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01-04-2012 | Case Report

Brain tuberculoma (Mycobacterium africanum): high index of suspicion helps in avoiding biopsy/surgery

Authors: A. Botturi, E. Prodi, A. Silvani, P. Gaviani, G. Vanoli, A. Carbone, A. Salmaggi

Published in: Neurological Sciences | Issue 2/2012

Abstract

Partial seizures can be due to a growing cerebral lesion, which may be tumoral or inflammatory/infectious in nature. The differential diagnosis is obviously important; increasing immigration to Europe from Africa is leading to an increase of infectious disease involving also the central nervous system. The authors report imaging the a case of a brain tuberculoma due to Mycobacterium africanum mimicking brain tumor, in which diagnosis was possible by inoculum in guinea-pig of material obtained by mediastinal biopsy of enlarged lymph nodes. Specific treatment led to marked reduction in the size of the brain lesion.

Bernaerts A, Vanhoenacker FM, Parizel PM, Van Goethem JW, Van Altena R, Laridon A, De Roeck J, Coeman V, De Schepper AM (2003) Tuberculosis of the central nervous system: overview of neuroradiological findings. Eur Radiol 13(8):1876–1890 ReviewPubMedCrossRef

Cataño JC (2007) Images in clinical medicine. Cerebral tuberculoma. N Engl J Med 57(21):2166CrossRef

Giese A, Kucinski T, Hagel C, Lohmann F (2003) Intracranial tuberculomas mimicking a malignant disease in an immunocompetent patient. Acta Neurochir (Wien) 145(6):513–517 discussion 517

Qin L, Zheng R, Fan C, Cai J, Liu Z, Wang J, Lu J, Jin R, Yang H, Cui Z, Feng Y, Hu Z (2010) Identification and evaluation of a new nucleic acid amplification test target for specific detection of Mycobacterium tuberculosis. Clin Chem Lab Med 48(10):1501–1505PubMedCrossRef

Cheng VCC, Yew WW, Yuen KY (2005) Molecular diagnostics in tuberculosis. Eur J Clin Microbiol Infect Dis 24:711–720PubMedCrossRef

Laraque F, Griggs A, Slopen M, Munsiff SS (2009) Performance of nucleic acid amplification tests for diagnosis of tuberculosis in a large urban setting. Clin Infect Dis 49(1):46–54PubMedCrossRef

Poonnoose SI, Singh S, Rajshekhar V (2004) Giant cerebellar tuberculoma mimicking a malignant tumour. Neuroradiology 46(2):136–139PubMedCrossRef

Del Brutto OH, Mosquera A (1999) Brainstem tuberculoma mimicking glioma: the role of antituberculous drugs as a diagnostic tool. Neurology 52(1):210–211PubMed

Title: Brain tuberculoma (Mycobacterium africanum): high index of suspicion helps in avoiding biopsy/surgery
Authors: A. Botturi
E. Prodi
A. Silvani
P. Gaviani
G. Vanoli
A. Carbone
A. Salmaggi
Publication date: 01-04-2012
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 2/2012
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-011-0742-x

At a glance: The STEP trials

Springer Medicine

Brain tuberculoma (Mycobacterium africanum): high index of suspicion helps in avoiding biopsy/surgery

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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