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Neurological Sciences
Published in: Neurological Sciences 10/2015

01-10-2015 | Original Article

Retinol-binding protein-4 and hs-CRP levels in patients with migraine

Authors: Nermin Tanik, Asuman Celikbilek, Aslı Metin, Ayse Yesim Gocmen, Levent Ertugrul Inan

Published in: Neurological Sciences | Issue 10/2015

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Abstract

Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine. The release of proinflammatory cytokines during migraine results in recurrent sterile neurogenic inflammation. This study aimed to determine the correlation between RBP4 and hs-CRP levels, and migraine, which is considered an inflammatory disease. The study included 48 migraine patients and 40 age- and gender-matched controls. Migraine was diagnosed according to International Classification of Headache Disorders-II. The serum RBP4 level was measured using a commercial ELISA kit and hs-CRP was measured using an enzyme immunoassay test kit. The serum RBP4 level was significantly lower in the migraine patients than in the controls (P < 0.001), whereas the hs-CRP level was significantly higher in the migraine patients (P < 0.001). RBP4 and hs-CRP levels did not differ between the migraine patients with and without aura (P > 0.05). Migraine headache severity, frequency and duration were not correlated with serum RBP or hs-CRP levels (P > 0.05). The observed high hs-CRP level and low RBP4 level in migraine patients suggest that vitamin A might play a major role in the pathogenesis of migraine. It is known that inflammation is a key factor in many diseases. Additional research might result in a better understanding of the anti-inflammatory effects of vitamin A.
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Metadata
Title
Retinol-binding protein-4 and hs-CRP levels in patients with migraine
Authors
Nermin Tanik
Asuman Celikbilek
Aslı Metin
Ayse Yesim Gocmen
Levent Ertugrul Inan
Publication date
01-10-2015
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 10/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-015-2262-6

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