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01-09-2015 | Original Article

Somatosensory evoked potentials and blood lactate levels

Authors: Valentina Perciavalle, Giovanna Alagona, Giulia De Maria, Giuseppe Rapisarda, Erminio Costanzo, Vincenzo Perciavalle, Marinella Coco

Published in: Neurological Sciences | Issue 9/2015

Abstract

We compared, in 20 subjects, the effects of high blood lactate levels on amplitude and latency of P1, N1, P2 and N2 components of lower limb somatosensory evoked potential (SEP), an useful, noninvasive tool for assessing the transmission of the afferent volley from periphery up to the cortex. SEPs were recorded from CPz located over the somatosensory vertex and referenced to FPz with a clavicle ground. Measurements were carried out before, at the end as well as 10 and 20 min after the conclusion of a maximal exercise carried out on a mechanically braked cycloergometer. After the exercise, P2–N2 amplitudes as well as latency of P1 and N1 components showed small but significant reductions. On the contrary, latency of N2 component exhibited a significant increase after the exercise’s conclusion. These results suggest that blood lactate appears to have a protective effect against fatigue, at least at level of primary somatosensory cortex, although at the expense of efficiency of adjacent areas.

Meeusen R, Watson P, Hasegawa H, Roelands B, Piacentini MF (2007) Brain neurotransmitters in fatigue and overtraining. Appl Physiol Nutr Metab 32:857–864CrossRefPubMed

Bangsbo J (1998) Quantification of anaerobic energy production during intense exercise. Med Sci Sports Exerc 130:47–52CrossRef

Medbø JI, Tabata I (1993) Anaerobic energy release in working muscle during 30 s to 3 min of exhausting bicycling. J Appl Physiol 74:1654–1660

Dalsgaard MK, Ide K, Cai Y, Quistorff B, Secher NH (2002) The intent to exercise influences the cerebral O₂/carbohydrate uptake ratio in humans. J Physiol 540:681–689PubMedCentralCrossRefPubMed

Dalsgaard MK, Quistorff B, Danielsen ER, Selmer C, Vogelsang T, Secher NH (2004) A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. J Physiol 554:571–578PubMedCentralCrossRefPubMed

Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C (2008) Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 322:1551–1555CrossRefPubMed

Coco M, Di Corrado D, Calogero RA, Va Perciavalle, Maci T, Perciavalle V (2009) Attentional processes and blood lactate levels. Brain Res 1302:205–211CrossRefPubMed

Coco M, Alagona G, Rapisarda G, Costanzo E, Calogero RA, Va Perciavalle, Perciavalle V (2010) Elevated blood lactate is associated with increased motor cortex excitability. Somatosens Mot Res. doi:10.3109/08990220903471765

Coco M, Alagona G, Va Perciavalle, Cicirata V, Perciavalle V (2011) Spinal cord excitability is not influenced by elevated blood lactate levels. Somatosens Mot Res 28:19–24CrossRefPubMed

10.

Coco M, Alagona G, Perciavalle Va, Rapisarda G, Costanzo E, Perciavalle V (2013) Brainstem excitability is not influenced by blood lactate levels. Somatosens Mot Res 30:90–95CrossRefPubMed

11.

Coco M, Caggia S, Musumeci G, Perciavalle V, Graziano AC, Pannuzzo G, Cardile V (2013) Sodium l-lactate differently affects brain-derived neurotrophic factor, inducible nitric oxide synthase, and heat shock protein 70 kDa production in human astrocytes and SH-SY5Y cultures. J Neurosci Res 91:313–320. doi:10.1002/jnr.23154 CrossRefPubMed

12.

Coco M, Alagona G, De Maria G, Rapisarda G, Costanzo E, Perciavalle V, Va Perciavalle (2014) Relationship of high blood lactate levels with latency of visual-evoked potentials. Neurol Sci. doi:10.1007/s10072-014-2015-y PubMed

13.

Allison T, McCarthy G, Jones SJ, Jones SJ (1991) Potentials evoked in human and monkey cerebral cortex by stimulation of the median nerve. A review of scalp and intracranial recordings. Brain 114:2465–2503CrossRefPubMed

14.

Kakigi R, Jones SJ (1986) Influence of concurrent tactile stimulation on somatosensory evoked potentials following posterior tibial nerve stimulation in man. Electroencephalogr Clin Neurophysiol 65:118–129CrossRefPubMed

15.

Kakigi R, Koyama S, Hoshiyama M, Shimojo M, Kitamura Y, Watanabe S (1995) Topography of somatosensory evoked magnetic fields following posterior tibial nerve stimulation. Electroencephalogr Clin Neurophysiol 95:127–134CrossRefPubMed

16.

Frot M, Mauguière F (1999) Timing and spatial distribution of somatosensory responses recorded in the upper bank of the sylvian fissure (SII area) in humans. Cereb Cortex 9:854–863CrossRefPubMed

17.

Frot M, Garcìa-Larrea L, Marc G, Mauguière F (2001) Responses of the suprasylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordings. Pain 94:65–73CrossRefPubMed

18.

Hari R, Forss N (1999) Magnetoencephalography in the study of human somatosensory cortical processing. Phil Trans R Soc Lond B 354:1145–1154CrossRef

19.

Kakigi R, Hoshiyama M, Shimojo M, Naka D, Yamasaki H, Watanabe S, Xiang J, Maeda K, Lam K, Itomi K, Nakamura A (2000) The somatosensory evoked magnetic fields. Prog Neurobiol 61:495–523CrossRefPubMed

20.

Green JM, McLester JR, Crews TR, Wickwire PJ, Pritchett RC, Redden A (2005) RPE-lactate dissociation during extended cycling. Eur J Appl Physiol 94:145–150CrossRefPubMed

21.

Mc Naughton LR, Thompson D, Philips G, Backx K, Crickmore L (2002) A comparison of the lactate Pro, Accusport, Analox GM7 and Kodak Ektachem lactate analysers in normal, hot and humid conditions. Int J Sports Med 23:130–135CrossRefPubMed

22.

Kristensen GB, Christensen NG, Thue G, Sandberg S (2005) Between-lot variation in external quality assessment of glucose: clinical importance and effect on participant performance evaluation. Clin Chem 51:1632–1636CrossRefPubMed

23.

DeLisa JA, Lee HJ, Lai KS, Spielhocz N, MacKenzie K (1994) Manual of nerve conduction velocity and and clinical neurophysiology, 3rd edn. Raven Press, New York, p 494

24.

Seyal M, Emerson RG, Pedley TA (1983) Spinal and early scalp-recorded components of the somatosensory evoked potential following stimulation of the posterior tibial nerve. Electroencephalogr Clin Neurophysiol 55:320–330CrossRefPubMed

25.

Nuwer M (1998) Fundamentals of evoked potentials and common clinical applications today. Electroencephalogr Clin Neurophysiol 106:142–148CrossRefPubMed

26.

Barrett EF, Barrett JN (1982) Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol 323:117–144PubMedCentralCrossRefPubMed

27.

Lauritzen KH, Morland C, Puchades M, Holm-Hansen S, Hagelin EM, Lauritzen F, Attramadal H, Storm-Mathisen J, Gjedde A, Bergersen LH (2014) Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex 24(10):2784–2795. doi:10.1093/cercor/bht136 CrossRefPubMed

Title: Somatosensory evoked potentials and blood lactate levels
Authors: Valentina Perciavalle
Giovanna Alagona
Giulia De Maria
Giuseppe Rapisarda
Erminio Costanzo
Vincenzo Perciavalle
Marinella Coco
Publication date: 01-09-2015
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 9/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-015-2210-5

At a glance: The STEP trials

Springer Medicine

Somatosensory evoked potentials and blood lactate levels

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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