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01-07-2021 | Tremor | Original Article

Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson’s disease

Authors: Juan Wang, Yalian Shen, Juan Peng, Anran Wang, Xiaolin Wu, Xiaocui Chen, Jinjin Liu, Min Wei, Dezhi Zou, Yu Han, Oumei Cheng

Published in: Neurological Sciences | Issue 7/2021

Abstract

Background

Patients with akinetic-rigid Parkinson’s disease (AR-PD) are more prone to cognitive decline and depressive symptoms than tremor-dominant PD (TD-PD) patients. The right fronto-insular cortex (rFIC), as a key node of salience network, plays a critical role in the switching between central executive network and default mode network. In this study, we explored the functional connectivity mode of rFIC with triple-brain networks, namely default mode network, salience network, and central executive network, in two motor subtypes of PD.

Methods

We recruited 44 PD patients (including the TD-PD group and AR-PD group) and 18 age-matched healthy controls (HCs). We performed functional connectivity (FC) analysis of resting-state functional MRI.

Results

Compared with TD-PD, decreased FC were found in the right insular cortex and bilateral anterior cingulate gyrus in AR-PD. Compared with HCs, decreased FC in the bilateral insula, the anterior cingulate gyrus, the precentral gyrus, and the right medial frontal gyrus were found; therein, the FC value of rFIC-precentral gyrus was positively correlated with the Unified Parkinson’s Disease Rating Scale-II score in AR-PD (p = 0.0482, r = 0.4162). While TD-PD showed decreased FC in the left insula as well as bilateral anterior cingulate gyrus when compared with HCs, and the FC value of the rFIC-left insula was positively correlated with its Hamilton Depression Rating Scale score (p = 0.02, r = 0.50).

Conclusion

The functional connectivity mode of rFIC in AR-PD differed from that in TD-PD. The decreased rFIC FC with the other nodes of salience network might be a potential indicator for AR-PD patients prone to develop cognitive decline and depressive symptoms.

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Title: Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson’s disease
Authors: Juan Wang
Yalian Shen
Juan Peng
Anran Wang
Xiaolin Wu
Xiaocui Chen
Jinjin Liu
Min Wei
Dezhi Zou
Yu Han
Oumei Cheng
Publication date: 01-07-2021
Publisher: Springer International Publishing
Keywords: Tremor
Parkinson's Disease
Published in: Neurological Sciences / Issue 7/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04917-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson’s disease

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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