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Neurological Sciences
Published in: Neurological Sciences 10/2013

01-10-2013 | Letter to the Editor

Stroke after tadalafil use

Authors: Emanuele Cannizzaro, Carla Cannizzaro, Gianluca Lopez, Daniele Lo Coco

Published in: Neurological Sciences | Issue 10/2013

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Excerpt

Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, which augments cyclic guanine monophosphate in the central nervous system, has been shown to increase neurogenesis, angiogenesis, and synaptogenesis, and to improve functional outcomes compared with placebo in a rat model of ischemic stroke [1]. …
Literature
1.
Zhang L, Zhang Z, Zhang RL, Cui Y, LaPointe MC, Silver B, Chopp M (2006) Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Res 1118:192–198PubMedCrossRef
2.
Morgan JC, Alhatou M, Oberlies J, Johnston KC (2001) Transient ischemic attack and stroke associated with sildenafil (Viagra) use. Neurology 57:1730–1731PubMedCrossRef
3.
Habek M, Petravić D (2006) Stroke—an adverse reaction to sildenafil. Clin Neuropharmacol 29:165–167PubMedCrossRef
4.
Kim KK, Kim DG, Ku YH, Lee JY, Kim WC, Kim OJ, Kim HS (2008) Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra) use. Eur J Neurol 15:306–308PubMedCrossRef
5.
Alpsan MH, Bebek N, Ciftci FD, Coban O, Bahar S, Tuncay R (2008) Intracerebral hemorrhage associated with sildenafil use: a case report. J Neurol 255:932–933PubMedCrossRef
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Carter JE (2007) Anterior ischemic optic neuropathy and stroke with use of PDE-5 inhibitors for erectile dysfunction: cause or coincidence? J Neurol Sci 262:89–97PubMedCrossRef
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Stefanović-Budimkić M, Jovanović DR, Beslać-Bumbaširević L, Ercegovac MD (2012) Recurrent ischemic stroke associated with sildenafil and tadalafil use in a young adult. Clin Neurol Neurosurg 114:405–407PubMedCrossRef
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Wright PJ (2006) Comparison of phosphodiesterase type 5 (PDE5) inhibitors. Int J Clin Pract 60:967–975PubMedCrossRef
Metadata
Title
Stroke after tadalafil use
Authors
Emanuele Cannizzaro
Carla Cannizzaro
Gianluca Lopez
Daniele Lo Coco
Publication date
01-10-2013
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 10/2013
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-013-1324-x

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