Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Neurological Sciences
Published in: Neurological Sciences 1/2015

01-05-2015 | CLINICAL ASPECTS OF HEADACHES

Headache in multiple sclerosis and autoimmune disorders

Authors: L. La Mantia, V. Prone

Published in: Neurological Sciences | Special Issue 1/2015

Login to get access

Abstract

The headache may be considered among the neuropathic pain syndromes of multiple sclerosis (MS). Several studies have showed that it is more frequent in MS patients than in controls or general population. Headache may occur at the pre-symptomatic phase, at clinical onset and during the course of the disease. Tension-type headache and migraine without aura are the most common primary headaches reported in MS patients. The disease-modifying therapies, such as interferons, may cause or exacerbate headache, although the new available treatments do not seem to increase the risk of pain. Pharmacological and not pharmacological approach may be considered in selected patients to prevent the risk of headache, ameliorate quality of life and increase the adherence to treatment.
Literature
1.
Kister I, Caminero AB, Herbert J, Lipton RB (2010) Tension-type headache and migraine in multiple sclerosis. Curr Pain Headache Rep 14(6):441–448CrossRefPubMed
2.
Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT (2013) Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain 154(5):632–642CrossRefPubMed
3.
La Mantia L (2009) Headache and multiple sclerosis: clinical and therapeutic correlations. Neurol Sci 30(Suppl 1):S23–S26CrossRefPubMed
4.
5.
6.
Nicoletti A, Patti F, Lo Fermo S, Liberto A, Castiglione A, Laisa P, Garifoli A, La Naia F, Maimone D, Sorbello V, Contrafatto D, Zappia M (2008) Headache and multiple sclerosis: a population based case–control study in Catania, Sicily. Cephalalgia 28:1163–1169CrossRefPubMed
7.
Galer BS, Lipton RB, Weinstein S, Bello L, Solomon S (1990) Apoplectic headache and oculomotor nerve palsy: an unusual presentation of multiple sclerosis. Neurology 40:1465–1466CrossRefPubMed
8.
9.
Mijajlović MD, Aleksić VM, Covičković Šternić NM (2014) Cluster headache as a first manifestation of multiple sclerosis: case report and literature review. Neuropsychiatr Dis Treat 25(10):2269–2274CrossRef
10.
Compston N, McAlpine D (1952) Some aspects of the natural history of disseminated sclerosis. Q J Med 21:135–167PubMed
11.
Martinelli Boneschi F, Colombo B, Annovazzi P, Martinelli V, Bernasconi L, Solaro C, Comi G (2008) Lifetime and actual prevalence of pain and headache in multiple sclerosis. Multiple Scler 14:514–521CrossRef
12.
Kurtzke JF, Beebe GW, Nagler B, Auth TL, Kurland LT, Nefzger MD (1968) Studies on natural history of multiple sclerosis. Acta Neurol Scand 44:467–494CrossRefPubMed
13.
Yetimalar Y, Secil Y, Inceoglu AK, Eren S, Basoglu M (2008) Unusual primary manifestations of multiple sclerosis. NZ Med J 121:47–59
14.
Lebrun C, Bensa C, Debouverie H, De Seze J et al (2008) Unexpected multiple sclerosis: follow-up of 30 patients with MRI and clinical conversion profile. J Neurol Neurosurg Psychiatry 79:195–198CrossRefPubMed
15.
Granberg T, Martola J, Kristoffersen-Wiberg M, Aspelin P, Fredrikson S (2013) Radiologically isolated syndrome–incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review. Mult Scler 19(3):271–280CrossRefPubMed
16.
Freedman MS, Gray TA (1989) Vascular headache: a presenting symptom of multiple sclerosis. Can J Neurol Sci 16:63–66PubMed
17.
Gee JR, Chang J, Dublin AB, Vijayan N (2005) The association of brainstem lesions with migraine-like headache: an imaging study of multiple sclerosis. Headache 45:670–677CrossRefPubMed
18.
Tortorella P, Rocca MA, Colombo B, Annovazzi P, Comi G, Filippi M (2006) Assessment of MRI abnormalities of the brain stem from patients with migraine and multiple sclerosis. J Neurol Sci 244:137–141CrossRefPubMed
19.
20.
Ergün U, Ozer G, Sekercan S (2009) Headaches in the different phases of relapsing-remitting multiple sclerosis: a tendency for stabbing headaches during relapses. Neurologist 15:212–216CrossRefPubMed
21.
Liu FC, Fuh JL, Wang SJ (2008) Symptomatic trigeminal autonomic cephalalgia associated with allodynia in a patients with multiple sclerosis. J Chin Med Assess 71:583–586CrossRef
22.
Nelley LK, Goodin DS, Goodkin DE, Hauser SL (1996) Side effect profile of interferon beta-1b in MS: results of an open trial. Neurology 46:552–554CrossRef
23.
Filippini G, Munari L, Incorvaia B, Ebers GC, Polman C, D’Amico R, Rice GP (2003) Interferons in relapsing remitting multiple sclerosis: a systematic review. Lancet 361(9357):545–552CrossRefPubMed
24.
D’Amico D, La Mantia L, Rigamonti A (2004) Prevalence of primary headaches in people with multiple sclerosis. Cephalalgia 24:980–984CrossRefPubMed
25.
26.
Abb L, Schaltebrand G (1956) Statistische Untersuchungen zum Problem der multiplen Sklerose. II. Mitteilung das Krankheitsbild der multiplen Sklerose. Dtsh Z Nervenheilkd 174:201–218
27.
Bonduelle M, Albaranes R (1962) E ´ tude statistique de 145 case de scle´rose en plaque. Semin Hop Paris 68:3762–3773
28.
Poser CM, Presthus J, Horsda O (1966) Clinical characteristics of autopsy-proved multiple sclerosis. Neurology 16:791–798CrossRef
29.
30.
31.
Rolak LA, Brown S (1990) Headaches and multiple sclerosis: a clinical study and review of the literature. J Neurol 237:300–302CrossRefPubMed
32.
Pollmann W, Feneberg W, Erasmus LP (2004) Pain in multiple sclerosis—a still underestimated problem. Nervenartz 75:135–140CrossRef
33.
Vacca G, Marano E, Brescia Morra V, Lanzillo R, de Vito M, Parente E, Orefice G (2007) Multiple sclerosis and headache co-morbidity. A case–control study. Neurol Sci 28:133–135CrossRefPubMed
34.
Villani V, Prosperini L, Ciuffoli A, Pizzolato R, Salvetti M, Pozzilli C, Sette G (2008) Primary headache and multiple sclerosis: preliminary results of a prospective study. Neurol Sci 29:S146–S148CrossRefPubMed
35.
Putzki N, Pfriem A, Limmroth V, Yaldizli O, Tettenborn B, Diener HC, Katsarava Z (2009) Prevalence of migraine, tensiontype headache and trigeminal neuralgia in multiple sclerosis. Eur J Neurol 16:262–267CrossRefPubMed
36.
Kister I, Caminero AB, Monteith TS (2010) Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course. J Headache Pain 11(5):417–425CrossRefPubMedCentralPubMed
37.
Martínez Sobrepera HJ, Cabrera Gómez JA, Tuero Iglesias A (2001) Exogenous factors in the aetiology of multiple sclerosis in Cuba. A study of cases and controls. Rev Neurol 33:931–937PubMed
38.
Kister I, Munger K, Herbert J, Ascherio A (2010) Increased Risk of Multiple Sclerosis among Women with Migraine in the Nurses’ Health Study II Poster P01.172 presented at the American Academy of Neurology Annual Meeting, Toronto, Canada
39.
Miller DH, Khan OA, Sheremata WA, Blumhardt LA, Rice GPA, Libonati MA, Willmer-Hulme AJ, Dalton CM, Miszkiel KA, O’Connor PW for the International Natalizumab Multiple Sclerosis Trial Group (2003) A controlled trial of Natalizumab for relapsing multiple sclerosis. N Engl J Med 348:15–23
40.
Kappos L, Radue EW, O’Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K, Agoropoulou C, Leyk M, Zhang-Auberson L, Burtin P, for the FREEDOMS Study Group (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362:387–401
41.
Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser, MT, Yang M, Sheikh SI, Dawson KT for the DEFINE Study Investigators (2012) Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 367:12
42.
Miller AE, Wolinsky JS, Kappos L, Comi G, Freedman MS, Olsson TP, Bauer D, Benamor M, Truffinet P, O’Connor PW for the TOPIC Study Group (2014) Oral teriflunomide for patients with a fi rst clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol 13:977–986
Metadata
Title
Headache in multiple sclerosis and autoimmune disorders
Authors
L. La Mantia
V. Prone
Publication date
01-05-2015
Publisher
Springer Milan
Published in
Neurological Sciences / Issue Special Issue 1/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-015-2146-9

Other articles of this Special Issue 1/2015

Neurological Sciences 1/2015 Go to the issue

NEWS ON TREATMENT OF PRIMARY HEADACHES AND NEUROSTIMULATION

Emerging treatments for the primary headache disorders

BRIEF COMMUNICATION

Familial cluster headache in an Italian case series

CLINICAL ASPECTS OF HEADACHES

Migraine in perimenopausal women

WORKSHOP – SOCIAL ASPECTS OF HEADACHES

Approaches to treatments of chronic migraine associated with medication overuse: a comparison between different intensity regimens

MIGRAINE - NEWS IN PATHOPHYSIOLOGY

Onabotulinum toxin A (Botox) for chronic migraine treatment: an Italian experience

FICEF SYMPOSIUM

Migraine and lifestyle in childhood