Skip to main content
Top
Published in: Neurological Sciences 12/2017

01-12-2017 | Brief Communication

Acute toxic leukoencephalopathy associated with a non-prescription weight loss supplement: a report of two cases

Authors: Cesar E. Escamilla-Ocañas, Carlos R. Cámara-Lemarroy, Leonel Cantú-Martinez, Héctor R. Martínez

Published in: Neurological Sciences | Issue 12/2017

Login to get access

Abstract

Weight loss dietary supplements are used with some frequency by an increasingly overweight population. Some products are not adequately regulated and may pose potential health risks. We report two new cases of acute toxic leukoencephalopathy (ATL) due to the use of a supplement marketed as a thermogenic weight loss aid. ATL is a heterogeneous clinic-radiological entity that has been associated with various compounds, such as chemotherapeutic drugs and immunomodulators. It is characterized by an often reversible periventricular and infratentorial demyelination. The commercialization of non-regulated weight loss products continues to be a health risk in our population.
Literature
1.
go back to reference Lira-García C, Souto-Gallardo M, Bacardí-Gascón M et al (2008) Revisión de la efectividad de los ingredientes de productos alternativos para la pérdida de peso. Rev Salud pública 10:818–830CrossRefPubMed Lira-García C, Souto-Gallardo M, Bacardí-Gascón M et al (2008) Revisión de la efectividad de los ingredientes de productos alternativos para la pérdida de peso. Rev Salud pública 10:818–830CrossRefPubMed
2.
go back to reference Timbo BB, Ross MP, McCarthy PV et al (2006) Dietary supplements in a national survey: prevalence of use and reports of adverse events. J Am Diet Assoc 106:1966–1974CrossRefPubMed Timbo BB, Ross MP, McCarthy PV et al (2006) Dietary supplements in a national survey: prevalence of use and reports of adverse events. J Am Diet Assoc 106:1966–1974CrossRefPubMed
3.
4.
go back to reference Rimkus Cde M, Andrade CS, Leite Cda C et al (2014) Toxic leukoencephalopathies, including drug, medication, environmental, and radiation-induced encephalopathic syndromes. Semin Ultrasound CT MR 35:97–117CrossRefPubMed Rimkus Cde M, Andrade CS, Leite Cda C et al (2014) Toxic leukoencephalopathies, including drug, medication, environmental, and radiation-induced encephalopathic syndromes. Semin Ultrasound CT MR 35:97–117CrossRefPubMed
5.
go back to reference Olivas-Chacón CI, Treviño-García M, Chua-Tjuan JJ et al (2015) Leukoencephalopathy changes on magnetic resonance imaging associated with a thermogenic dietary supplement (Thermatrim). Porc (Bay Univ Med Cent) 28:389–391 Olivas-Chacón CI, Treviño-García M, Chua-Tjuan JJ et al (2015) Leukoencephalopathy changes on magnetic resonance imaging associated with a thermogenic dietary supplement (Thermatrim). Porc (Bay Univ Med Cent) 28:389–391
6.
go back to reference McKinney AM, Kieffer SA, Paylor RT et al (2009) Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol 193:192–206CrossRefPubMed McKinney AM, Kieffer SA, Paylor RT et al (2009) Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol 193:192–206CrossRefPubMed
7.
go back to reference Osuna MT, Querol L, Olivas-Chacón CI et al (2015) Neuropatía desmielinizante y leucoencefalopatía tóxicas en pacientes que toman los productos adelgazantes Thermatrim® y Pura Alegría®. Rev Neurol 61:527–528PubMed Osuna MT, Querol L, Olivas-Chacón CI et al (2015) Neuropatía desmielinizante y leucoencefalopatía tóxicas en pacientes que toman los productos adelgazantes Thermatrim® y Pura Alegría®. Rev Neurol 61:527–528PubMed
8.
go back to reference Da Silva WV, de Andrade Gomes Silva MI, Tavares Toscano L et al (2014) Supplementation prevalence and adverse effects in physical exercise practitioners. Nut Hosp 29:158–165 Da Silva WV, de Andrade Gomes Silva MI, Tavares Toscano L et al (2014) Supplementation prevalence and adverse effects in physical exercise practitioners. Nut Hosp 29:158–165
Metadata
Title
Acute toxic leukoencephalopathy associated with a non-prescription weight loss supplement: a report of two cases
Authors
Cesar E. Escamilla-Ocañas
Carlos R. Cámara-Lemarroy
Leonel Cantú-Martinez
Héctor R. Martínez
Publication date
01-12-2017
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 12/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-017-3028-0

Other articles of this Issue 12/2017

Neurological Sciences 12/2017 Go to the issue