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01-10-2019 | Original Article

Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features

Authors: Maria Lieto, Alessandro Roca, Dario Bruzzese, Antonella Antenora, Girolamo Alfieri, Francesco Saccà, Marta Bellofatto, Leonilda Bilo, Stefano Barbato, Giuseppe De Michele, Alessandro Filla

Published in: Neurological Sciences | Issue 10/2019

Abstract

Sixty-six patients with possible or probable MSA (multiple system atrophy) cerebellar type, personally observed between 2006 and 2018 were retrospectively reviewed. The time point of data collection was January 1, 2019. Forty-nine patients lost independent walking after a median time of 5 years (95% C. I. 4–6). Thirty-two patients were confined to wheelchair after a median time of 7 years (95% C. I. 7–8). Twenty-seven patients were deceased after a median time of 9 years (95% C. I. 8–10). A later onset predicted an earlier loss of independent walking (HR 1.07; 95% C.I. 1.03–1.11; p = 0.001). Higher UMSARS score predicted shorter time to loss of independent walking (HR 1.04; 95% C.I. 1.02–1.06; p = 0.001) and to wheelchair (HR 1.03; 95% C.I. 1.01–1.06; p = 0.021). No predictor of time to death was found.

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Title: Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features
Authors: Maria Lieto
Alessandro Roca
Dario Bruzzese
Antonella Antenora
Girolamo Alfieri
Francesco Saccà
Marta Bellofatto
Leonilda Bilo
Stefano Barbato
Giuseppe De Michele
Alessandro Filla
Publication date: 01-10-2019
Publisher: Springer International Publishing
Published in: Neurological Sciences / Issue 10/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03948-7

At a glance: The STEP trials

Springer Medicine

Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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