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Neurological Sciences

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01-08-2020 | Urinary Incontinence | Original Article

Association between ZNF184 and symptoms of Parkinson’s disease in southern Chinese

Authors: Bei Zhang, Can Cui, Hongxiang Yu, Gang Li

Published in: Neurological Sciences | Issue 8/2020

Abstract

Study objectives

The aim was to investigate the association between ZNF184 and symptoms of Parkinson’s disease (PD) in southern Chinese.

Methods

A total of 241 PD patients were recruited in this study. All patients were evaluated by Sniffin’ Sticks 16 (SS-16), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson’s disease Questionnaire (PDQ-39) and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

Results

There was association of rapid eye movement sleep behavior disorder (RBD) under additive, dominant and overdominant model (p 0.039, additive; p 0.028, dominant; p 0.044, overdominant). We also found the association of excessive daytime sleepiness under the dominant model, the association of urgent urination or urinary incontinence under the recessive model and the association of sensitive to hot under the overdominant model (excessive daytime sleepiness: p 0.032, dominant; p 0.038, dominant; urgent urination or urgent incontinence: p 0.027, recessive; sensitive to hot: p, 0.027, overdominant).

Conclusions

ZNF184 rs9468199 was associated with the presence of RBD, excessive daytime sleepiness, urgent urination or urgent incontinence and sensitive to hot.

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Title: Association between ZNF184 and symptoms of Parkinson’s disease in southern Chinese
Authors: Bei Zhang
Can Cui
Hongxiang Yu
Gang Li
Publication date: 01-08-2020
Publisher: Springer International Publishing
Keywords: Urinary Incontinence
Parkinson's Disease
Restless Legs Syndrome
Urinary Incontinence
Published in: Neurological Sciences / Issue 8/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04309-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Association between ZNF184 and symptoms of Parkinson’s disease in southern Chinese

Abstract

Study objectives

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Study objectives

Methods

Results

Conclusions

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