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01-05-2014 | SESSION IV UNCONVENTIONAL TREATMENTS

Riboflavin and migraine: the bridge over troubled mitochondria

Authors: Bruno Colombo, Lorenzo Saraceno, Giancarlo Comi

Published in: Neurological Sciences | Special Issue 1/2014

Abstract

Brain energy metabolism has been found to be disturbed in migraine. A mitochondrial defect may reduce the threshold for migraine attacks both increasing neuronal excitability and leading migrainous brain to a hyper-responsiveness to triggering stimuli. Riboflavin, a major co-factor in oxidative metabolism, may overcome this impairment. RCT studies in adult confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. Improving brain energy metabolism may reduce the susceptibility to migraine when brain energy demand increases due to both physiological and biopsychological factors.

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Title: Riboflavin and migraine: the bridge over troubled mitochondria
Authors: Bruno Colombo
Lorenzo Saraceno
Giancarlo Comi
Publication date: 01-05-2014
Publisher: Springer Milan
Published in: Neurological Sciences / Issue Special Issue 1/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1755-z

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