CVT-LS. The most relevant predictors of CVT-LS were symptomatic seizures (OR 5.66, 95% CI 3.83–8.35), stupor/coma (OR 6.81, 95% CI 1.18–39.20), focal neurologic signs (OR 6.81, 95% CI 1.18–39.2), hemorrhagic component (OR 3.52, 95% CI 2.45–5.06), and superior sagittal sinus involvement (OR 1.52, 95% CI 1.04–2.21).

Conclusion

There are several risk factors for CVT-LS that should be considered in clinical practice. Further high-quality studies are warranted to develop predictive models for individualized risk stratification and prediction of CVT-LS.

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Title: Late epileptic seizures following cerebral venous thrombosis: a systematic review and meta-analysis
Authors: Sara Gasparini
Sabrina Neri
Francesco Brigo
Vittoria Cianci
Anna Mammì
Angelo Pascarella
Lucia Manzo
Paolo Benna
Pasquale Striano
Tommaso Martino
Michele Romoli
Lorenzo Muccioli
Annacarmen Nilo
Mariarosaria Valente
Claudia Cagnetti
Angelo Labate
Antonio Gambardella
Francesco Pisani
Sara Casciato
Giancarlo Di Gennaro
Vincenzo Belcastro
Umberto Aguglia
Edoardo Ferlazzo
Epilepsy Study Group of the Italian Neurological Society
Publication date: 31-05-2022
Publisher: Springer International Publishing
Keywords: Venous Thrombosis
Epilepsy
Venous Thrombosis
Coma
Epileptic Seizure
Published in: Neurological Sciences / Issue 9/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06148-y

At a glance: The STEP trials

Springer Medicine

Late epileptic seizures following cerebral venous thrombosis: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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