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Neurological Sciences

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01-02-2019 | Original Article

Factors associated with freezing of gait in patients with Parkinson’s disease

Authors: Seong-Min Choi, Hyun-Jung Jung, Geum-Jin Yoon, Byeong C. Kim

Published in: Neurological Sciences | Issue 2/2019

Abstract

Background

Freezing of gait (FOG) is a common and debilitating problem in patients with Parkinson’s disease (PD). The aim of this study was to estimate the prevalence of FOG, and to identify factors that independently contribute to FOG in patients with PD.

Method

We included 157 PD patients. FOG was assessed using the FOG Questionnaire (FOG-Q). Patients with or without FOG were defined as item 3 in the FOG-Q.

Results

One hundred eleven (70.7%) out of 157 PD patients presented with FOG. Patients with FOG were older, had long disease duration, were taking higher doses of dopaminergic agents, and had higher motor and non-motor scores than those without FOG. Multivariate linear regression analysis showed that high modified Hoehn and Yahr (mHY) stage, Unified PD Rating Scale (UPDRS) part II score, and non-motor symptom assessment scale for PD (NMSS) total score were significant predictors of a high FOG-Q score. Patients with FOG had significantly higher scores for cardiovascular, gastrointestinal tract, urinary, and miscellaneous NMSS domains than those without FOG.

Conclusions

FOG in PD was associated with higher mHY stage, UPDRS part II score, and total NMSS score. Therefore, clinicians should consider non-motor, motor features and activities of daily living states for the proper management of FOG.

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Title: Factors associated with freezing of gait in patients with Parkinson’s disease
Authors: Seong-Min Choi
Hyun-Jung Jung
Geum-Jin Yoon
Byeong C. Kim
Publication date: 01-02-2019
Publisher: Springer International Publishing
Published in: Neurological Sciences / Issue 2/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3625-6

At a glance: The STEP trials

Springer Medicine

Factors associated with freezing of gait in patients with Parkinson’s disease

Abstract

Background

Method

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Method

Results

Conclusions

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