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Neurogenetics
Published in: neurogenetics 1/2013

Open Access 01-02-2013 | Short Communication

Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y

Authors: Mohammed Yusuf, Kay Leung, Keith J. Morris, Emanuela V. Volpi

Published in: Neurogenetics | Issue 1/2013

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Abstract

The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neuronal phenotype. This property has conferred them the potential to be used as an in vitro model for studies of neurodegenerative and neurodevelopmental disorders. Here, we present a comprehensive assessment of the SH-SY5Y cytogenomic profile. Our results advocate for molecular cytogenetic data to inform the use of cancer cell lines in research.
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Metadata
Title
Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
Authors
Mohammed Yusuf
Kay Leung
Keith J. Morris
Emanuela V. Volpi
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Neurogenetics / Issue 1/2013
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI
https://doi.org/10.1007/s10048-012-0350-9

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