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Published in: Neurological Sciences 1/2012

01-05-2012 | FICEF SYMPOSIUM: FROM FOOD TO MIGRAINE AND BACK

Migraine and metabolism

Authors: G. Casucci, V. Villani, D. Cologno, F. D’Onofrio

Published in: Neurological Sciences | Special Issue 1/2012

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Abstract

Migraine is a chronic disorder with complex pathophysiology involving both neuronal and vascular mechanisms. Migraine is associated with an increased risk of vascular disorders, such as stroke and coronary heart disease. Obesity and diabetes are metabolic disorders with a complex association with migraine. Insulin resistance, which represents the main causal factor of diseases involved in metabolic syndrome, is more common in patients with migraine. A better understanding of the relationship between metabolic syndrome and migraine may be of great clinical interest for migraine management.
Literature
1.
go back to reference Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620PubMedCrossRef Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620PubMedCrossRef
2.
go back to reference Stang PE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, Szklo M (2005) Headache, cerebrovascular symptoms, and stroke: the atherosclerosis risk in communities study. Neurology 64:1573–1577PubMedCrossRef Stang PE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, Szklo M (2005) Headache, cerebrovascular symptoms, and stroke: the atherosclerosis risk in communities study. Neurology 64:1573–1577PubMedCrossRef
3.
go back to reference Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N (1997) Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 54:362–368PubMedCrossRef Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N (1997) Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 54:362–368PubMedCrossRef
4.
go back to reference Cook NR, Benseñor IM, Lotufo PA, Lee IM, Skerrett PJ, Chown MJ, Ajani UA, Manson JE, Buring JE (2002) Migraine and coronary heart disease in women and men. Headache 42:715–727PubMedCrossRef Cook NR, Benseñor IM, Lotufo PA, Lee IM, Skerrett PJ, Chown MJ, Ajani UA, Manson JE, Buring JE (2002) Migraine and coronary heart disease in women and men. Headache 42:715–727PubMedCrossRef
5.
go back to reference Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291PubMedCrossRef Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291PubMedCrossRef
6.
go back to reference Davey G, Sedgwick P, Maier W, Visick G, Strachan DP, Anderson HR (2002) Association between migraine and asthma: matched case–control study. Br J Gen Pract 52:723–727PubMed Davey G, Sedgwick P, Maier W, Visick G, Strachan DP, Anderson HR (2002) Association between migraine and asthma: matched case–control study. Br J Gen Pract 52:723–727PubMed
7.
go back to reference Sillanpaa M, Aro H (2000) Headache in teenagers: comorbidity and prognosis. Funct Neurol 15(suppl 3):116–121PubMed Sillanpaa M, Aro H (2000) Headache in teenagers: comorbidity and prognosis. Funct Neurol 15(suppl 3):116–121PubMed
8.
go back to reference Split W, Szydlowska M (1997) Headache in non-insulin dependent diabetes mellitus. Funct Neurol 12:327–332PubMed Split W, Szydlowska M (1997) Headache in non-insulin dependent diabetes mellitus. Funct Neurol 12:327–332PubMed
9.
go back to reference Rainero I, Limone P, Ferrero M (2005) Insulin sensitivity is impaired in patients with migraine. Cephalalgia 25:593–597PubMedCrossRef Rainero I, Limone P, Ferrero M (2005) Insulin sensitivity is impaired in patients with migraine. Cephalalgia 25:593–597PubMedCrossRef
10.
go back to reference Sattar N, Gaw A, Scherbakova O et al (2003) Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 108:414–419PubMedCrossRef Sattar N, Gaw A, Scherbakova O et al (2003) Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 108:414–419PubMedCrossRef
11.
go back to reference Resnick HE, Jones K, Ruotolo G, Jain AK, Henderson J, Lu W, Howard BV; Strong Heart Study (2003) Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic American Indians: the Strong Heart Study. Diabetes Care 26:861–867 Resnick HE, Jones K, Ruotolo G, Jain AK, Henderson J, Lu W, Howard BV; Strong Heart Study (2003) Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic American Indians: the Strong Heart Study. Diabetes Care 26:861–867
12.
go back to reference Takahashi K, Bokura H, Kobayashi S, Iijima K, Nagai A, Yamaguchi S (2007) Metabolic syndrome increases the risk of ischemic stroke in women. Intern Med 46:643–648PubMedCrossRef Takahashi K, Bokura H, Kobayashi S, Iijima K, Nagai A, Yamaguchi S (2007) Metabolic syndrome increases the risk of ischemic stroke in women. Intern Med 46:643–648PubMedCrossRef
13.
go back to reference Kurl S, Laukkanen JA, Niskanen L, Laaksonen D, Sivenius J, Nyyssönen K, Salonen JT (2006) Metabolic syndrome and the risk of stroke in middle-aged men. Stroke 37:806–811PubMedCrossRef Kurl S, Laukkanen JA, Niskanen L, Laaksonen D, Sivenius J, Nyyssönen K, Salonen JT (2006) Metabolic syndrome and the risk of stroke in middle-aged men. Stroke 37:806–811PubMedCrossRef
14.
go back to reference Iso H, Sato S, Kitamura A, Imano H, Kiyama M, Yamagishi K, Cui R, Tanigawa T, Shimamoto T (2007) Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. Stroke 38:1744–1751PubMedCrossRef Iso H, Sato S, Kitamura A, Imano H, Kiyama M, Yamagishi K, Cui R, Tanigawa T, Shimamoto T (2007) Metabolic syndrome and the risk of ischemic heart disease and stroke among Japanese men and women. Stroke 38:1744–1751PubMedCrossRef
15.
go back to reference Bigal E, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550PubMedCrossRef Bigal E, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550PubMedCrossRef
16.
go back to reference Aamodt AH, Stovner LJ, Midthjell K, Hagen K, Zwart JA (2007) Headache prevalence related to diabetes mellitus. The Head-HUNT study. Eur J Neurol 14:738–744PubMedCrossRef Aamodt AH, Stovner LJ, Midthjell K, Hagen K, Zwart JA (2007) Headache prevalence related to diabetes mellitus. The Head-HUNT study. Eur J Neurol 14:738–744PubMedCrossRef
17.
go back to reference Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291PubMedCrossRef Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291PubMedCrossRef
18.
go back to reference Schrader H, Stovner LJ, Helde G, Sand T, Bovim G (2001) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomized, placebo-controlled, crossover study. BMJ 322:19–22PubMedCrossRef Schrader H, Stovner LJ, Helde G, Sand T, Bovim G (2001) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomized, placebo-controlled, crossover study. BMJ 322:19–22PubMedCrossRef
19.
go back to reference Casucci G, Villani V, Frediani F (2008) Central mechanism of action of antimigraine prophylactic drugs. Neurol Sci 29:S123–S126PubMedCrossRef Casucci G, Villani V, Frediani F (2008) Central mechanism of action of antimigraine prophylactic drugs. Neurol Sci 29:S123–S126PubMedCrossRef
20.
go back to reference Medeiros FL, Medeiros PL, Valenca MM, Dodick D (2007) Simvastatin for migraine prevention. Headache 47:855–856PubMedCrossRef Medeiros FL, Medeiros PL, Valenca MM, Dodick D (2007) Simvastatin for migraine prevention. Headache 47:855–856PubMedCrossRef
21.
go back to reference Buzzi MG, Sakas DE, Moskowitz MA (1989) Indomethacin and acetylsalicylic acid block neurogenic plasma proteins extravasation in rat dura mater. Eur J Pharmacol 165:251–258PubMedCrossRef Buzzi MG, Sakas DE, Moskowitz MA (1989) Indomethacin and acetylsalicylic acid block neurogenic plasma proteins extravasation in rat dura mater. Eur J Pharmacol 165:251–258PubMedCrossRef
22.
go back to reference Olesen J, Thomsen LL, Iversen H (1994) Nitric oxide is a key molecule in migraine and other vascular headaches. Trends Pharmacol Sci 15:149–153PubMedCrossRef Olesen J, Thomsen LL, Iversen H (1994) Nitric oxide is a key molecule in migraine and other vascular headaches. Trends Pharmacol Sci 15:149–153PubMedCrossRef
23.
go back to reference Haffner SM (2006) Risk constellations in patients with the metabolic syndrome: epidemiology, diagnosis, and treatment patterns. Am J Med 119(Suppl 1):S3–S9PubMedCrossRef Haffner SM (2006) Risk constellations in patients with the metabolic syndrome: epidemiology, diagnosis, and treatment patterns. Am J Med 119(Suppl 1):S3–S9PubMedCrossRef
24.
go back to reference National Cholesterol Education program (NCEP) (2002) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). Third report of the National Cholesterol Education Program (NCEP) Expert panel detection, evaluation and treatment of high blood cholesterol in adults (Adult treatment panel III) final report. Circulation 106:3143–3421 National Cholesterol Education program (NCEP) (2002) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). Third report of the National Cholesterol Education Program (NCEP) Expert panel detection, evaluation and treatment of high blood cholesterol in adults (Adult treatment panel III) final report. Circulation 106:3143–3421
25.
go back to reference Guldiken B, Guldiken S, Taskiran B, Koc G, Turgut N, Kabayel L, Tugrul A (2009) Migraine and metabolic syndrome. The Neurologist 15:55–58PubMedCrossRef Guldiken B, Guldiken S, Taskiran B, Koc G, Turgut N, Kabayel L, Tugrul A (2009) Migraine and metabolic syndrome. The Neurologist 15:55–58PubMedCrossRef
26.
go back to reference Lipton RB, Bigal ME, Diamond M et al (2007) Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 68:343–349PubMedCrossRef Lipton RB, Bigal ME, Diamond M et al (2007) Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 68:343–349PubMedCrossRef
27.
go back to reference Rasmussen BK, Jensen R, Schroll M, Olesen J (1991) Epidemiology of headache in a general population—a prevalence study. J Clin Epidemiol 44:1147–1157PubMedCrossRef Rasmussen BK, Jensen R, Schroll M, Olesen J (1991) Epidemiology of headache in a general population—a prevalence study. J Clin Epidemiol 44:1147–1157PubMedCrossRef
28.
go back to reference Loevinger BL, Muller D, Alonso C, Coe CL (2007) Metabolic syndrome in women with chronic pain. Metabolism 56:87–93PubMedCrossRef Loevinger BL, Muller D, Alonso C, Coe CL (2007) Metabolic syndrome in women with chronic pain. Metabolism 56:87–93PubMedCrossRef
29.
go back to reference Bigal ME, Lipton RB (2009) The epidemiology, burden and comorbidities of migraine. Neurol Clin 27:321–334PubMedCrossRef Bigal ME, Lipton RB (2009) The epidemiology, burden and comorbidities of migraine. Neurol Clin 27:321–334PubMedCrossRef
30.
go back to reference Flegal KM, Carroll MD, Ogden CL, Curtin LR (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303:235–241PubMedCrossRef Flegal KM, Carroll MD, Ogden CL, Curtin LR (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303:235–241PubMedCrossRef
31.
go back to reference Bigal ME, Lipton RB (2006) Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology 67:252–257PubMedCrossRef Bigal ME, Lipton RB (2006) Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology 67:252–257PubMedCrossRef
32.
go back to reference Bigal ME, Tsang A, Loder E, Serrano D, Reed ML, Lipton RB (2007) Body mass index an episodic headaches: a population based study. Arch Intern Med 167:1964–1970PubMedCrossRef Bigal ME, Tsang A, Loder E, Serrano D, Reed ML, Lipton RB (2007) Body mass index an episodic headaches: a population based study. Arch Intern Med 167:1964–1970PubMedCrossRef
33.
go back to reference Horev A, Wirguin I, Lantsberg L, Ifergane G (2005) A high incidence of migraine with aura among morbidly obese women. Headache 45:936–938PubMedCrossRef Horev A, Wirguin I, Lantsberg L, Ifergane G (2005) A high incidence of migraine with aura among morbidly obese women. Headache 45:936–938PubMedCrossRef
34.
go back to reference Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia 29:269–278PubMedCrossRef Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia 29:269–278PubMedCrossRef
35.
go back to reference Bond DS, Roth J, Nash JM, Wing RR (2011) Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment. Obes Rev 12(5):e362–e371PubMedCrossRef Bond DS, Roth J, Nash JM, Wing RR (2011) Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment. Obes Rev 12(5):e362–e371PubMedCrossRef
36.
go back to reference Peterlin BL, Rapaport AM, Kurth T (2009) Migraine and obesity: epidemiology, mechanisms, and implications. Headache 50:631–648PubMedCrossRef Peterlin BL, Rapaport AM, Kurth T (2009) Migraine and obesity: epidemiology, mechanisms, and implications. Headache 50:631–648PubMedCrossRef
37.
go back to reference Peterlin BL, Rosso AL, Rapoport AM, Scher AI (2010) Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache 50:52–62PubMedCrossRef Peterlin BL, Rosso AL, Rapoport AM, Scher AI (2010) Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache 50:52–62PubMedCrossRef
38.
go back to reference Moskowitz MA (1993) Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology 43(Suppl 3):S16–S20PubMed Moskowitz MA (1993) Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology 43(Suppl 3):S16–S20PubMed
39.
go back to reference Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, Floridi A, Calabresi P (2006) Pro-inflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache 46:200–207PubMedCrossRef Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, Floridi A, Calabresi P (2006) Pro-inflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache 46:200–207PubMedCrossRef
40.
go back to reference Goadsby PJ, Edvinsson L (1993) The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 33:48–56PubMedCrossRef Goadsby PJ, Edvinsson L (1993) The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 33:48–56PubMedCrossRef
41.
go back to reference Gram DX, Hansen AJ, Wilken M, Elm T, Svendsen O, Carr RD, Ahrén B, Brand CL (2005) Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur J Endocrinol 153:963–969PubMedCrossRef Gram DX, Hansen AJ, Wilken M, Elm T, Svendsen O, Carr RD, Ahrén B, Brand CL (2005) Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur J Endocrinol 153:963–969PubMedCrossRef
42.
go back to reference Peterlin BL, Bigal ME, Tepper SJ, Urakaze M, Sheftell FD, Rapoport AM (2007) Migraine and adiponectin: is there a connection? Cephalalgia 27:435–446PubMedCrossRef Peterlin BL, Bigal ME, Tepper SJ, Urakaze M, Sheftell FD, Rapoport AM (2007) Migraine and adiponectin: is there a connection? Cephalalgia 27:435–446PubMedCrossRef
43.
go back to reference Mohammad-Ali V, Pinkney JH, Coppack SW (1998) Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 22:1145–1158CrossRef Mohammad-Ali V, Pinkney JH, Coppack SW (1998) Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord 22:1145–1158CrossRef
44.
go back to reference St-Pierre AC, Cantin B, Mauriege P et al (2005) Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ 172:1301–1305PubMedCrossRef St-Pierre AC, Cantin B, Mauriege P et al (2005) Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ 172:1301–1305PubMedCrossRef
45.
go back to reference Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356–359PubMedCrossRef Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356–359PubMedCrossRef
46.
go back to reference Aamodt AH, Stovner LJ, Midthjell K, Hagen K, Zwart JA (2007) Headache prevalence related to diabetes mellitus. The Head-HUNT study. Eur J Neurol 14:738–744PubMedCrossRef Aamodt AH, Stovner LJ, Midthjell K, Hagen K, Zwart JA (2007) Headache prevalence related to diabetes mellitus. The Head-HUNT study. Eur J Neurol 14:738–744PubMedCrossRef
47.
go back to reference Mitsias PD, Ramadan NM, Levine SR, Schultz L, Welch KM (2006) Factors determining headache at onset of acute ischemic stroke. Cephalalgia 26:150–157PubMedCrossRef Mitsias PD, Ramadan NM, Levine SR, Schultz L, Welch KM (2006) Factors determining headache at onset of acute ischemic stroke. Cephalalgia 26:150–157PubMedCrossRef
48.
go back to reference Cameron NE, Eaton SE, Cotter MA, Tesfaye S (2001) Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia 44:1973–1988PubMedCrossRef Cameron NE, Eaton SE, Cotter MA, Tesfaye S (2001) Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia 44:1973–1988PubMedCrossRef
49.
go back to reference Kihara M, Low PA (1995) Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol 32:180–185CrossRef Kihara M, Low PA (1995) Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol 32:180–185CrossRef
50.
go back to reference Split W, Szydlowska M (1997) Headache in non-insulin dependent diabetes mellitus. Funct Neurol 12:327–332PubMed Split W, Szydlowska M (1997) Headache in non-insulin dependent diabetes mellitus. Funct Neurol 12:327–332PubMed
51.
go back to reference Oral contraceptives and stroke in young women (1975) Associated risk factors. JAMA 231:718–722CrossRef Oral contraceptives and stroke in young women (1975) Associated risk factors. JAMA 231:718–722CrossRef
53.
go back to reference Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434PubMedCrossRef Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434PubMedCrossRef
54.
go back to reference Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, Diener HC, Buring JE (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64:1020–1026PubMedCrossRef Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, Diener HC, Buring JE (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64:1020–1026PubMedCrossRef
55.
go back to reference MacClellan LR, Mitchell BD, Cole JW et al (2006) Familial aggregation of ischemic stroke in young women: the Stroke Prevention in Young Women Study. Genet Epidemiol 30:602–608PubMedCrossRef MacClellan LR, Mitchell BD, Cole JW et al (2006) Familial aggregation of ischemic stroke in young women: the Stroke Prevention in Young Women Study. Genet Epidemiol 30:602–608PubMedCrossRef
56.
go back to reference Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB (2009) Migraine and cardiovascular disease: possible mechanisms of interaction. Neurology 72:1864–1871PubMedCrossRef Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB (2009) Migraine and cardiovascular disease: possible mechanisms of interaction. Neurology 72:1864–1871PubMedCrossRef
57.
go back to reference Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291PubMedCrossRef Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291PubMedCrossRef
58.
go back to reference Rose KM, Carson AP, Sanford CP et al (2004) Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology 63:2233–2239PubMedCrossRef Rose KM, Carson AP, Sanford CP et al (2004) Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology 63:2233–2239PubMedCrossRef
59.
go back to reference Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR (2007) Migraine and retinal microvascular abnormalities: the Atherosclerosis Risk in Communities Study. Neurology 68:1694–1700PubMedCrossRef Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR (2007) Migraine and retinal microvascular abnormalities: the Atherosclerosis Risk in Communities Study. Neurology 68:1694–1700PubMedCrossRef
60.
go back to reference Chrysohoou C, Pitsavos C, Skoumas J et al (2007) The emerging anti-inflammatory role of HDL-cholesterol, illustrated in cardiovascular disease free population; the ATTICA study. Int J Cardiol 122:29–33PubMedCrossRef Chrysohoou C, Pitsavos C, Skoumas J et al (2007) The emerging anti-inflammatory role of HDL-cholesterol, illustrated in cardiovascular disease free population; the ATTICA study. Int J Cardiol 122:29–33PubMedCrossRef
61.
go back to reference D’Amico D, Moschiano F, Leone M et al (1998) Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? Cephalalgia 18:618–621PubMedCrossRef D’Amico D, Moschiano F, Leone M et al (1998) Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? Cephalalgia 18:618–621PubMedCrossRef
62.
go back to reference Martinez-Sànchez P, Martìnez-Martìnez M, Fuentes B, Cuesta MV, Cuéllar-Gamboa L, Idrovo-Freire L, Fernàndez-Dominguez J, Tejedor E (2012) Migraine and hypercoagulable states in ischemic stroke. Cephalalgia 31(16):1609–1617 Martinez-Sànchez P, Martìnez-Martìnez M, Fuentes B, Cuesta MV, Cuéllar-Gamboa L, Idrovo-Freire L, Fernàndez-Dominguez J, Tejedor E (2012) Migraine and hypercoagulable states in ischemic stroke. Cephalalgia 31(16):1609–1617
63.
go back to reference D’andrea G, Bussone G, Allais G (2009) Efficacy of Ginkgolide in the prophylaxis of migraine with aura. Neurol Sci 30(suppl 1) S121–S124 D’andrea G, Bussone G, Allais G (2009) Efficacy of Ginkgolide in the prophylaxis of migraine with aura. Neurol Sci 30(suppl 1) S121–S124
64.
go back to reference Akisn M, Kultursay N, Coker I, Huseynov A (1998) Platelet activating factor is an important mediator in hypoxic ischemic brain injury in the newborn rat. Flunarizine and Ginko Biloba axtracts reduce PAF concentration in the brain. Biol Neonate 76(4):439–444 Akisn M, Kultursay N, Coker I, Huseynov A (1998) Platelet activating factor is an important mediator in hypoxic ischemic brain injury in the newborn rat. Flunarizine and Ginko Biloba axtracts reduce PAF concentration in the brain. Biol Neonate 76(4):439–444
65.
go back to reference Ramsden C, Douglas Mann J, Faurot KR et al (2011) Low omega-6 vs low omega- 6 plus high omega 3 dietary intervention for chronic daily headache: protocol for a randomized clinical trial. Trials 12:97PubMedCrossRef Ramsden C, Douglas Mann J, Faurot KR et al (2011) Low omega-6 vs low omega- 6 plus high omega 3 dietary intervention for chronic daily headache: protocol for a randomized clinical trial. Trials 12:97PubMedCrossRef
Metadata
Title
Migraine and metabolism
Authors
G. Casucci
V. Villani
D. Cologno
F. D’Onofrio
Publication date
01-05-2012
Publisher
Springer Milan
Published in
Neurological Sciences / Issue Special Issue 1/2012
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-012-1047-4

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