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01-06-2020 | Ultrasound | Original Article

Association between serum bilirubin and asymptomatic intracranial atherosclerosis: results from a population-based study

Authors: Kaiyi Zhong, Xiang Wang, Xiaotong Ma, Xiaokang Ji, Shaowei Sang, Sai Shao, Yuanyuan Zhao, Yuanyuan Xiang, Jifeng Li, Guangbin Wang, Ming Lv, Fuzhong Xue, Yifeng Du, Qinjian Sun

Published in: Neurological Sciences | Issue 6/2020

Abstract

Introduction

The effects of bilirubin on asymptomatic intracranial atherosclerosis (aICAS) remain uncertain.

Objectives

To investigate the association between bilirubin and aICAS in rural-dwelling Chinese people.

Methods

This population-based study included 2013 participants from the Kongcun Town Study, which aimed to investigate the prevalence of aICAS in people aged ≥ 40 years who were free of stroke and hepatic and gall disease history. Baseline data were collected via interviews, clinical examinations, and laboratory tests. Total bilirubin (Tbil), direct bilirubin (Dbil), and indirect bilirubin (Ibil) levels were divided into high-concentration group and low-concentration group, respectively. We diagnosed aICAS and moderate-to-severe aICAS (m-saICAS) (≥ 50% stenosis) by integrating transcranial Doppler ultrasound with magnetic resonance angiography. The association between bilirubin and aICAS, as well as m-saICAS, was analyzed using logistic regression.

Results

Of the 2013 participants, those in the high-concentration group of Tbil (odds ratio (OR), 0.50; 95% confidence interval (CI), 0.42–0.87), Dbil (OR 0.60, 95%CI 0.41–0.87), and Ibil (OR 0.67; 95%CI 0.47–0.97) had a lower risk of aICAS than those in the low-concentration group after adjusting all confounders. The high concentrations of Tbil, Dbil, and Ibil were also negatively associated with m-saICAS. After stratification according to age, Tbil, Dbil, and Ibil were significantly negatively associated with aICAS among participants aged ≥ 60 years.

Conclusion

Tbil, Dbil, and Ibil might be independent protective factors for aICAS and moderate-to-severe aICAS in rural-dwelling Chinese people, especially among older participants aged ≥ 60 years.

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Title: Association between serum bilirubin and asymptomatic intracranial atherosclerosis: results from a population-based study
Authors: Kaiyi Zhong
Xiang Wang
Xiaotong Ma
Xiaokang Ji
Shaowei Sang
Sai Shao
Yuanyuan Zhao
Yuanyuan Xiang
Jifeng Li
Guangbin Wang
Ming Lv
Fuzhong Xue
Yifeng Du
Qinjian Sun
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keywords: Ultrasound
Angiography
Arterial Occlusive Disease
Ultrasound
Published in: Neurological Sciences / Issue 6/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04268-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Association between serum bilirubin and asymptomatic intracranial atherosclerosis: results from a population-based study

Abstract

Introduction

Objectives

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Objectives

Methods

Results

Conclusion

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