Diffuse large B cell lymphoma mimics myasthenia gravis

Excerpt

Myasthenia gravis (MG) is the most common autoimmune disease affecting neuromuscular junction (NMJ) transmission [1]. It is characterized by muscle weakness that worsens with activity (fatigability). Ocular muscle weakness leading to ptosis and diplopia is the most common presenting feature. The diagnosis is usually suspected on clinical grounds and supported by specific neurophysiologic findings. The presence of serum acetylcholine receptor (AChR) antibodies confirms the diagnosis but is not mandatory. Chest CT scan is a part of the diagnostic work-up to evaluate the presence of thymoma. We present a case of a patient with asymmetrical ptosis, double vision, mediastinal tumour and neurophysiological abnormalities all due to disseminated B cell lymphoma. …