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Neurological Sciences

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01-09-2020 | Stroke | Original Article

Lymphocyte-to-monocyte ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke

Authors: Quhong Song, Ruosu Pan, Yuxi Jin, Yanan Wang, Yajun Cheng, Junfeng Liu, Bo Wu, Ming Liu

Published in: Neurological Sciences | Issue 9/2020

Abstract

Background

Hemorrhagic transformation (HT) is a common complication of acute ischemic stroke (AIS), and inflammation has been found to play an important role in the occurrence of HT. We aimed to investigate the impact of lymphocyte-to-monocyte ratio (LMR), a maker of inflammatory status, on HT in patients with AIS.

Methods

Consecutive AIS patients within 7 days from stroke onset were enrolled between January 2016 and October 2017. LMR was calculated according to lymphocyte and monocyte counts obtained within 24 h on admission. Patients were categorized into three groups according to LMR tertiles. HT was detected by follow-up computed tomography (CT) or magnetic resonance imaging (MRI) during hospitalization. The multivariate logistic analysis was used to evaluate the independent relationship between LMR and HT.

Results

A total of 1005 patients were finally included. HT was observed in 99 (9.9%) patients, with 51 (5.1%) hemorrhagic infarction (HI) and 48 (4.8%) parenchymal hematoma (PH). After adjustment for potential confounders, the odds ratio (OR) of HT was 0.523 (95% confidence interval [CI] 0.293–0.936, P = 0.029) for the highest LMR tertile compared with the lowest tertile. Multiple-adjusted spline regression model showed a nonlinear approximately L-shaped relationship between LMR levels and HT (P for nonlinear trend = 0.030). There was no significant association of baseline LMR with PH (OR 0.562, 95% CI 0.249–1.268, P = 0.165).

Conclusion

Lower LMR was independently related to higher risk of HT in patients with AIS. Admission LMR may be used as one of the predictors for HT. Further prospective multicenter studies are needed to validate our findings.

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Title: Lymphocyte-to-monocyte ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke
Authors: Quhong Song
Ruosu Pan
Yuxi Jin
Yanan Wang
Yajun Cheng
Junfeng Liu
Bo Wu
Ming Liu
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Neurological Sciences / Issue 9/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04355-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Lymphocyte-to-monocyte ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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