Skip to main content
Top
Published in: Neurological Sciences 8/2018

01-08-2018 | Original Article

Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease

Authors: Tamer Yazar, Hülya Olgun Yazar, Emel Zayimoğlu, Soner Çankaya

Published in: Neurological Sciences | Issue 8/2018

Login to get access

Abstract

Aim

In this study, the aim was to identify the incidence of sarcopenia and dynapenia according to disease stage among idiopathic Parkinson’s disease (IPD) patients and collect data to illuminate precautions related to reducing the disease load.

Method

The study was completed with 166 patients divided by stage according to modified Hoehn and Yahr (HYR) criteria and 249 healthy volunteers aged from 18 to 39 and 68 to 75 years met the inclusion criteria. In our prospective and cross-sectional study, patients with IPD according to “UK Brain Bank” diagnostic criteria had the Unified Parkinson’s Disease Rating Scale (UPDRS) and HYR scales applied. The patient and control groups had skeletal muscle mass index (SMMI), muscle power, and physical performance assessed. Diagnosis of sarcopenia used the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic criteria.

Results

In our study, in parallel with the increase in disease stage among IPD patients, the incidence of sarcopenia (led by severe sarcopenia) and dynapenia was high compared to that among the control group of the same age.

Conclusion

In the early stages of chronic progressive diseases like IPD, identification of sarcopenia and dynapenia is important considering the limitations of disease-preventive effects in treatments applied after diagnosis.
Literature
1.
go back to reference Torun Ş, Uysal M, Gücüyener D, Özdemir G (1995) Parkinson’s disease in Eskişehir, Turkey. Eur J Neurol 2:44–45 Torun Ş, Uysal M, Gücüyener D, Özdemir G (1995) Parkinson’s disease in Eskişehir, Turkey. Eur J Neurol 2:44–45
2.
go back to reference Xu XM, Dong MX, Feng X, Liu Y, Pan JX, Jia SY, Cao D, Wei YD (2018) Decreased serum proNGF concentration in patients with Parkinson’s disease. Neurol Sci Jan 39:91–96CrossRef Xu XM, Dong MX, Feng X, Liu Y, Pan JX, Jia SY, Cao D, Wei YD (2018) Decreased serum proNGF concentration in patients with Parkinson’s disease. Neurol Sci Jan 39:91–96CrossRef
4.
go back to reference Rosenberg I (1989) Summary comments: epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr 50:1231–1233CrossRef Rosenberg I (1989) Summary comments: epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr 50:1231–1233CrossRef
5.
go back to reference Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755–763CrossRefPubMed Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755–763CrossRefPubMed
7.
go back to reference Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E, Orwoll ES, Osteoporotic Fractures in Men Research Group (2007) Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc 55(8):1216–1223CrossRefPubMed Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E, Orwoll ES, Osteoporotic Fractures in Men Research Group (2007) Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc 55(8):1216–1223CrossRefPubMed
8.
go back to reference Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412–423CrossRefPubMedCentralPubMed Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412–423CrossRefPubMedCentralPubMed
9.
go back to reference Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB, Health ABC Study Investigators (2003) Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 51(11):1602–1609CrossRefPubMed Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB, Health ABC Study Investigators (2003) Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 51(11):1602–1609CrossRefPubMed
10.
go back to reference Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB, for the Health ABC Study (2006) The loss of skeletal muscle strength, mass and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 61(10):1059–1064CrossRefPubMed Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB, for the Health ABC Study (2006) The loss of skeletal muscle strength, mass and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 61(10):1059–1064CrossRefPubMed
11.
go back to reference Bianchi L, Ferrucci L, Cherubini A, Maggio M, Bandinelli S, Savino E, Brombo G, Zuliani G, Guralnik JM, Landi F, Volpato S (2016) The predictive value of the EWGSOP definition of sarcopenia: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci 71:259–264CrossRefPubMed Bianchi L, Ferrucci L, Cherubini A, Maggio M, Bandinelli S, Savino E, Brombo G, Zuliani G, Guralnik JM, Landi F, Volpato S (2016) The predictive value of the EWGSOP definition of sarcopenia: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci 71:259–264CrossRefPubMed
12.
go back to reference Barichella M, Pinelli G, Iorio L, Cassani E, Valentino A, Pusani C, Ferri V, Bolliri C, Pasqua M, Pezzoli G, Frazzitta G, Cereda E (2016) Sarcopenia and dynapenia in patients with parkinsonism. J Am Med Dir Assoc 17(7):640–646CrossRefPubMed Barichella M, Pinelli G, Iorio L, Cassani E, Valentino A, Pusani C, Ferri V, Bolliri C, Pasqua M, Pezzoli G, Frazzitta G, Cereda E (2016) Sarcopenia and dynapenia in patients with parkinsonism. J Am Med Dir Assoc 17(7):640–646CrossRefPubMed
13.
go back to reference Yürüyen M, Yavuzer H, Yavuzer S, Cengiz M, Demirdağ F, Kara Z et al (2017) Comparison of nutritional risk screening tools for predicting sarcopenia in hospitalized patients. Turk J Med Sci 47:1362–1369CrossRef Yürüyen M, Yavuzer H, Yavuzer S, Cengiz M, Demirdağ F, Kara Z et al (2017) Comparison of nutritional risk screening tools for predicting sarcopenia in hospitalized patients. Turk J Med Sci 47:1362–1369CrossRef
14.
go back to reference Yadigar S, Yavuzer H, Yavuzer S, Cengiz M, Yürüyen M, Döventaş A et al (2017) Primary sarcopenia in older people with normal nutrition. J Nutr Health Aging 21(8):849–854CrossRef Yadigar S, Yavuzer H, Yavuzer S, Cengiz M, Yürüyen M, Döventaş A et al (2017) Primary sarcopenia in older people with normal nutrition. J Nutr Health Aging 21(8):849–854CrossRef
15.
go back to reference Cruz-Jentoft AJ, Landi F, Topinková E, Michel JP (2010) Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care 13(1):1–7CrossRefPubMed Cruz-Jentoft AJ, Landi F, Topinková E, Michel JP (2010) Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care 13(1):1–7CrossRefPubMed
16.
18.
go back to reference Wang C, Bai L (2012) Sarcopenia in the elderly: basic and clinical issues. Geriatr Gerontol Int 12(3):388–396CrossRefPubMed Wang C, Bai L (2012) Sarcopenia in the elderly: basic and clinical issues. Geriatr Gerontol Int 12(3):388–396CrossRefPubMed
19.
go back to reference Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR (2008) Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 87(5):1562S–1566SCrossRefPubMed Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR (2008) Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr 87(5):1562S–1566SCrossRefPubMed
20.
go back to reference Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368–376CrossRefPubMed Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368–376CrossRefPubMed
21.
go back to reference Ramaker C, Marinus J, Stiggelbout AM, Van Hilten BJ (2002) Systematic evaluation of rating scales for impairment and disability in Parkinson's disease. Mov Disord 17:867–876CrossRefPubMed Ramaker C, Marinus J, Stiggelbout AM, Van Hilten BJ (2002) Systematic evaluation of rating scales for impairment and disability in Parkinson's disease. Mov Disord 17:867–876CrossRefPubMed
22.
23.
go back to reference Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L (1985) Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003 95(5):1851–1860CrossRef Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L (1985) Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003 95(5):1851–1860CrossRef
24.
go back to reference Trojano L, Papagno C (2018) Cognitive and behavioral disorders in Parkinson’s disease: an update. II: behavioral disorders. Neurol Sci 39(1):53–61CrossRefPubMed Trojano L, Papagno C (2018) Cognitive and behavioral disorders in Parkinson’s disease: an update. II: behavioral disorders. Neurol Sci 39(1):53–61CrossRefPubMed
25.
go back to reference Gazibara T, Kisic-Tepavcevic D, Svetel M, Tomic A, Stankoviç İ, Kostic V, Pekmezovic T (2017) Dynamics of change in self-reported disability among persons with Parkinson’s disease after 2 years of follow-up. Neurol Sci 38:1415–1421CrossRefPubMed Gazibara T, Kisic-Tepavcevic D, Svetel M, Tomic A, Stankoviç İ, Kostic V, Pekmezovic T (2017) Dynamics of change in self-reported disability among persons with Parkinson’s disease after 2 years of follow-up. Neurol Sci 38:1415–1421CrossRefPubMed
27.
go back to reference Seiler WO (2001) Clinical pictures of malnutrition in ill elderly subjects. Nutrition 17(6):496–498CrossRefPubMed Seiler WO (2001) Clinical pictures of malnutrition in ill elderly subjects. Nutrition 17(6):496–498CrossRefPubMed
28.
go back to reference Saji N, Arai H, Sakurai T, Toba K (2016) Frailty and sarcopenia: a new bridge to dementia. Nihon Rinsho 74(3):505–509PubMed Saji N, Arai H, Sakurai T, Toba K (2016) Frailty and sarcopenia: a new bridge to dementia. Nihon Rinsho 74(3):505–509PubMed
29.
go back to reference Bahat G, Tufan A, Tufan F, Kılıc C, Akpinar S, Kose M (2016) Cut-off points to identify sarcopenia according to European Working Group on Sarcopenia in Older People (EWGSOP) definition. Clin Nutr 2(6):35 Bahat G, Tufan A, Tufan F, Kılıc C, Akpinar S, Kose M (2016) Cut-off points to identify sarcopenia according to European Working Group on Sarcopenia in Older People (EWGSOP) definition. Clin Nutr 2(6):35
30.
go back to reference Kim H, Hirano H, Edahiro A, Ohara Y, Watanebe Y, Kojima N, Kim M, Hosoi E, Yoshida Y, Yoshida H, Shinkai S (2016) Sarcopenia: prevalence and associated factors based on different suggested definitions in community-dwelling older adults. Geriatr Gerontol Int 16(Suppl 1):110–122CrossRefPubMed Kim H, Hirano H, Edahiro A, Ohara Y, Watanebe Y, Kojima N, Kim M, Hosoi E, Yoshida Y, Yoshida H, Shinkai S (2016) Sarcopenia: prevalence and associated factors based on different suggested definitions in community-dwelling older adults. Geriatr Gerontol Int 16(Suppl 1):110–122CrossRefPubMed
31.
go back to reference Bahat G, Tufan A, Tufan F, Karan MA (2017) Significance of population differences and the methodology in determining the muscle mass cut-off points for sarcopenia. Geriatr Gerontol Int 17(3):521–522CrossRefPubMed Bahat G, Tufan A, Tufan F, Karan MA (2017) Significance of population differences and the methodology in determining the muscle mass cut-off points for sarcopenia. Geriatr Gerontol Int 17(3):521–522CrossRefPubMed
32.
go back to reference Van der Marck MA, Dicke HC, Uc EY, Kentin ZH, Borm GF, Bloem BR, Overeem S, Munneke M (2012) Body mass index in Parkinson’s disease: a meta-analysis. Parkinsonism Relat Disord 18(3):263–267CrossRefPubMed Van der Marck MA, Dicke HC, Uc EY, Kentin ZH, Borm GF, Bloem BR, Overeem S, Munneke M (2012) Body mass index in Parkinson’s disease: a meta-analysis. Parkinsonism Relat Disord 18(3):263–267CrossRefPubMed
33.
go back to reference Davide L, Vetrano DL, Pisciotta MS, Laudisio A, Lo Monaco MR, Onder G, Brandi V et al (2018) Sarcopenia in Parkinson disease: comparison of different criteria and association with disease severity. J Am Med Dir Assoc S1525-8610(17):30683–30687 Davide L, Vetrano DL, Pisciotta MS, Laudisio A, Lo Monaco MR, Onder G, Brandi V et al (2018) Sarcopenia in Parkinson disease: comparison of different criteria and association with disease severity. J Am Med Dir Assoc S1525-8610(17):30683–30687
34.
go back to reference Drey M, Hassman SE, Krenovsky JP, Hobert MA, Straub S, Elshehabi M et al (2017) Associations between early markers of Parkinson’s disease and sarcopenia. Front Aging Neurosci 9:53 eCollection 2017CrossRefPubMedCentralPubMed Drey M, Hassman SE, Krenovsky JP, Hobert MA, Straub S, Elshehabi M et al (2017) Associations between early markers of Parkinson’s disease and sarcopenia. Front Aging Neurosci 9:53 eCollection 2017CrossRefPubMedCentralPubMed
36.
go back to reference Lee YS, Kim SD, Kang HJ, Kim SW, Shin IS, Yoon JS, Kim JM (2017) Associations of upper arm and thigh circumferences with dementia and depression in Korean elders. Psychiatry Investig 14(2):150–157CrossRefPubMedCentralPubMed Lee YS, Kim SD, Kang HJ, Kim SW, Shin IS, Yoon JS, Kim JM (2017) Associations of upper arm and thigh circumferences with dementia and depression in Korean elders. Psychiatry Investig 14(2):150–157CrossRefPubMedCentralPubMed
Metadata
Title
Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease
Authors
Tamer Yazar
Hülya Olgun Yazar
Emel Zayimoğlu
Soner Çankaya
Publication date
01-08-2018
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 8/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-018-3439-6

Other articles of this Issue 8/2018

Neurological Sciences 8/2018 Go to the issue