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01-02-2014 | Original Article

Influence of human myasthenia gravis thymus on the differentiation of human cord blood stem cells in SCID mice

Authors: Qian Ru Li, Ping Ping Liu, Xiao Yan Xuan, Sha Sha Guan, Ying Du, Feng Gao, Qing Yong Zhang

Published in: Neurological Sciences | Issue 2/2014

Abstract

The normal thymus contributes to T lymphocytes differentiation and induction of tolerance to self-antigens. Myasthenia gravis (MG) is characterized by abnormal thymic hyperplasia. To assess the potential influence of MG-thymus on the differentiation of T lymphocytes differentiation, we used the MG-thymus transplanted severe combined immunodeficiency (SCID) mice model to evaluate the human cord blood stem cells differentiation. Thymus fragments from MG patient and human cord blood stem cells were transplanted into SCID mice successively. SCID mice were observed to develop sustained human T lymphocytes and a functional anti-tumor immune. The levels of various T cell subsets in SCID mice with MG-thymus were different from that of control group. Among that, the frequency of CD4⁺CD25⁺ T cells was significant lower in SCID mice with MG-thymus. The deficiency of CD4⁺CD25⁺ T cells seens to contribute to the pathogenesis of MG.

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Title: Influence of human myasthenia gravis thymus on the differentiation of human cord blood stem cells in SCID mice
Authors: Qian Ru Li
Ping Ping Liu
Xiao Yan Xuan
Sha Sha Guan
Ying Du
Feng Gao
Qing Yong Zhang
Publication date: 01-02-2014
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 2/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-013-1476-8

At a glance: The STEP trials

Springer Medicine

Influence of human myasthenia gravis thymus on the differentiation of human cord blood stem cells in SCID mice

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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