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Neurological Sciences

Published in:

01-11-2018 | Original Article

Analysis of the clinical features of early Parkinson’s disease with comparatively integrated intestinal function

Authors: Xiaoxue Guan, Yuchan Wang, Qun Li, Ming Wei, Lili Chen, Oumei Cheng

Published in: Neurological Sciences | Issue 11/2018

Abstract

Objective

Constipation is among the most frequently delineated nonmotor symptoms (NMS) with a high occurrence in Parkinson’s disease (PD). The purpose of our study was to investigate whether PD with comparatively integrated intestinal function (without constipation) in the early stage had different clinical features compared to constipated PD.

Method

We conducted a study of 105 consecutive de novo as well as early treated (treated for shorter than 3 months), aged 50 years or older outpatients. Subjects were administered motor and nonmotor questionnaires as well as constipation associated examinations. Then, we explored the distinctive features of nonconstipated contrasted to constipated PD by using univariate, multiple regression analysis and correlation analysis.

Results

Nonconstipated PD tended to have fewer motor deficits, as well as lower Hoehn and Yahr (H&Y) stage and they mainly presented as tremor-dominant (TD), while constipated group had a higher occurrence of posture instability and gait difficulty (PIGD); nonconstipated patients were inclined to live in urban area, the NMSloads and prevalence of NMS were lower compared to constipated ones. Correlation analysis found a discord between NMSloads and disease severity based on H&Y stage and motor scores in nonconstipated PD.

Conclusions

These results suggest that PD without constipation in early stage may represent a unique clinical phenotype, which may be more benign than PD with constipation.

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Title: Analysis of the clinical features of early Parkinson’s disease with comparatively integrated intestinal function
Authors: Xiaoxue Guan
Yuchan Wang
Qun Li
Ming Wei
Lili Chen
Oumei Cheng
Publication date: 01-11-2018
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 11/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3502-3

At a glance: The STEP trials

Springer Medicine

Analysis of the clinical features of early Parkinson’s disease with comparatively integrated intestinal function

Abstract

Objective

Method

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Method

Results

Conclusions

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