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Published in: Neurological Sciences 10/2020

01-10-2020 | Neuromyelitis Optica Spectrum Disease | Original Article

Different clinical characteristics of longitudinally extensive transverse myelitis with and without connective tissue disorders: a single-center retrospective study

Authors: Qiu-Xia Zhang, Chen-Na Huang, Lin-Jie Zhang, Ming Yi, Nan Wang, Shu-Min Jiang, Li-Sha Chou, Sheng-Hui Chang, Ting Li, Li Yang

Published in: Neurological Sciences | Issue 10/2020

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Abstract

Background and objective

Autoimmune longitudinal extensive transverse myelitis (LETM) is often combined with connective tissue disorders (CTD). The purpose of this study was to compare the clinical characteristics of autoimmune LETM with and without CTD.

Methods

Ninety-two patients diagnosed with autoimmune LETM were enrolled from our clinical database and divided into two groups depending on whether they had a concomitant diagnosis of CTD. Differences in clinical, serological, and imaging characteristics between the two groups were evaluated and compared.

Results

Fifty-nine LETM patients without CTD and 33 LETM patients with CTD were included. LETM patients with CTD had higher Kurtzke Expanded Disability Status Scale at nadir and more severe sensory dysfunction (p < 0.05) than those without CTD. It was also found that LETM patients with CTD, compared with those without CTD, had elevated levels of immune inflammation markers such as IgG, IgA, and globulins (p < 0.05). These abovementioned characteristics were more prominent in patients with aquaporin-4 antibodies (AQP4-ab) than in those without them. In addition, the most common type of CTD in LETM was Sjögren syndrome (SS), which was usually diagnosed at the time of LETM or later.

Conclusion

LETM patients with CTD, especially those with AQP4-ab, had greater sensory dysfunction and higher levels of inflammatory markers than did LETM patients without CTD. Multicenter cooperation and long-term follow-up are necessary to further study the inherent implications and prognosis of the disease.
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Metadata
Title
Different clinical characteristics of longitudinally extensive transverse myelitis with and without connective tissue disorders: a single-center retrospective study
Authors
Qiu-Xia Zhang
Chen-Na Huang
Lin-Jie Zhang
Ming Yi
Nan Wang
Shu-Min Jiang
Li-Sha Chou
Sheng-Hui Chang
Ting Li
Li Yang
Publication date
01-10-2020
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 10/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04429-y

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