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Neurological Sciences

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Open Access 01-01-2021 | Deep Brain Stimulation | Original Article

Frameless stereotaxy in subthalamic deep brain stimulation: 3-year clinical outcome

Authors: Carla Piano, Francesco Bove, Delia Mulas, Anna Rita Bentivoglio, Beatrice Cioni, Tommaso Tufo

Published in: Neurological Sciences | Issue 1/2021

Abstract

Background

In most centers, the surgery of deep brain stimulation (DBS) is performed using a stereotactic frame. Compared with frame-based technique, frameless stereotaxy reduces the duration of surgical procedure and patient’s discomfort, with lead placing accuracy equivalent after the learning curve. Although several studies have investigated the targeting accuracy of this technique, only a few studies reported clinical outcomes, with data of short-term follow-up.

Objective

To assess clinical efficacy and safety of frameless bilateral subthalamic nucleus (STN) DBS in Parkinson’s disease (PD) patients at 1- and 3-year follow-up.

Methods

Consecutive PD patients who underwent bilateral STN-DBS with a manual adjustable frameless system were included in the study. The data were collected retrospectively.

Results

Eighteen PD patients underwent bilateral STN-DBS implant and were included in the study. All patients completed 1-year observation and ten of them completed 3-year observation. At 1-year follow-up, motor efficacy of STN stimulation in off-med condition was of 30.1% (P = 0.003) and at 3-year follow-up was of 36.3%, compared with off-stim condition at 3-year follow-up (P = 0.005). Dopaminergic drugs were significantly reduced by 31.2% 1 year after the intervention (P = 0.003) and 31.7% 3 years after the intervention (P = 0.04). No serious adverse events occurred during surgery.

Conclusions

Frameless stereotaxy is an effective and safe technique for DBS surgery at 1- and 3-year follow-up, with great advantages for patients’ discomfort during surgery.

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Title: Frameless stereotaxy in subthalamic deep brain stimulation: 3-year clinical outcome
Authors: Carla Piano
Francesco Bove
Delia Mulas
Anna Rita Bentivoglio
Beatrice Cioni
Tommaso Tufo
Publication date: 01-01-2021
Publisher: Springer International Publishing
Keywords: Deep Brain Stimulation
Parkinson's Disease
Published in: Neurological Sciences / Issue 1/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04561-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Frameless stereotaxy in subthalamic deep brain stimulation: 3-year clinical outcome

Abstract

Background

Objective

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusions

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