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01-01-2017 | Original Article

Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis

Authors: Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang, Anmu Xie

Published in: Neurological Sciences | Issue 1/2017

Abstract

Rapid eye movement sleep behavior disorder (RBD) is thought to be one of the most frequent preceding symptoms of Parkinson’s disease (PD). However, the prevalence of RBD in PD stated in the published studies is still inconsistent. We conducted a meta and meta-regression analysis in this paper to estimate the pooled prevalence. We searched the electronic databases of PubMed, ScienceDirect, EMBASE and EBSCO up to June 2016 for related articles. STATA 12.0 statistics software was used to calculate the available data from each research. The prevalence of RBD in PD patients in each study was combined to a pooled prevalence with a 95 % confidence interval (CI). Subgroup analysis and meta-regression analysis were performed to search for the causes of the heterogeneity. A total of 28 studies with 6869 PD cases were deemed eligible and included in our meta-analysis based on the inclusion and exclusion criteria. The pooled prevalence of RBD in PD was 42.3 % (95 % CI 37.4–47.1 %). In subgroup analysis and meta-regression analysis, we found that the important causes of heterogeneity were the diagnosis criteria of RBD and age of PD patients (P = 0.016, P = 0.019, respectively). The results indicate that nearly half of the PD patients are suffering from RBD. Older age and longer duration are risk factors for RBD in PD. We can use the minimal diagnosis criteria for RBD according to the International Classification of Sleep Disorders to diagnose RBD patients in our daily work if polysomnography is not necessary.

Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW (1986) Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 9(2):293–308PubMed

Plazzi G (2004) REM sleep behavior disorders in Parkinson’s disease and other Parkinsonian disorders. Sleep Med 5(2):195–199. doi:10.1016/j.sleep.2004.01.003 CrossRefPubMed

Mollenhauer B, Zimmermann J, Sixel-Doring F, Focke NK, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Trautmann E, Zetterberg H, Taylor P, Friede T, Trenkwalder C, DeNoPa Study G (2016) Monitoring of 30 marker candidates in early Parkinson disease as progression markers. Neurology. doi:10.1212/WNL.0000000000002651 PubMedCentral

Fereshtehnejad SM, Romenets SR, Anang JB, Latreille V, Gagnon JF, Postuma RB (2015) New clinical subtypes of parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol 72(8):863–873. doi:10.1001/jamaneurol.2015.0703 CrossRefPubMed

Zhang JR, Chen J, Yang ZJ, Zhang HJ, Fu YT, Shen Y, He PC, Mao CJ, Liu CF (2016) Rapid eye movement sleep behavior disorder symptoms correlate with domains of cognitive impairment in parkinson’s disease. Chin Med J 129(4):379–385. doi:10.4103/0366-6999.176077 CrossRefPubMedPubMedCentral

Arnaldi D, Morbelli S, Brugnolo A, Girtler N, Picco A, Ferrara M, Accardo J, Buschiazzo A, de Carli F, Pagani M, Nobili F (2016) Functional neuroimaging and clinical features of drug naive patients with de novo Parkinson’s disease and probable RBD. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2016.05.031 PubMed

Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Seki M, Iwasawa S, Suzuki N (2012) REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire. J Neurol 259(8):1606–1612. doi:10.1007/s00415-011-6386-1 CrossRefPubMed

Kotagal V, Albin RL, Muller ML, Koeppe RA, Chervin RD, Frey KA, Bohnen NI (2012) Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Ann Neurol 71(4):560–568. doi:10.1002/ana.22691 CrossRefPubMedPubMedCentral

Bjornara KA, Dietrichs E, Toft M (2013) REM sleep behavior disorder in Parkinson’s disease—is there a gender difference? Parkinsonism Relat Disord 19(1):120–122. doi:10.1016/j.parkreldis.2012.05.027 CrossRefPubMed

10.

Suzuki K, Miyamoto T, Miyamoto M, Watanabe Y, Suzuki S, Tatsumoto M, Iwanami M, Sada T, Kadowaki T, Numao A, Hashimoto K, Sakuta H, Hirata K (2013) Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson’s disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire. BMC Neurol 13:18. doi:10.1186/1471-2377-13-18 CrossRefPubMedPubMedCentral

11.

Poryazova R, Oberholzer M, Baumann CR, Bassetti CL (2013) REM sleep behavior disorder in Parkinson’s disease: a questionnaire-based survey. J Clin Sleep Med 9(1):55A–59A. doi:10.5664/jcsm.2340

12.

Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, Hu MT (2014) REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson’s disease. J Neurol Neurosurg Psychiatry 85(5):560–566. doi:10.1136/jnnp-2013-306104 CrossRefPubMed

13.

Mahale R, Yadav R, Pal PK (2014) Rapid eye movement sleep behaviour disorder in young- and older-onset Parkinson disease: a questionnaire-based study. Sleep Med 15(6):642–646. doi:10.1016/j.sleep.2014.01.022 CrossRefPubMed

14.

Swallow DM, Lawton MA, Grosset KA, Malek N, Smith CR, Bajaj NP, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams N, Wood NW, Grosset DG, Consortium PRC (2016) Variation in recent onset Parkinson’s Disease: implications for prodromal detection. J Parkinson’s Dis 6(2):289–300. doi:10.3233/JPD-150741 CrossRef

15.

Chahine LM, Xie SX, Simuni T, Tran B, Postuma R, Amara A, Oertel WH, Iranzo A, Scordia C, Fullard M, Linder C, Purri R, Darin A, Rennert L, Videnovic A, Del Riva P, Weintraub D (2016) Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder. Parkinsonism Relat Disord 27:102–106. doi:10.1016/j.parkreldis.2016.03.006 CrossRefPubMed

16.

Kim CS, Sung YH, Kang MJ, Park KH (2016) Rapid eye movement sleep behavior disorder in Parkinson’s disease: a preliminary study. J Mov Disord 9(2):114–119. doi:10.14802/jmd.15039 CrossRefPubMedPubMedCentral

17.

Lee JE, Kim KS, Shin HW, Sohn YH (2010) Factors related to clinically probable REM sleep behavior disorder in Parkinson disease. Parkinsonism Relat Disord 16(2):105–108. doi:10.1016/j.parkreldis.2009.08.005 CrossRefPubMed

18.

Vibha D, Shukla G, Singh S, Goyal V, Srivastava AK, Behari M (2010) Lower prevalence of sleep disturbances in familial versus sporadic Parkinson’s disease: a questionnaire based study. J Neurol Sci 295(1–2):27–30. doi:10.1016/j.jns.2010.05.024 CrossRefPubMed

19.

Bugalho P, da Silva JA, Neto B (2011) Clinical features associated with REM sleep behavior disorder symptoms in the early stages of Parkinson’s disease. J Neurol 258(1):50–55. doi:10.1007/s00415-010-5679-0 CrossRefPubMed

20.

Vibha D, Shukla G, Goyal V, Singh S, Srivastava AK, Behari M (2011) RBD in Parkinson’s disease: a clinical case control study from North India. Clin Neurol Neurosurg 113(6):472–476. doi:10.1016/j.clineuro.2011.02.007 CrossRefPubMed

21.

Kim YE, Yang HJ, Yun JY, Kim HJ, Lee JY, Jeon BS (2014) REM sleep behavior disorder in Parkinson disease: association with abnormal ocular motor findings. Parkinsonism Relat Disord 20(4):444–446. doi:10.1016/j.parkreldis.2013.12.003 CrossRefPubMed

22.

Munhoz RP, Teive HA (2014) REM sleep behaviour disorder: how useful is it for the differential diagnosis of parkinsonism? Clin Neurol Neurosurg 127:71–74. doi:10.1016/j.clineuro.2014.09.014 CrossRefPubMed

23.

Kim YE, Jeon BS, Yang HJ, Ehm G, Yun JY, Kim HJ, Kim JM (2014) REM sleep behavior disorder: association with motor complications and impulse control disorders in Parkinson’s disease. Parkinsonism Relat Disord 20(10):1081–1084. doi:10.1016/j.parkreldis.2014.03.022 CrossRefPubMed

24.

Nomura T, Inoue Y, Takigawa H, Nakashima K (2012) Comparison of REM sleep behaviour disorder variables between patients with progressive supranuclear palsy and those with Parkinson’s disease. Parkinsonism Relat Disord 18(4):394–396. doi:10.1016/j.parkreldis.2011.10.018 CrossRefPubMed

25.

Nomura T, Inoue Y, Hogl B, Uemura Y, Yasui K, Sasai T, Namba K, Nakashima K (2011) Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinson’s disease and multiple system atrophy. Psychiatry Clin Neurosci 65(3):264–271. doi:10.1111/j.1440-1819.2011.02201.x CrossRefPubMed

26.

Ferri R, Fulda S, Cosentino FI, Pizza F, Plazzi G (2012) A preliminary quantitative analysis of REM sleep chin EMG in Parkinson’s disease with or without REM sleep behavior disorder. Sleep Med 13(6):707–713. doi:10.1016/j.sleep.2012.01.003 CrossRefPubMed

27.

Romenets SR, Gagnon JF, Latreille V, Panniset M, Chouinard S, Montplaisir J, Postuma RB (2012) Rapid eye movement sleep behavior disorder and subtypes of Parkinson’s disease. Mov Disor 27(8):996–1003. doi:10.1002/mds.25086 CrossRef

28.

Plomhause L, Dujardin K, Duhamel A, Delliaux M, Derambure P, Defebvre L, Monaca Charley C (2013) Rapid eye movement sleep behavior disorder in treatment-naive Parkinson disease patients. Sleep Med 14(10):1035–1037. doi:10.1016/j.sleep.2013.04.018 CrossRefPubMed

29.

Ferri R (2012) The time structure of leg movement activity during sleep: the theory behind the practice. Sleep Med 13(4):433–441. doi:10.1016/j.sleep.2011.10.027 CrossRefPubMed

30.

Gong Y, Xiong KP, Mao CJ, Shen Y, Hu WD, Huang JY, Han F, Chen R, Liu CF (2014) Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Med 15(6):647–653. doi:10.1016/j.sleep.2013.12.021 CrossRefPubMed

31.

Chahine LM, Kauta SR, Daley JT, Cantor CR, Dahodwala N (2014) Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity. Parkinsonism Relat Disord 20(7):766–771. doi:10.1016/j.parkreldis.2014.04.011 CrossRefPubMedPubMedCentral

32.

Alatriste-Booth V, Rodriguez-Violante M, Camacho-Ordonez A, Cervantes-Arriaga A (2015) Prevalence and correlates of sleep disorders in Parkinson’s disease: a polysomnographic study. Arq Neuropsiquiatr 73(3):241–245. doi:10.1590/0004-282X20140228 CrossRefPubMed

33.

Bayard S, Dauvilliers Y, Yu H, Croisier-Langenier M, Rossignol A, Charif M, Geny C, Carlander B, Cochen De Cock V (2014) Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson’s disease. ParkinsonismRelat Disord 20(12):1411–1414. doi:10.1016/j.parkreldis.2014.09.020 CrossRef

34.

Neikrug AB, Avanzino JA, Liu L, Maglione JE, Natarajan L, Corey-Bloom J, Palmer BW, Loredo JS, Ancoli-Israel S (2014) Parkinson’s disease and REM sleep behavior disorder result in increased non-motor symptoms. Sleep Med 15(8):959–966. doi:10.1016/j.sleep.2014.04.009 CrossRefPubMedPubMedCentral

35.

American Academy of Sleep Medicine (2001) International classification of sleep disorders. Diagnostic and Coding Manual. American Academy of Sleep Medicine, Westchester

36.

American Academy of Sleep Medicine (2005) International classification of sleep disorders. Diagnostic and coding manual, 2nd edn. American Academy of Sleep Medicine, Westchester

37.

Zintzaras E, Ioannidis JP (2005) Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 28(2):123–137. doi:10.1002/gepi.20048 CrossRefPubMed

38.

Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295(6):676–680. doi:10.1001/jama.295.6.676 CrossRefPubMed

39.

Scaglione C, Vignatelli L, Plazzi G, Marchese R, Negrotti A, Rizzo G, Lopane G, Bassein L, Maestri M, Bernardini S, Martinelli P, Abbruzzese G, Calzetti S, Bonuccelli U, Provini F, Coccagna G, Bologna GP, Pisa Universities group for the study of REMSBDiPsD (2005) REM sleep behaviour disorder in Parkinson’s disease: a questionnaire-based study. Neurol Sci 25(6):316–321. doi:10.1007/s10072-004-0364-7 CrossRefPubMed

40.

Zhao QF, Tan L, Wang HF, Jiang T, Tan MS, Tan L, Xu W, Li JQ, Wang J, Lai TJ, Yu JT (2016) The prevalence of neuropsychiatric symptoms in Alzheimer’s disease: systematic review and meta-analysis. J Affect Disord 190:264–271. doi:10.1016/j.jad.2015.09.069 CrossRefPubMed

Title: Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis
Authors: Xiaona Zhang
Xiaoxuan Sun
Junhong Wang
Liou Tang
Anmu Xie
Publication date: 01-01-2017
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 1/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-016-2744-1

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Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis

Abstract

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