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Neurological Sciences

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02-03-2022 | Autism Spectrum Disorder | Original Article

Sensitivity and specificity of pupillary light reflex measures for ASD using monocular pupillometry

Authors: Georgina T. F. Lynch, Stephen M. James, Teresa A. Cardon, Sterling M. McPherson

Published in: Neurological Sciences | Issue 7/2022

Abstract

Introduction

Automated hand-held pupillometry demonstrates precision accuracy, offering promise for augmenting ASD screening.

Methods

Monocular pupillometry was examined in children and adolescents (36 ASD; 24 TD). Multiple logistic regression and receiver operating characteristic analysis assessed PLR metrics and diagnostic status.

Results

Constriction time (Ct₁) (ASD: M = 0.69, SD = 0.21; TD: M = 0.82, SD = 0.18; t(58 = 2.37; p = 0.02) and return to baseline (RTB T75) (ASD: M = 2.93, SD = 1.21; TD: M = 2.32, SD = 1.08; t(58) = − 2.03; p = 0.04) predicted ASD (β = − 1.31, OR = 0.27; RTB T75, β = 0.156, OR = 1.162). Sensitivity = 74.8%, when RTB ≥ 1.83 s and 69.4% when Ct₁ = 0.785 s.

Conclusion

Findings suggest monocular pupillometry captures differences detecting ASD.

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Title: Sensitivity and specificity of pupillary light reflex measures for ASD using monocular pupillometry
Authors: Georgina T. F. Lynch
Stephen M. James
Teresa A. Cardon
Sterling M. McPherson
Publication date: 02-03-2022
Publisher: Springer International Publishing
Keyword: Autism Spectrum Disorder
Published in: Neurological Sciences / Issue 7/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05976-2

At a glance: The STEP trials

Springer Medicine

Sensitivity and specificity of pupillary light reflex measures for ASD using monocular pupillometry

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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